Biography

• Rui-yan Zhang is professor of medicine, chief physician, doctoral supervisor, and director of the Department of Cardiovascular Medicine and the director of the Cardiac Catheterization Lab, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine. He has been awarded Shanghai Leading Talent. He is a member of the Standing Committee of the Cardiovascular Disease Branch of the Chinese Medical Association, the deputy head of the Coronary Heart Disease and Atherosclerosis Group, and a standing member of the Cardiovascular Medicine Branch of the Chinese Medical Doctor Association. He is the vice chair of the Shanghai Medical Association Cardiovascular Society, and the valve working group.

• He specializes in interventional therapy of coronary heart disease and peripheral artery disease. He focuses on translational research in areas of coronary heart disease and acute myocardial infarction. He receives a number of research fundings from the 863 Project, the Ministry of Science and Technology, and the National Natural Science Foundation of China. He has published more than 100 academic articles in journals such as Circulation, J Am Coll Cardiol, Circulation Research, Eur Heart J, and Circ Res. He has been awarded the second prize of the National Science and Technology Progress Award, the Ministry of Education Science and Technology Progress Award, and Shanghai Science and Technology Progress Award.

Publications

1. Huang CK, Dai D, Xie H, Zhu Z, Hu J, Su M, Liu M, Lu L, Shen W, Ning G et al: Lgr4 Governs a Pro-Inflammatory Program in Macrophages to Antagonize Post-Infarction Cardiac Repair. Circ Res 2020, 127(8):953-973.

2. Zhu Z, Wu Y, Shen Z, Xu Y, Li Y, Wang Y, Su X, Li B, Jiang T, Jiang J et al: Safety and efficacy of zotarolimus-eluting stents in the treatment of diabetic coronary lesions in Chinese patients: The RESOLUTE-DIABETES CHINA Study. Journal of diabetes 2019, 11(3):204-213.

3. Dai Y, Shen Y, Li QR, Ding FH, Wang XQ, Liu HJ, Yan XX, Wang LJ, Yang K, Wang HB et al: Glycated Apolipoprotein A-IV Induces Atherogenesis in Patients With CAD in Type 2 Diabetes. J Am Coll Cardiol 2017, 70(16):2006-2019.

4. Ying Y, Yang K, Liu Y, Chen QJ, Shen WF, Lu L, Zhang RY: A uremic solute, P-cresol, inhibits the proliferation of endothelial progenitor cells via the p38 pathway. Circ J 2011, 75(9):2252-2259.

5. Zhuang L, Jia K, Chen C, Li Z, Zhao J, Hu J, Zhang H, Fan Q, Huang C, Xie H et al: DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics. Circulation 2022, 145(11):829-846.

6. Yang CD, Shen Y, Ding FH, Yang ZK, Hu J, Shen WF, Zhang RY, Lu L, Wang XQ: Visit-to-visit fasting plasma glucose variability is associated with left ventricular adverse remodeling in diabetic patients with STEMI. Cardiovasc Diabetol 2020, 19(1):131.

7. Yu X, Lu J, Li J, Guan W, Deng S, Deng Q, Ye H, Han W, Yu Y, Zhang R: Serum Triglyceride Lipase Concentrations are Independent Risk Factors for Coronary Artery Disease and In-Stent Restenosis. J Atheroscler Thromb 2019, 26(9):762-774.

8. Liu L, Ding F, Gutiérrez-Chico JL, Zhu J, Zhu Z, Du R, Yang Z, Hu J, Tu S, Zhang R: Prognostic value of post-procedural μQFR for drug-coated balloons in the treatment of in-stent restenosis. Cardiol J 2021.

9. Song B, Dai D, Liu S, Zhu Z, Ding F, Zhu J, Zhang R: Optimal timing of coronary angiograms for patients with chronic kidney disease: association between the duration of kidney dysfunction and SYNTAX scores. Ren Fail 2021, 43(1):307-312.

10. Han H, Dai D, Du R, Hu J, Zhu Z, Lu L, Zhu J, Zhang R: Oncostatin M promotes infarct repair and improves cardiac function after myocardial infarction. Am J Transl Res 2021, 13(10):11329-11340.

11. Ni J, Yang W, Shen W, Zhang R: Haem oxygenase-1 inhibits neointimal hyperplasia in rat by histone deacetylase 2. Free Radic Res 2018, 52(10):1110-1117.

12. Lu L, Zhang RY, Wang XQ, Liu ZH, Shen Y, Ding FH, Meng H, Wang LJ, Yan XX, Yang K et al: C1q/TNF-related protein-1: an adipokine marking and promoting atherosclerosis. Eur Heart J 2016, 37(22):1762-1771.

13. Tian L, Wang Y, Zhang R: Galectin-3 induces vascular smooth muscle cells calcification via AMPK/TXNIP pathway. Aging (Albany NY) 2022, 14(12):5086-5096.

14. Sun JT, Liu Y, Lu L, Liu HJ, Shen WF, Yang K, Zhang RY: Diabetes-Invoked High-Density Lipoprotein and Its Association With Coronary Artery Disease in Patients With Type 2 Diabetes Mellitus. Am J Cardiol 2016, 118(11):1674-1679.

15. Sun JT, Yang K, Mao JY, Shen WF, Lu L, Wu QH, Wang YP, Wu LP, Zhang RY: Cyanate-Impaired Angiogenesis: Association With Poor Coronary Collateral Growth in Patients With Stable Angina and Chronic Total Occlusion. J Am Heart Assoc 2016, 5(12).