Biography

• Professor Fang Bing is engaged in clinical and basic research on dento-maxillofacial deformities and jaw defects. She has hosted over more than 10 projects including 1 Key Program and 4 General Programs of the National Natural Science Foundation of China. She has published 117 papers, including 62 SCI papers, many of which have been published in Int J Oral Sci, ACS Nano, CHEM ENG J, Biomaterials, AJO-DO and other top journals. She owns 20 patents (2 invention patents), 1 software copyright, 2 transformation. She edited 6 books including Mechanobiology in Stomatology and Orthognathic Surgery. She works as a Fellow of International College of Dentists (FICD), Fellow of Royal College of Surgeons of Edinburgh, United Kingdom, Director of the American Edward H. Angle Society of Orthodontist. She set up Chinese examination center and training center of Royal College of Surgeons of Edinburgh Membership in Orthodontics and opened international orthodontic training courses for countries along the Belt and Road, Shanghai Jiaotong University School of Medicine. She is an associate editor of Chinese Journal of Orthodontics and Shanghai Journal of Stomatology and editorial board member of Chinese Journal of Stomatology. She won the 2020 Xingyuan Rongyuan Award of the Ninth People's Hospital, the 2018-2021 Chief teacher of the Teaching Motivation Team of Shanghai Jiao Tong University, the 2017-2018 "The Bearer of Red Flag March 8" of Shanghai, and the 2021 Outstanding Member of the Communist Party of Shanghai Jiao Tong University, the first prize of the third Shanghai Medical Tree Award for Clinical Medical Science and Technology Innovation in 2020, the first prize of Shanghai Science and Technology Progress Award in 2018 (ranked fifth), the second prize of Science and Technology Progress Award of the Ministry of Education in 2018 (ranked fifth), the second prize of Shanghai Science and Technology Progress Award in 2013 (ranked second) and the second prize of Huaxia Medical Science and Technology Award in 2013 (ranked second) and other awards.

Publications

1. Jin Y, Liu Z, Li Z, Li H, Zhu C, Li R, Zhou T and Fang B*. Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1. Int J Oral Sci. 2022 Jul 14;14(1):34.

2. Yu F, Lian R, Liu L, Liu T, Bi C, Hong K, Zhang S, Ren J, Wang H, Ouyang N, Du LJ, Liu Y, Zhou L, Liu Y, Fang B*, Li Y, Duan SZ, Xia L. Biomimetic Hydroxyapatite Nanorods Promote Bone Regeneration via Accelerating Osteogenesis of BMSCs through T Cell-Derived IL-22. ACS Nano. 2022, 16: 755-770.

3. X. Wang, W. Guo, L. Li, F. Yu, J. Li, L. Liu, B Fang *, L. Xia, Photothermally triggered biomimetic drug delivery of Teriparatide via reduced graphene oxide loaded chitosan hydrogel for osteoporotic bone regeneration, Chemical Engineering Journal. 2021; 413: 127413.

4. Liu L, Liu Y, Feng C, Chang J, Fu R, Wu T, Yu F, Wang X, Xia L, Wu C, Fang B*. Lithium-containing biomaterials stimulate bone marrow stromal cell-derived exosomal miR-130a secretion to promote angiogenesis. Biomaterials. 2019; 192: 523-536.

5. Liu L, Yu F, Li L, Zhou L, Zhou T, Xu Y, Lin K, Fang B* and Xia L. Bone marrow stromal cells stimulated by strontium-substituted calcium silicate ceramics: release of exosomal miR-146a regulates osteogenesis and angiogenesis. Acta Biomater 2021; 119: 444-457.

6. Mao L, Xia L, Chang J, Liu J, Jiang L, Wu C, Fang B*. The synergistic effects of Sr and Si bioactive ions on osteogenesis, osteoclastogenesis and angiogenesis for osteoporotic bone regeneration. Acta Biomater. 2017; 61: 217-232.

7. Liu L, Wang X, Zhou Y, Cai M, Lin K, Fang B*, Xia L. The synergistic promotion of osseointegration by nanostructure design and silicon substitution of hydroxyapatite coatings in a diabetic model. J Mater Chem B. 2020;8(14):2754-2767.

8. Ouyang N, Zhao Y, Chen Q, Chen L, Fang B*, Dai J, Shen G. The effect of celecoxib in traumatic heterotopic ossification around temporomandibular joint in mice. Osteoarthritis Cartilage. 2020;28(4):502-515.

9. Yu F, Fu R, Liu L, Wang X, Wu T, Shen W, Gui Z, Mo X, Fang B*, Xia L. Leptin-Induced Angiogenesis of EA. Hy926 Endothelial Cells via the Akt and Wnt Signaling Pathways In Vitro and In Vivo. Front. Pharmacol. 2019; 10:1275.

10. Fu R, Han F, Liu L, Yu F, Gui Z, Wang X, Li B, Fang B*, Xia L. The Effects of Leptin on the Proliferation and Differentiation of Primary Chondrocytes in Vitro and Cartilage Regeneration in Vivo. ACS Biomater. Sci. Eng. 2019; 5: 1907−1919.

