Biography

• Dr. Dong is Professor at Shanghai Jiaotong University School of Medicine and Director for the Shanghai Immune Therapy Institute, as well as a principal investigator at the Institute for Immunology at Tsinghua University. Dr. Dong served as the Dean of Tsinghua University School of Medicine in 2016-2020. Dr. Dong’s research is to understand the molecular mechanisms whereby immune and inflammatory responses are normally regulated, and to apply this knowledge to the understanding and treatment of infection, autoimmunity and allergy disorders as well as cancer. The work from Dr. Dong’s group has led to the discoveries of Th17 and T follicular helper (Tfh) cell subsets in the immune system and elucidation of their biological and pathological functions. Dr. Dong has over 200 publications and was rated highly cited researcher for seven times. The honors he has received include the 2009 American Association of Immunologists-BD Bioscience Investigator Award and 2019 International Cytokine and Interferon Society Biolegend-William E. Paul Award. He is a member of the Chinese Academy of Sciences and a fellow of the American Association for the advancement of Science and the Chinese Academy of Medicine. He is currently Editor-in-chief for Frontiers in Immunology- T Cell Biology, Associate Editor for Current Opinion in Immunology, Advances in Immunology and China Sciences- Life Sciences, and an Editor for Annual Review of Immunology and Immunity, and a Scientific Advisor for Med.

Publications

1. Zhang, Y., Blattman, J., Kennedy, N., Duong, J., Nguyen, T.,Wang, Y., Davis, R. J., Greenberg, P., Flavell, R. A. and Dong, C. Regulation of innate and adaptive immune responses by MAP kinase phosphatase.(2004) Nature 430：793-797

2. Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R. I.,Wang, Y., Hood, L., Tian, Q. and Dong, C. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 (2005) Nature Immunology 6：1133-1141

3. Nurieva, R., Yang, X. O., Martinez, G., Zhang, Y., Panopoulos,A. D., Ma, L., Schluns, K., Tian, Q., Watowich, S. S., Jetten, A. M. and Dong, C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells (2007) Nature 448：480-483

4. Yang, X. O., Nurieva, R., Martinez, G. J., Chung, Y., Kang, H. S., Pappu, B. P., Shah, B., Chang, S. H., Schluns, K. S., Watowich, S. S., Feng, X., Jetten, A. M. and Dong, C. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. (2008) Immunity. 29:44-56.

5. Nurieva, R. I., Chung, Y., Hwang, D., Yang, X. O., Kang, H. S., Ma, L., Wang, Y.-H., Watowich, S. S., Jetten, A. M., Tian, Q. and Dong, C. Generation of follicular helper T cells is mediated by IL-21 but independent of TH1, TH2 or TH17 lineages. (2008) Immunity 29：138-149

6. Nurieva, R. I., Chung, Y., Martinez, G. J., Yang, X. O., Tanaka,S., Matskevitch, T. D., Wang, Y.-H. and Dong, C. Bcl6 mediates the development of T follicular helper cells (2009) Science 325：1001-1005.

7. Chung, Y., Chang, S. H., Martinez, G. J., Yang, X. O., Nurieva, R., Kang, H. S., Ma, L., Watowich, S. S., Jetten, A., Tian, Q. and Dong, C. Critical regulation of early Th17 cell differentiation by IL-1 signaling.(2009) Immunity 30：576-587

8. Angkasekwinai, P., Chang, S. H., Thapa, M., Watarai, H. and Dong, C. Regulation of IL-9 expression by IL-25 signaling (2010) Nature Immunology 11：250-256

9. Nurieva, R. I., Zheng, S., Jin, W., Chung, Y., Martinez, G. J., Zhang, Y., Reynolds, J. M., Wang, S.-L., Lin, X., Sun, S.-C., Lozano, G. and Dong, C.

