Biography

• Dr. Kang Sun is a Professor in the Center for Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine. He serves as an associate editor for American Journal of Reproductive Immunology, Frontiers in Endocrinology and Frontiers in Physiology, as well as a council member of Chinese Society of Reproductive Biology. His research covers: the initiating mechanism underlying sterile inflammation in human gestational tissues in normal parturition and preterm birth; the role of placental gene expression in the regulation of fetal growth; the crosstalk between endocrine hormones and immune system in pregnancy; and the pathogenesis of polycystic ovary syndrome. Dr. Sun has published over 130 peer-reviewed articles and book chapters including publications in Endocrine Reviews, BMC Medicine, Diabetes, Science Signaling, Clinical & Translational Medicine, Cell & Bioscience, Human Reproduction, Journal of Clinical Endocrinology & Metabolism, Endocrinology, Journal of Lipid Research and Journal of Immunology. He is the chief editor of the Chinese book “Basic and Clinical Placenta Endocrinology.”  The research team led by Dr. Sun has made a number of original findings in the study of the triggering mechanisms of human parturition, including the feedforward cortisol regenerating system and the feedforward loop between prostaglandins and 15-HETE in human fetal membranes. He is the recipient of National Science and Technology Award of China, Shanghai Medical Science and Technology Award and Army Science and Technology Award.

Publications

1. Fan Zhang, Kang Sun*, Wang-Sheng Wang*. Identification of a feed-forward loop between 15(S)-HETE and PGE2 in human amnion at parturition. Journal of Lipid Research 2022, DOI:10.1016/j.jlr.2022.100294.

2. Jiang-Wen Lu, Wen-Jia Lei, Li-Jun Ling, Lu-Yao Wang, Yi-Kai Lin, Fan Zhang， Meng-Die Li, Fan Pan, Wang-Sheng Wang, Kang Sun*. Cortisol stimulates local progesterone withdrawal through induction of AKR1C1 in human amnion fibroblasts at parturition. Endocrinology 2022,163(11):bqac148. doi: 10.1210/endocr/bqac148.

3. Ya-nan Zhu, Xiao-wen Gan, Fan Pan, Xiao-tian Ni，Leslie Myatt, Wang-sheng Wang*, Kang Sun*. Role of EZH2-mediated H3K27me3 in placental ADAM12-S expression: implications for fetoplacental growth. BMC Medicine 2022，20：189. https://doi.org/10.1186/s12916-022-02391-4.

4. Wang-sheng Wang*, Yi-kai Lin, Fan Zhang, Wen-jia Lei, Fang Pan, Ya-nan Zhu, Jiang-wen Lu, Chu-yue Zhang, Qiong Zhou, Hao Ying, Kang Sun*. Single cell transcriptomic analysis of human amnion identifies cell-specific signatures associated with parturition. Cell and Bioscience 2022; 12:64. https://doi.org/10.1186/s13578-022-00797-4.

5. Jiang-wen Lu, Wang-sheng Wang*, Qiong Zhou, Li-jun Ling, Hao Ying, Yun Sun, Leslie Myatt, Kang Sun*. C/EBPδ drives key endocrine signals in human fetal membranes at parturition. Clinical and Translational Medicine 2021;11:e416. doi: 10.1002/ctm2.416.

6. Wang WS, Chen ZJ, Myatt L, Sun K*. 11β-HSD1 in human fetal membranes as a potential therapeutic target for preterm birth. Endocrine Reviews 2018, 39:241-260. DOI: 10.1210/er.2017-00188.