Biography

• Limei Liu, Professor, Doctoral supervisor, Senior scientist, Shanghai leading talent; Shanghai outstanding academic leader. Chairman of Medical Genetics Expert Specialty Committee of Shanghai Medical Association; First Vice Director of Shanghai Diabetes Institute; Professor of Shanghai Jiao Tong University School of Medicine. Focus on endocrine metabolic disease, expert in the hereditary special types of diabetes mellitus: maturity-onset diabetes of the young (MODY), mitochondria diabetes, neonatal diabetes, gestational diabetes mellitus (GDM), type 2 diabetes(T2D) and complications, obesity，hypertension, etc., to investigate the genetic mechanisms, genetic counseling, precision diagnosis and targeting therapy. Editorial Boards of J Diab Inv, Mol Cell Biochem and J Bio-X Res, etc. Taking charge of a number of National Natural Science Foundation of China, Shanghai Science and Technology Commission Foundation, Shanghai Natural Science Foundation, etc. Because of she discovered the Chinese MODY2 and MODY13 pathogenic genes and prevalence, were awarded the “Top 10 Women Scientists with Outstanding Contribution in Life Science Field in 2018” and “China Diabetes Top 10 Most Influential Research Award in 2013”, respectively. She has made outstanding contributions to the precision diagnosis and treatment of MODY in Chinese. She was awarded the second prize of National Science and Technology Progress and the third prize of Shanghai Science and Technology Progress. She has published more than 100 SCI articles on Diabetes Care, Diabetologia, Hypertension, Int J Obes, Metabolism, Clin Sci, Mol Cell Biochem, etc.

Representative publications

1. Jiang Y, Jiang F, Li M, Wu Q, Xu C, Zhang R, Song M, Wang Y, Wang Y, Chen Y, Zhang J, Ge X, Zhu Q, Zhuang L, Yang D, Lu M, Wang F, Jiang M, Liu X, Liu Y, Liu L*. Identification and management of GCK-MODY complicating pregnancy in Chinese patients with gestational diabetes. Mol Cell Biochem. 2022 May;477(5):1629-1643.(*通讯作者）

2. Wang Y, Wang J, Yang R, Wang P, Porche R, Kim S, Lutfy K, Liu L*, Friedman TC, Jiang M, Liu Y. Decreased 11β-Hydroxysteroid Dehydrogenase Type 2 Expression in the Kidney May Contribute to Nicotine/Smoking-Induced Blood Pressure Elevation in Mice. Hypertension. 2021 Jun;77(6):1940-1952.(*通讯作者）

3. Zhang J, Liu Y, Li M, Ge X, Wang Y, Huang X, Yang D, Zhang R, Chen Y, Lu M, Yin J, Song M, Wang Y, Wang Y, Wang F, Jiang M, Liu L*. Identification of Ala2Thr mutation in insulin gene from a Chinese MODY10 family. Mol Cell Biochem. 2020 Jul;470(1-2):77-86. (*通讯作者）

4. Liu L*, Wang Y, Wang J, Dong Y, Chang S, Liu X, Lutfy K, Chen H, Friedman TC, Jiang M, Liu Y. Enhanced hexose-6-phosphate dehydrogenase expression in adipose tissue may contribute to diet-induced visceral adiposity. Int J Obes (Lond). 2018 Dec;42(12):1999-2011.（*第一作者）

5. Limei Liu*, Yanjun Liu, Xiaoxu Ge, Xipeng Liu, Chen Chen, Yanzhong Wang, Juan Zhang, Yating Chen, Rong Zhang, Weijing Zhao, Yanyan Jiang, Di Yang, Taishan Zheng, Meisheng Jiang. Insights into pathogenesis of five novel GCK mutations identified in Chinese MODY patients. Metabolism. 2018. 89: 8–17  （*第一兼通讯作者）

6. Wang Y, Yan C, Liu L*, Wang W, Du H, Fan W, Lutfy K, Jiang M, Friedman TC, Liu Y. 11β-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominaladipose tissue. Am J Physiol Endocrinol Metab. 2015.308(1):E84-95（第一作者）

7. Limei Liu*, Kazuaki Nagashima, Takao Yasuda, Yanjun Liu, Hai-rong Hu, Guang He, Bo Feng, Mingming Zhao, Langen Zhuang, Taishan Zheng, Theodore C. Friedman, Kunsan Xiang. Mutations in KCNJ11 are associated with the development of autosomal dominant, early-onset type 2 diabetes. Diabetologia. 2013. 56(12):2609-18 （*第一兼通讯作者）

8. Limei Liu*, Taishan Zheng, Feng Wang, Niansong Wang, Yanyan Song, Ming Li, Lifang Li, Jiamei Jiang, Weijing Zhao. Pro12Ala polymorphism in the PPARG gene contributes to the development of diabetic nephropathy in Chinese type 2 diabetes. Diabetes Care. 2010.33:144–149.（*第一兼通讯作者）

9. Limei Liu*, Taishan Zheng, Niansong Wang, Feng Wang, Ming Li, Jiamei Jiang, Ruie Zhao, Lifang Li, Weijing Zhao, Qihan Zhu, Weiping Jia. The manganese superoxide dismutase Val16Ala polymorphism is associated with decreased risk of diabetic nephropathy in Chinese patients with type diabetes. Mol Cell Biochem. 2009. 22:87-91（*第一兼通讯作者）

10. Liu L*, Furuta H, Minami A, Zheng T, Jia W, Nanjo K, Xiang K. A novel mutation, Ser159Pro in the NeuroD1/BETA2 gene contributes to the development of diabetes in a Chinese potential MODY family. Mol Cell Biochem. 2007 Sep;303(1-2):115-20. （*第一兼通讯作者）