Researchers from the laboratory of Leng-Siew Yeap at the Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine and Fei-Long Meng at the Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences have reported the results of their groundbreaking study to elucidate the mechanisms that promote somatic hypermutation at the antigen-binding sites of ...

The list of winners of the 2022 Shanghai Medical Science and Technology Award has been released.

Recently, Professor Yingyan Yu's team from Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine published a review article entitled "Patient-derived organoids in translational oncology and drug screening" in Cancer Letters, an authoritative international journal on cancer research. This paper comprehensively describes the latest progress in patient-derived organoid (PD...

On March 28th,2023,the team of Academician Xianqun Fan from the Department of Ophthalmology atShanghaiNinth People's Hospital, Shanghai Jiao Tong University School of Medicine published a research article titled "Nuclear PD-L1 promotes EGR1-mediated angiogenesis and accelerates tumorigenesis" in Cell Discovery. The study reveals a higher proportion of nuclear programmed cell death ligand 1 (PD...

The article DNA Repair Mechanisms That Promote Insertion-Deletion Events During Immunoglobulin Gene Diversificationwas published in Science Immunology by PI Leng-Siew Yeap Lab of Shanghai Jiao Tong University School of Medicine/Shanghai Institute of Immunology on March 24, 2023, reported the results of their work to elucidate the mechanisms that generate rare mutagenic outcomes of antibody dive...

The article STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretionwas published inImmunityby Professor Junling Liu / Yanyan Xu Lab of Shanghai Jiao Tong University School of Medicine on March 20, 2023, systematically revealed the deep mechanism of how platelets respond to bacterial and other microbial infection stimulation and the relea...