Biography

• Dr. Jiang received his Ph.D degree in Pathological Biology from Fudan Univeristy, Shanghai, in 2018. Afterwards, he joined in Shanghai Cancer Institute, Ren Ji Hospital, Shanghai Jiao Tong University. His major research interests are the secreted factors in tumor microenvironment including extracellular matrix (ECM), stromal cells, cytokines, hormones, neurotransmitters, etc. He has published about 30 peer-reviewed paper and a textbook on cancer biology and tumor microenvironment. As a yourger principal investigator, he has been granted by Shanghai "Sailing Project", "Chenguang Project", the National Science Foundation of China, etc. Related research works were published in journals such as Gastroenterology, Gut, Nature Communications, Clinical Cancer Research, Molecular Cancer, Oncogene and Theranostics by the first and corresponding authors. Served as a young member of the Tumor Microenvironment Professional Committee of the Chinese Anti-Cancer Association. Won the honorary titles of the 8th Academic Star of Fudan University, the 2018 Shanghai Outstanding Graduates, the first prize of the 3rd National Pancreatic Tumor Conference and the second prize of the 17th Shanghai Medical Science and Technology Award.

Publications

1. Jiang SH#, Li J#, Dong FY#, Yang JY, Liu DJ, Yang XM, Wang YH, Yang MW, Fu XL, Zhang XX, Li Q, Pang XF, Huo YM, Li J, Zhang JF, Lee HY, Lee SJ, Qin WX, Gu JR, Sun YW*, Zhang ZG*. Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells Under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice, Gastroenterology, 2017, 153(1): 277-291.

2. Jiang SH#, Zhu LL#, Zhang M#, Li RK#, Yang Q#, Yan JY, Zhang C, Yang JY, Dong FY, Dai M, Hu LP, Li J, Li Q, Wang YH, Yang XM, Zhang YL, Nie HZ, Zhu L, Zhang XL, Tian GA, Zhang XX, Cao XY, Tao LY, Huang S, Jiang YS, Hua R, Qian Luo K, Gu JR, Sun YW*, Hou S*, Zhang ZG*. GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca2+ signalling in a GABA-independent manner, Gut, 2019, 68(11): 1994-2006.

3. Li R#, Wang Y#, Zhang X, Feng M, Ma J, Li J, Yang X, Fang F, Xia Q, Zhang Z*, Shang M*, Jiang SH*. Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis, Molecular Cancer, 2019, 18(1): 18.

4. Zhang XL#, Hu LP#, Yang Q#, Qin WT#, Wang X, Xu CJ, Tian GA, Yang XM, Yao LL, Zhu L, Nie HZ, Li Q, Xu Q, Zhang ZG, Zhang YL*, Li J*, Wang YH*, Jiang SH*. CTHRC1 promotes liver metastasis by reshaping infiltrated macrophages through physical interactions with TGF-β receptors in colorectal cancer, Oncogene. 2021 Jun;40(23):3959-3973.

5. Jiang SH#, Hu LP#, Wang X, Li J, Zhang ZG*. Neurotransmitters: emerging targets in cancer. Oncogene. 2020 Jan;39(3):503-515.

6. Jiang SH#, Zhang S#, Wang H#, Xue JL*, Zhang ZG*. Emerging experimental models for assessing perineural invasion in human cancers. Cancer Lett. 2022 Jun 1;535:215610.

7. Jiang SH#, Liu D#, Hu LP#, Zhang S#, Yu Y, Sun YW*, Ji J*, Zhang ZG*. Modeling of cancer-related body-wide effects identifies LTB4 as a diagnostic biomarker for pancreatic cancer. EBioMedicine. 2022 Jun;80:104050.

8. Jiang SH#, Li RK#, Liu DJ#, Xue JL#, Yu MH#, Zhang S, Liu LM, Zhang JF, Hua R, Sun YW, Wang X*, Yang Q*, Zhang ZG*. The genomic, transcriptomic, and immunological profiles of perineural invasion in pancreatic ductal adenocarcinoma. Sci China Life Sci. 2022 Jul 6. doi: 10.1007/s11427-022-2146-5.

9. Yu M#, Wang H#, Zhao W#, Ge X, Huang W, Lin F, Tang W, Li A, Liu S, Li RK*, Jiang SH*, Xue J*. Targeting type Iγ phosphatidylinositol phosphate kinase overcomes oxaliplatin resistance in colorectal cancer. Theranostics. 2022 May 20;12(9):4386-4398.

10. Wang X#, Hu LP#, Qin WT#, Yang Q#, Chen DY#, Li Q, Zhou KX, Huang PQ, Xu CJ, Li J, Yao LL, Wang YH, Tian GA, Yang JY, Yang MW, Liu DJ, Sun YW*, Jiang SH*, Zhang XL*, Zhang ZG*. Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis. Nat Commun. 2021 Jan 8;12(1):174.