Congenital heart disease (CHD) ranks as the highest disease burden among birth defects, whether in Western developed countries or in China. Reducing CHD deaths is of great significance to achieving the United Nations' Sustainable Development Goals (SDGs). China is one of the countries holding the largest number of patients with CHDs and the heaviest disease burden in the world. Since the reform...

The team led by Xia Qiang from Renji Hospital, Shanghai Jiao Tong University School of Medicine and the team led by Zuo Xiaolei publish a new strategy forinterdisciplinary fusion of transplant immunology, synthetic biology, and material science

The function and homeostasis of bone relies on the balanced bone remodeling process, which is a continuously cycle of bone formation mediated by osteoblasts and resorption mediated by osteoclasts throughout life. Osteoclasts are hematopoietic myeloid lineage and derived from bone marrow-derived monocytes (BMDMs). The defective osteoclast differentiation willdisturb the skeletal architecture and...

On May 2rd, 2023, the Journal of the American Medical Association (JAMA), one of the world's top academic journals with an impact factor of 157.335, published the results of a multicenter, randomized, double-blind, placebo-controlled clinical study entitled "Prednisone vs Placebo and Live Birth in Patients With Recurrent Implantation Failure Undergoing In Vitro Fertilization", jointly conducte...

Researchers from the laboratory of Leng-Siew Yeap at the Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine and Fei-Long Meng at the Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences have reported the results of their groundbreaking study to elucidate the mechanisms that promote somatic hypermutation at the antigen-binding sites of ...

The list of winners of the 2022 Shanghai Medical Science and Technology Award has been released.