Reactive oxygen species-related protein modifications and cell signaling

Autophagy: structure, function and regulation

Medical cell biology

Techniques in cell biology 3.Molecules, cells and tissues (an integrated course for basic medicine in SJTU)

1978.02-1982.12  Shanghai Second Medical College, Pediatrics, Bachelor

1987.07-1990.07  Shanghai Second Medical University, Biophysics, Master

1991.07-1994.07  Shanghai Second Medical University, Histology and Embryology, Ph.D

1983.1-1987.7  Residence, Shanghai 1stTextile Hospital, Department of Pediatrics

1990.7-1995.10  Lecturer, Shanghai Second Medical University, Department of Biophysics

1993.10-1994.10  Post-doctorial fellow, INSERM U.28, Paris, France

1995.10-2002.10 Associate Professor, Shanghai Second Medical University, Department of Cell Biology

2001.10-2002.10  Senior Visiting Scholar, University of Illinois at Chicago, Chicago, USA

2002.10-2021.12  Professor, Shanghai Second Medical University (Shanghai Jiao Tong University School of Medicine since 2005), Department of Cell Biology (Department of Biochemistry and Molecular Cell Biology since 2008)

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Yi J, Yang J, He R, Gao F, Sang HR., Tang XM, Ye RD. Emodin enhances arsenic trioxide-induced apoptosis via generation of reactive oxygen species and inhibition of survival signaling. Cancer Res. 2004, 64(1): 108-116.

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Jing Y, Yang J, Wang Y, Li H, Chen Y, Hu Q, Shi G, Tang X, Yi J. Alteration of subcellular redox equilibrium and the consequent oxidative modification of nuclear factor kappaB are critical for anticancer cytotoxicity by emodin, a reactive oxygen species-producing agent. Free Radic Biol Med, 2006, 40(12):2183-97.

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Zuo Y, Xiang B, Yang J, Sun X, Wang Y, Cang H, Yi J. Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1. Cell Res, 2009, 19(4):449-457.

Huang C, Han Y, Wang Y, Yan S, Sun XX, Yeh ET, Chen Y, Cang H, Li H, Cheng J, Tang XM, Yi J. SUMO-specific protease 3 is responsible for HIF-1 transactivation under mild oxidative stress via P300 de-SUMOylation. EMBO J. 2009, 28(18):2748-2762.

Han Y, Huang C, Sun X, Xiang B, Wang M, Yeh ET, Chen Y, Li H, Shi G, Cang H, Sun Y, Wang J, Wang W, Gao F, Yi J. SENP3-mediated de-conjugation of SUMO2/3 from PML is correlated with accelerated cell proliferation under mild oxidative stress. J Biol Chem, 2010, 285(17):12906-12915.

Yan S, Sun X, Xiang B, Cang C, Kang X, Chen Y, Li H, Shi G, Yeh ETH, Wang B, Wang X Yi J, Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90. EMBO J, 2010, 29(22):3773-86.

Wang Y, Yang J, Yi J. Redox sensing by proteins: oxidative modifications on cysteines and the consequent events. Antioxid Redox Signal. 2012, 16(7): 649-57, (Forum Review Article).

Wang M, Sang J, Ren Y, Liu K, Liu X, Zhang J, Wang H, Wang J, Orian A4, Yang J, Yi J. SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation. Protein Cell. 2016, 7(1):63–77.

Zhou Z, Wang M, Li J, Xiao M, Chin YE, Cheng J, Yeh ET, Yang J, Yi J. SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer. Oncogene. 2016, 35(45): 5826–5838

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Lao Y, Yang K, Wang Z, Sun X, Zou Q, Yu X, Cheng J, Tong X, Yeh ET, Yang J, Yi J. DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages. J Biol Chem. 2018, 293(11):3965-3980.

Liu K, Guo C, Lao Y, Yang J, Zhao Y, Yang Y, Yang J, Yi J. A fine-tuning mechanism underlying self-control for autophagy: deSUMOylation of BECN1 by SENP3. Autophagy, 2020,16(6):975-990.

Yu B, Lin Q, Huang C, Zhang B, Wang Y, Jiang Q, Zhang C, Yi J. SUMO proteases SENP3 and SENP5 spatiotemporally regulate the kinase activity of Aurora A. J Cell Sci. 2021, 134(13): jcs249771.