10. The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation (2010) Immunity 32：670-680

11. Chung, Y., Tanaka, S., Chu, F., Nurieva, R., Martinez, G. J.,Rawal, S., Wang, Y.-H., Lim, H. Y., Reynolds, J. M., Zhou, X.-H., Fan,H.-M., Liu, Z.-M., Neelapu, S. S. and Dong, C. Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions (2011) Nature Medicine 17：983-988

12. Chang, S. H., Reynolds, J. M., Pappu, B. P., Chen, G., Martinez, G. J. and Dong, C. Regulation of TH17 cell responses and autoimmune disease by IL-17C/IL-17RE. (2011) Immunity 29：611-621

13. Liu, X., Chen, X., Zhong, B., Wang, A., Wang, X., Chu, F., Nurieva, R. I., Yan, X., Chen, P., van der Flier, L. G., Nakatsukasa, H., Neelapu, S. S., Chen, W., Clevers, H., Tian, Q., Qi, H., Wei, L. and Dong, C. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development (2014) Nature 507：513-518

14. Ichiyama, K., Chen, T., Wang, X., Yan, X., Kim, B. S., Tanaka, S., Ndiaye-Lobry, D., Deng, Y., Zou, Y., Zheng, P., Tian, Q., Aifantis, I., Wei, L. and Dong, C. The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells. (2015) Immunity 42： 613-626

15. Reynolds, J. M., Lee, Y.-H., Shi, Y., Angkasekwinai, P., Nallaparaju, K. C., Flaherty, S., Chang, S. H., Watarai, H. and Dong, C. Interleukin-17B antagonizes interleukin-25-mediated mucosal inflammation. (2015) Immunity 42：692-703

16. Li, J., Lee, Y., Li, Y., Jiang, Y., Lu, H., Zang, W., Zhao, X., Liu, L., Chen, Y., Tan, H., Yang, Z., Zhang, M. Q., Mak, T. W., Ni, L. and Dong, C. Co-inhibitory molecule B7 superfamily member 1 expressed by tumor-infiltrating myeloid cells induces dysfunction of anti-tumor CD8+ T cells (2018) Immunity 48: 773-786

17. Xu, M., Lu, H., Wu, Y., Liu, K., Shi, Y., An, H., Zhang, J., Wang, X., Lai, Y. and Dong, C. An IL-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation (2018) Immunity 48：787-798

18. Liu, X., Wang, Y., Lu, H., Li, J., Yan, X., Xiao, M., Hao, J., Hoang, O. N., Khong, H., Chen, T., Huang, R., Wu, J., Zhao, Q., Wu, Q., Xu, S., Wang, X., Jin, W., Yu, S., Wang, Y., Wei, L., Wang, A., Zhong, B., Ni, L., Liu, X., Nurieva, R., Ye, L., Tian, Q., Bian, X.-W. and Dong, C. Genome-wide analysis identifies Nr4a1 as a key mediator of T cell dysfunction (2019) Nature 567：525-529

19. Su, Y., Huang, J., Zhao, X., Lu, H., Wang, W., Yang, X. O., Shi, Y., Wang, X., Lai, Y. and Dong, C.Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation (2019) Science Immunology 4(36).

20. Xu, W., Zhao, X., Wang, X., Feng, H., Gou, M., Jin, W., Wang, X., Liu, X. and Dong C. The transcription factor Tox2 drives T follicular helper cell development via regulating chromatin accessibility (2019) Immunity 51: 826-839

21. Wang, X., Ni, L., Wan, S., Zhao, X., Ding, X., Dejean, A. and Dong, C. Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells. (2020)Immunity. 52:328-341.

22. Ni, L., Ye, F., Cheng, M.-L., Feng, Y., Deng, Y.-Q., Zhao, H., Wei, P., Ge, J., Gou, M., Li, X., Sun, L., Cao, T., Wang, P., Zhou, C., Zhang, R., Liang, P., Guo, H., Wang, X., Qin, C.-F., Chen, F. and Dong, C. Detection of SARS-CoV-2-specific humoral and celluar immnunity in COVID-19 convalescent individuals.(Report) (2020) Immunity. 52:971-977.

23. Chang, D., Xing, Q., Su, Y., Zhao, X., Xu, W., Wang, X. and Dong, C. The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation. (2020) Immunity. 53:614-626.

24. Huang, J., Lee, H. Y., Zhao, X., Han, J., Su, Y., Sun, Q., Shao, J., Ge, J., Zhao, Y., Bai, X., He, Y., Wang, X., Wang, X. and Dong, C. Interleukin-17D regulates group 3 innate lymphoid cell function through its receptor CD93. (2021) Immunity 54:673-686.