Biography

• I graduated in 1983 from Xin Jiang Medical University and got a Bachelor’s degree in Medicine. I passed into Shanghai Second Medical University as a Master student in 1986 and then PhD student in 1988, majoring in Endocrinology & Metabolism Diseases, and received a PhD degree in 1991. After 1995, I did my research work on leukemogenesis in Memorial Sloan-Kettering Cancer Center in New York, and moved back to Shanghai Jiao Tong University School of Medicine in 1991. Hereafter, my major research work focus on the technology platform for developing genetically modified mouse models, functional genomics analysis of unknown function genes, and the pathogenesis of human genetic diseases. In the past two decades, my group have developed a professional R&D platform for model organism research, providing crucial technical support in a large scale in China. We have analyzed a wide range of mouse models with modified unknown function genes, such as palladin, Plag1, Rig-I, Kif18a, Adiponectin, Opg, Gpr110, Prss37, Prss54, Prss55, Adgra1, etc. Through comprehensive phenotyping analysis, we have uncovered the crucial roles of above-mentioned genes in embryogenesis, erythrogenesis, tumorigenesis, spermatogenesis, male infertility and so on. We have also identified two novel disease-causing genes FGF9 and DHTKD1 for multiple synostoses syndrome and Charcot-Marie-Tooth disease in Chinese pedigrees, respectively.

Representative Publications

1. Huijun Luo, Xuesong Liu, Fang Wang, Qiuhua Huang, Shuhong Shen, Long Wang, Guojiang Xu, Xia Sun, Hui Kong, Mingmin Gu, Saijuan Chen, Zhu Chen, Zhugang Wang. Disruption of palladin results in neural tube closure defects in mice. Mol Cell Neurosci. 2005 Aug; 29(4): 507-15.

2. Xudong Zhao, Weihua Ren, Wenjun Yang, Yi Wang, Hui Kong, Long Wang, Lanzhen Yan, Guojiang Xu, Jian Fei, Jiliang Fu, Chenping Zhang, Zhugang Wang. Wnt Pathway Is Involved in Pleomorphic Adenomas Induced by Overexpression of PLAG1 in Transgenic Mice. International Journal of Cancer 2006; 118(3): 643-648.

3. Xue-Song Liu, Xi-Hua Li, Yi Wang, Run-Zhe Shu, Long Wang, Shun-Yuan Lu, Hui Kong, Yue-E Jin, Li-Jun Zhang, Jian Fei, Sai-Juan Chen, Zhu Chen, Ming-Min Gu, Zhen-Yu Lu, Zhu-Gang Wang. Disruption of palladin leads to defects in definitive erythropoiesis by interfering with erythroblastic island formation in mouse fetal liver. Blood. 2007 Aug 1; 110(3): 870-6.

4. Xiao-lin Wu, Ming-min Gu, Lei Huang, Xue-song Liu, Hong-xin Zhang, Xiao-yi Ding, Jian-qiang Xu, Bin Cui, Long Wang, Shun-yuan Lu, Xiao-yi Chen, Hai-guo Zhang, Wei Huang, Wen-tao Yuan, Jiang-ming Yang, Qun Gu, Jian Fei, Zhu Chen, Zhi-min Yuan, Zhu-Gang Wang. Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene. Am J Hum Genet. 2009 Jul; 85(1): 53-63.

5. Xue-song Liu, Xu-dong Zhao, Xiao-xing Wang, Yi-xin Yao, Liang-liang Zhang, Run-zhe Shu, Wei-hua Ren, Ying Huang, Lei Huang, Ming-min Gu, Ying Kuang, Long Wang, Shun-yuan Lu, Jun Chi, Jing-sheng Fen, Yi-fei Wang, Jian Fei, Wei Dai, Zhu-gang Wang. Germinal cell aplasia in Kif18a mutant male mice due to impaired chromosome congression and dysregulated BubR1 and CENP-E. Genes Cancer. 2010 Jan; 1(1): 26-39.

6. Xu WY, Gu MM, Sun LH, Guo WT, Zhu HB, Ma JF, Yuan WT, Kuang Y, Ji BJ, Wu XL, Chen Y, Zhang HX, Sun FT, Huang W, Huang L, Chen SD, Wang ZG. A nonsense mutation in DHTKD1 causes Charcot-Marie-Tooth disease type 2 in a large Chinese pedigree. Am J Hum Genet. 2012 Dec 7; 91(6): 1088-94.

7. Zhang HX, Liu ZX, Sun YP, Zhu J, Lu SY, Liu XS, Huang QH, Xie YY, Zhu HB, Dang SY, Chen HF, Zheng GY, Li YX, Kuang Y, Fei J, Chen SJ, Chen Z, Wang ZG. Rig-I regulates NF-κB activity through binding to Nf-κb1 3'-UTR mRNA. Proc Natl Acad Sci USA 2013 Apr 16; 110(16): 6459-64.

8. Shen CL, Kuang Y, Liu JB, Feng JS, Chen XY, Wu WT, Chi J, Tang LY, Wang YH, Fei J, Wang ZG. Prss37 is required for male fertility in the mouse. Biol Reprod. 2013 May 16; 88(5): 123.

9. Ma BT, Zhu J, Tan J, Mao YL, Tang LY, Shen CL, Zhang HX, Kuang Y, Fei J, Yang X, Wang ZG. Gpr110 deficiency decelerates carcinogen-induced hepatocarcinogenesis via activation of the IL-6/STAT3 pathway. Am J Cancer Res. 2017 Mar 1; 7(3): 433-447.

10. Shang X, Shen C, Liu J, Tang L, Zhang H, Wang Y, Wu W, Chi J, Zhuang H, Fei J, Wang Z. Serine protease PRSS55 is crucial for male mouse fertility via affecting sperm migration and sperm-egg binding. Cell Mol Life Sci. 2018 Dec; 75(23): 4371-4384.

11. 11.Shen C, Xiong W, Li C, Ge H, Shen Y, Tang L, Zhang H, Lu S, Fei J, Wang Z. Testis-specific serine protease PRSS54 regulates acrosomal granule localization and sperm head morphogenesis in mice. Biol Reprod. 2022 Jul 21:ioac146.

12. Lingyun Tang, Min Wu, Shunyuan Lu, Hongxin Zhang, Yan Shen, Chunling Shen, Hui Liang, Haoyang Ge, Xiaoyi Ding, Zhugang Wang. Fgf9 Negatively Regulates Bone Mass by Inhibiting Osteogenesis and Promoting Osteoclastogenesis via MAPK and PI3K/AKT signaling. J Bone Miner Res. 2021 Apr; 36(4): 779-791.