Biography

• He got the doctor degree from Shanghai Second Medical University on 1996. He worked NIH/NCI, University of Michigan and University of Connecticut, USA as a post-doctoral fellow or a visiting scholar from 1998 to 2001 and 2004. Now, he is the vice president of Renji Hospital, director of gastroenterology division and director of Shanghai Institute of Digestive Disease, School of Med, Shanghai Jiaotong Univ. His current research interests focus on the gut microbe, the epigenetic modifications, cell signaling pathways during the pathogenesis and prevention of GI cancers. He has published more than 170 papers in English as corresponding author.

Publications

1. Yu T*, Guo F*, Yu Y, Sun T, Ma D, Han J, Qian Y, Kryczek I, Sun D, Nagarsheth N, Chen Y#, Chen H#, Hong J#, Zou W#, Fang JY#. F. nucleatum affects chemoresistance via targeting selective microRNA and autophagy in colorectal cancer patients. Cell, 2017;170(3):548-63

2. Fang JY#, Richardson BC. The MAPK signaling pathway and human colorectal cancer. Lancet Oncol, 2005;6(5):322-7

3. Chen YX*, Gao QY*, Zou TH*, Wang BM*, Liu SD*, Sheng JQ*, Ren JL*, Zou XP*, Liu ZJ*, Song YY, Xiao B, Sun XM, Dou XT, Cao HL, Yang XN, Li N, Kang Q, Zhu W, Xu HZ, Chen HM, Cao XC, Fang JY#. Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study. Lancet Gastroenterology & Hepatology, 2020；5(3)：267-75

4. Sun TT*, He J*, Liang Q, Ren LL, Yan TT, Yu TC, Tang JY, Bao YJ, Hu Y, Lin YW, Sun D, Chen YX, Hong J#, Chen HY#, Zou W#, Fang JY#. LncRNA GClnc1 promotes gastric carcinogenesis and may act as a modular scaffold of WDR5 and KAT2A complexes to specify the histone modification pattern. Cancer Discovery, 2016; 6(7):784-801

5. Su WY, Li JT, Cui Y, Hong J, Du W, Wang YC, Lin YW, Xiong H, Wang JL,  Kong X,  Gao QY, Wei LP, Fang JY#. Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer. Cell Res, 2012; 22(9):1374-89

6. Yan T*, Shen C*, Jiang P*, Yu C, Guo F, Tian X, Zhu X, Lu S, Han B, Zhong M, Chen J, Liu Q, Chen Y, Zhang J#, Hong J#, Chen H#, Fang JY# . Risk SNP-induced lncRNA-SLCC1 drives colorectal cancer through activating glycolysis signaling. Signal Transduction and Targeted Therapy, 2021;6(1):70.

7. Zhou CB*, Pan SY*, Jin P*, Xue JH, Xie YH, Deng JW, Cao H, Liu Q, Xie WF, Zou X, Sheng JQ, Wang BM, Wang H, Ren JL, Liu SD, Sun YW, Meng XJ, Zhao G, Chen JX, Cui Y, Wang PQ, Guo HM, Yang L, Chen X, Ding J, Yang XN, Wang XK, Qian AH, Hou LD, Wang Z#, Chen YX#, Fang JY#. Fecal markers Streptococcus anginosus and Streptococcus constellatus for non-invasive screening and early warning of gastric cancer Short title： Fecal markers for gastric cancer screening. Gastroenterology, 2022; 162(7):1933-47

8. Qian J, Kong X, Deng N, Tan P, Chen H, Wang J, Li Z, Hu Y, Zou W, Xu J #, Fang JY#. OCT1 is a determinant of synbindin-related ERK signaling with independent prognostic significance in gastric cancer. Gut, 2015;64(1): 37-48

9. Hong J*, Guo F*, Lu S*, Shen C, Ma D, Zhang X, Yu T, Sun T, Yan T, Qian Y, Xie Y, Zhong M, Chen J, Peng Y, Wang C, Zhou X, Liu J, Liu Q, Ma X, Chen Y, Chen H#, Fang JY#. F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer. Gut, 2021; 70(11)：2123-37