Shanghai Cancer Institute

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SUN Ying

Associate  Professor

Email:ysun@shsci.org

phone:021-64437181

Research field:

1. The delivery system to overcome drug resistance

2. Design and application of new drug/gene delivery system

Biography

  • Ying Sun graduated from Donghua University in 2008 with a doctorate in material sciences and engineering and then joined the State Key Laboratory of Oncogenes and Related Genes of Shanghai Cancer Institute. She has been engaged in the research of anti-tumor drug delivery system. Ying Sun undertook 4 projects supported by National Natural Science Foundation of China and 2 project supported by Nature Science Foundation of Shanghai, participated in 3 projects supported by National Natural Science Foundation of China and 2 projects supported by NanoScience and Technology from the Science and Technology Commission of Shanghai Municipality as the principal researcher. Won the third prize of Shanghai Science and Technology Award. Ying Sun participated in the publication of more than 60 papers, and published more than 30 articles in ACS Nano, Biomaterials, Journal of Materials Chemistry and other journals as the first author and corresponding author. Obtained 12 granted patents.

Publications

  1. Xupeng Yang, Meng Zhao, Zhihua Wu, Chuanrong Chen, Yanhua Zhang, Liting Wang, Qianqian Guo, Quan Wang, Shunshun Liang, Suxian Hu, Yourong Duan*, Ying Sun*. Nano-ultrasonic Contrast Agent for Chemoimmunotherapy of Breast Cancer by Immune Metabolism Reprogramming and Tumor Autophagy. ACS Nano. 2022, 16: 3417-3431.

  2. Meng Zhao, Xupeng Yang, Hao Fu, Chuanrong Chen, Yanhua Zhang, Zhihua Wu, Yourong Duan, Ying Sun*. Immune/Hypoxic Tumor Microenvironment Regulation-Enhanced Photodynamic Treatment Realized by pH-Responsive Phase Transition-Targeting Nanobubbles. ACS Appl. Mater. Interfaces. 2021, 13: 32763-32779.

  3. Yanhua Zhang, Yang Dong, Hao Fu, Hui Huang, Zhihua Wu, Meng Zhao, Xupeng Yang, Qianqian Guo, Yourong Duan*, Ying Sun*. Multifunctional tumor-targeted PLGA nanoparticles delivering Pt(IV)/siBIRC5 for US/MRI imaging and overcoming ovarian cancer resistance. Biomaterials. 2021, 120478.

  4. Yunkai Zhu#, Ying Sun#, Weiyong Liu, Wenbin Guan, Huanhuan Liu, Yourong Duan*, Yaqing Chen*. Magnetic polymeric nanobubbles with optimized core size for MRI/ultrasound bimodal molecular imaging of prostate cancer. Nanomedicine. 2020, 15(30): 2901-2916.

  5. Hui Huang, Yang Dong, Yanhua Zhang, Dan Ru, Zhihua Wu, Jiali Zhang, Ming Shen, Yourong Duan*, Ying Sun*. GSH-sensitive Pt(IV) prodrug-loaded phase-transitional nanoparticles with a hybrid lipid-polymer shell for precise theranostics against ovarian cancer. Theranostics. 2019, 9(4): 1047-1065.

  6. Yanhua Zhang#; Hui Huang#; Hao Fu; Meng Zhao; Zhihua Wu; Yang Dong; He Li; Yourong Duan; Ying Sun*; Dual-mode US/MRI nanoparticles delivering siRNA and Pt(IV) for ovarian cancer treatment, RSC Advances, 2019, 9: 33302.

  7. Jie Xu#, Ying Sun#, Zeting Yuan#, Yijie Bao, Rongxin Li, Cheng Liu, YanYan Qiu, Ke Xu, Xiaojing Shi, Hui Yu, Teng Chen*, Yourong Duan*, Peihao Yin*. Bufalin-Loaded CaP/DPPE-PEG-EGF Nanospheres: Preparation, Cellular Uptake, Distribution, and Anti-Tumor Effects. Journal of Biomedical Nanotechnology. 2019, 15: 329-339.

  8. Ying Sun#, Qi Wang#, Jianhua Chen, Lei Liu, Li Ding, Ming Shen, Jin Li, Baoshan Han, Yourong Duan. Temperature-Sensitive Gold Nanoparticle-Coated Pluronic-PLL Nanoparticles for Drug Delivery and Chemo-Photothermal Therapy. Theranostics. 2017, 7(18): 4424-4444.

  9. Jianhua Chen, Pei Gao, Sujing Yuan, Rongxin Li, Aimin Ni, Liang Chu, Li Ding, Ying Sun*, Xinyuan Liu*, Yourong Duan*. Oncolytic Adenovirus Complexes Coated with Lipids and Calcium Phosphate for Cancer Gene Therapy. ACS Nano. 2016, 10: 11548-11560.

  10. Ying Sun#, Yunkai Zhu#, Can Huang, Rongxin Li, Yaqing Chen, Youron Duan. Magnetite loaded Polypeptide-PLGA multifunctional microbubbles for dual-mode US/MR imaging. Contrast Media & Molecular Imaging. 2016. 11(2): 146-153.

  11. Yunkai Zhu#, Ying Sun#, Yaqing Chen, Weiyong Liu, Jun Jiang,Wenbin Guan, Zhongyang Zhang, Yourong Duan. In Vivo Molecular MRI Imaging of Prostate Cancerby Targeting PSMA with Polypeptide-Labeled Superparamagnetic Iron OxideNanoparticles. International Journal of Molecular Sciences. 2015, 16: 9573-9587.

  12. Zelai He#, Ying Sun#, Qi Wang, Ming Shen, Mingjie Zhu, Fengqian Li, Yourong Duan. Degradation and Bio-Safety Evaluation of mPEG-PLGA-PLL Copolymer-Prepared Nanoparticles. Journal of Physical Chemistry C. 2015, 119: 3348-3362.