11. Nie P, Li Y, Suo H, Jiang N, Yu D, Fang B*. Dasatinib Promotes Chondrogenic Differentiation of Human Mesenchymal Stem Cells via the Src/Hippo-YAP Signaling Pathway. ACS Biomaterials-Science & Engineering. 2019;5(10):5255-5265.

12. Dong T, Yuan L, Liu L, Qian Y, Xia L, Ye N, Fang B*. Detection of alveolar bone defects with three different voxel sizes of cone-beam computed tomography: an in vitro study. Sci Rep. 2019; 9(1): 8146.

13. Dai Q, Zhou S, Zhang P, Ma X, Ha N, Yang X, Yu Z, Fang B*, Jiang L. Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats. Sci Rep. 2017; 7(1): 3906.

14. Jin Y, Li Z, Wu Y, Li H, Liu Z, Liu L, Ouyang N, Zhou T, Fang B* and Xia L. Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3. J Inflamm Res 2021, 14: 6067-6083.

15. Li J, Guo W, Yu F, Liu L, Wang X, Li L, Fang B*, Xia L. Low-intensity pulsed ultrasound promotes angiogenesis via the AKT pathway and DNA methylation in human umbilical vein endothelial cells. Ultrasonics 2021 Aug 25;118.

16. Fu R; Wang X; Xia L, Tan Y, Liu J, Yuan L, Yang Z, Fang B*. ADAM10 modulates SOX9 expression via N1ICD during chondrogenesis at the cranial base. RSC ADVANCES. 2018; 8(67): 38315-38323.

17. Dong T, Wang X, Xia L, Yuan L, Ye N and Fang B*. Accuracy of different tooth surfaces on 3D printed dental models: orthodontic perspective. BMC Oral Health 2020; 20(1): 340.

18. Dong T, Xia L, Cai C, Yuan L, Ye N, Fang B*. Accuracy of in vitro mandibular volumetric measurements from CBCT of different voxel sizes with different segmentation threshold settings. BMC Oral Health. 2019; 19(1): 206.

19. Ouyang N, Zhang P, Fu R, Shen G, Jiang L, Fang B*. Mechanical strain promotes osteogenic differentiation of bone mesenchymal stem cells from ovariectomized rats via the phosphoinositide 3‑kinase/Akt signaling pathway. Mol Med Rep. 2018; 17(1): 1855-1862.

20. Sun L, Yuan L, Wang B, Zhang L, Shen G, Fang B*. Changes of alveolar bone dehiscence and fenestration after augmented corticotomy-assisted orthodontic treatment: a Ha N, Hong Y, Qu L, Chung M, Qu R, Cai X, Fang B*, Jiang L. Evaluation of post-surgical stability in skeletal class II patients with idiopathic condylar resorption treated with functional splint therapy. J Craniomaxillofac Surg. 2020;48(3):203-210.

21. Miao Z, Wang X, Mao L, Xia Y, Yuan L, Cai M, Liu J, Wang B, Yang X, Zhu L, Yu H, Fang B*. Influence of temporomandibular joint disc displacement on mandibular advancement in patients without pre-treatment condylar resorption. Int J Oral Maxillofac Surg. 2017; 46(3): 328-336.

22. Wang J, Yuan L, Liu J, Mao L, Xia L, Fang B*. Hemifacial microsomia treated with a hybrid technique combining distraction osteogenesis and a mandible-guided functional appliance: Pilot study. Am J Orthod Dentofacial Orthop. 2019; 155(6): 801-811.

23. Xiaoting Wang, Lunguo Xia, Jiayi Li, Lvyuan Li, Fei Yu, Lingjun Yuan, Bing Fang*, and Niansong Ye. Accuracy of dental arch form in customized fixed labial orthodontic appliances. Am J Orthod Dentofacial Orthop. 2022; S0889-5406(22)00105-6.

24. Ye N, Wu T, Dong T, Yuan L, Fang B*, Xia L. Precision of 3D-printed splints with different dental model offsets. Am J Orthod Dentofacial Orthop. 2019; 155(5): 733-738.

25. Dong T, Ye N, Yuan L, Wu S, Xia L, Fang B*. Assessing the Influence of Chin Asymmetry on Perceived Facial Esthetics With 3-Dimensional Images. J Oral Maxillofac Surg. 2020; S0278-2391(20)30311-6.

26. Yu Fei, Liu Lu, Xia Lunguo, Fang B*. Establishment of a C57BL/6 Mandibular Critical-Size Bone Defect Model. JOURNAL OF CRANIOFACIAL SURGERY. 2021,32: 2562-2565.

27. Wang B, Shen G, Guo Q, Fang B*, Yu H. Long-term Effects of Augmented Corticotomy-Assisted Orthodontics in Patients with Mandibular Anterior Alveolar Defect. J Craniofac Surg. 2019;30(8):e737-e740.

28. Wang B, Wu Y, Yu H, Jiang L, Fang B*, Guo Q. The effects of NELL on corticotomy-assisted tooth movement and osteogenesis in a rat model. Biomed Mater Eng. 2018; 29(6): 757-771.