LIU Yongzhong
Professor
Email: liuyzg@shsci.org
Tel：86-21-34206283
Research field：Exploration of events essential for tumor immune tolerance and of Research Interests; Role of dysregulated ubiquitination processes in tumorigenesis and malignant progress.
Biography
Dr. Liu received his Ph.D. degree in 2003 from Fudan University, China and completed his postdoctoral training at Roswell Park Cancer Institute and National Institutes of Health in USA from 2003 through 2008. He was recruited to the State-key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine in 2008, and he is now a professor and principal investigator of the Cancer Immunoregulation Section.
Publications:
Yang Z, Xu G, Wang B, Liu Y, Zhang L, Jing T, Tang M, Xu X, Jiao K, Xiang L, Fu Y, Tang D, Zhang X, Jin W, Zhuang G, Zhao X, Liu Y. USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade. Nat Commun. 11;12(1):4852. (2021)
Xu G, Yang Z, Ding Y, Liu Y, Zhang L, Wang B, Tang M, Jing T, Jiao K, Xu X, Chen Z, Xiang L, Xu C, Fu Y, Zhao X, Jin W, Liu Y. The deubiquitinase USP16 functions as an oncogenic factor in K-RAS-driven lung tumorigenesis. Oncogene. 40(36):5482-5494 (2021).
Liu Y, Zhang L, Wang B, Yang Z, Xu G, Ma A, Tang M, Jing T, Wu L, Xu X, Liu Y. Requirement for POH1 in differentiation and maintenance of regulatory T cells. Cell Death Differ. 26, 751-762(2019).
Ma A, Tang M, Zhang L, Wang B, Yang Z, Liu Y, Xu G, Wu L, Jing T, Xu X, Yang S, Liu Y. USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis. Oncogene. 38, 2405-2419(2019).
Zhang L, Liu Y, Wang B, Xu G, Yang Z, Tang M, Ma A, Jing T, Xu X, Zhang X, Liu Y. POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity. Nat Commun. 1, 4225 (2018).
Wang B, Ma A, Zhang L, Jin WL, Qian Y, Xu G, Qiu B, Yang Z, Liu Y, Xia Q, Liu Y. POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation. Nat Commun. 6, 8704（2015）.
Zhang L, Yang Z, Ma A, Qu Y, Xia S, Xu D, Ge C, Qiu B, Xia Q, Li J, Liu Y. Growth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma. Hepatology. 59,178-89 (2014).
Liu Y, Xu Y, Sun J, Ma A, Zhang F, Xia S, Xu G, Liu Y. AKT hyperactivation confers a Th1 phenotype in thymic Treg cells deficient in TGF-β receptor II signaling. Eur J Immunol. 2014 Feb;44(2):521-32.
Li J, Liu Y, Wang B, Xu Y, Ma A, Zhang F, Ge C, Yang Z, Li J, Liu Y. Myeloid TGF-β signaling contributes to colitis-associated tumorigenesis in mice. Carcinogenesis. 2013 Sep;34(9):2099-108.
Liu Y, Zhang P, Li J, Kulkarni AB, Perruche S, Chen W. A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat Immunol. 2008 Jun;9(6):632-40.
