Biography

• Yanyun Zhang received his M.D. and Ph.D. degrees from The University of Tokyo and is a professor of Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine; professor, principal investigator of Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences; chief scientist of National Program on Key Basic Research Project of China (973 Program); vice-chairman of Advisory Committee of Sino American Cancer Association; vice-chief editor of Current Immunology. He was the vice-director of Institute of Health sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences and has extensive organizational and management experience with national major scientific research projects, frontier strategy project of Chinese Academy of Sciences, etc. His research focus on stem cell immunology, tumor immunology, inflammatory microenvironment and disease, new strategies for immunological therapy, etc., which has the advantage of interdisciplinarity. Especially, he has established systematic academic theoretical achievements in the fields of radioimmune protection and stem cell immunology, and has achieved important innovative breakthroughs in mesenchymal stem cell therapy mechanism research and clinical treatment application. He was responsible for National Program on Key Basic Research Project of China (973 Program), Major Program of National Natural Science Foundation of China; National Major Scientific and Technological Special Project for “Significant New Drugs Development”; Strategic Priority Research Program of the Chinese Academy of Sciences; Shanghai major/key scientific and technological research projects etc.

Selected Publications

1. Zhao F, Zhang Y, Wang H, Jin M, He S, Shi Y, Guo Y, Zhang Y. Blockade of osteopontin reduces alloreactive CD8+ T cell-mediated graft-versus-host disease. Blood. 2011 Feb 3;117(5):1723-33.

2. Zhang Y, Cai W, Huang Q, Gu Y, Shi Y, Huang J, Zhao F, Liu Q, Wei X, Jin M, Wu C, Xie Q, Zhang Y, Wan B, Zhang Y. Mesenchymal stem cells alleviate bacteria-induced liver injury in mice by inducing regulatory dendritic cells. Hepatology. 2014 Feb;59(2):671-82.

3. Dang S, Xu H, Xu C, Cai W, Li Q, Cheng Y, Jin M, Wang RX, Peng Y, Zhang Y, Wu C, He X, Wan B, Zhang Y. Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis. Autophagy. 2014 Jul;10(7):1301-15.

4. Huang Q, He S, Tian Y, Gu Y, Chen P, Li C, Huang J, Liu Y, Yu H, Jin M, Hu S, Tong Q, Ma A, Jin J, Hexner E, Fung H, Reshef R, Zhang Y, Zhang Y. Hsp90 inhibition destabilizes Ezh2 protein in alloreactive T cells and reduces graft-versus-host disease in mice. Blood. 2017 May 18;129(20):2737-2748.

5. Zhang J, Huang J, Gu Y, Xue M, Qian F, Wang B, Yang W, Yu H, Wang Q, Guo X, Ding X, Wang J, Jin M, Zhang Y. Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells. Cell Mol Immunol. 2021 Jun;18(6):1476-1488.