Basic research：Gastrointestinal tumor microenvironment；

Clinical research: the early diagnosis and discovery of gastrointestinal tumors; the individualized treatment of Helicobacter pylori infection; digestive endoscopy diagnosis and treatment.

The effect and mechanism of XAF1 gene in reversing TRAIL resistance in hepatocellular carcinoma (National Natural Science Foundation of China,2011-2013)

The role of KIAA1199 promoting gastric cancer cell growth and cancer stem cell reprogramming (Science and Technology Foundation of Shanghai Jiao Tong University School of Medicine,2014-2016)

1.Zhu L#, Cheng X#, Shi J , Lin J , Chen G, Jin H, Liu AB, Pyo H, Ye J, Zhu Y, Wang H, Chen H, Fang J, Cai L, Wang TC, Yang CS, Tu SP. Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis.Oncogene.2016;35  (41):5388-5399.(IF7.932)

Zhu LM*, Shi DM, Dai Q, Cheng XJ, Yao WY, Sun PH, Ding Y, Qiao MM, Wu YL, Jiang SH, Tu SP*. Tumor suppressor XAF1 induces apoptosis, inhibits angiogenesis and inhibits tumor growth in hepatocellular carcinoma. Oncotarget. 2014, 5(14):5403-15.(IF 6.359)

Zhu L, Cheng X, Ding Y,Shi J, Jin H, Wang H, Wu Y, Ye J, Lu Y, Wang TC, Yang CS, Tu SP. Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway. Cancer Letters.2014, 343(1):80-89.(IF 5.621)