LAN Pengfei
Professor
Research direction：RNA metabolism；ribozyme； ribonucleoprotein complex structure and function
E-mail：pengfeilan@@shsmu.edu.cn
Lab: http://www.shipm.cn/jyjz_web/html/jyjz_English/jyjz_eg_lmz_sysjj/List/index.htm
Research Interests
The RNA molecule plays pivotal roles in a vast array of cellular processes. As a magic molecule, many RNAs are terminal gene products that do not code for proteins. Over 75% of our genome encodes highly conserved non-coding RNA molecules, compared with only ＜2% that encodes proteins. They may perform much diversified roles, such as regulating other RNAs and proteins, catalyzing chemical reactions, guiding other RNAs to their place of action or silencing the gene expression. RNA is never existed as naked molecules in the cell. They often assembled with the proteins to form ribonucleoprotein (RNP) complexes. Our lab is investigating the RNP complexes which play important roles in the physiological and pathological processes by using multiple approaches including the structural， biochemical，genetic and imaging tools.
Education and Work Experience
Education：
2006/09-2010/06， B.Sc., College of Life Science, Jilin University, Changchun, China
2010/09-2015/12，Ph.D. in Biochemistry and Molecular Biology, National Institute of Biological Science, Beijing, China
Work Experience:
2016/01-2017/11，Postdoc, National Center of Protein Science, Shanghai，China
2017/11-2018/11，Assistant Investigator, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2018/12-2019/12，Associate Investigator, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2020/01-Present, Principle Investigator, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Selected Publications
Lan, P., B. Zhou, M. Tan, S. Li, M. Cao, J. Wu* and M. Lei* (2020). "Structural insight into precursor ribosomal RNA processing by ribonuclease MRP." Science eabc0149.
Wan, F., Q. Wang, J. Tan, M. Tan, J. Chen, S. Shi, P. Lan*, J. Wu* and M. Lei* (2019). Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme." Nature Communications 10(1): 2617.
Jian, W., Shuangshuang, N., Ming, T., Chenhui, H., Qianmin, W., Pengfei, L.*, and Ming, L*. Cryo-EM structure of the human Ribonuclease P holoenzyme. Cell, 175(5): 1393-1404.
Lan, P.#, M. Tan#, Y. Zhang#, S. Niu, J. Chen, S. Shi, S. Qiu, X. Wang, X. Peng, G. Cai, H. Cheng, J. Wu, G. Li and M. Lei (2018). Structural insight into precursor tRNA processing by yeast ribonuclease P. Science, 362(6415): eaat6678.
Sanduo Zheng#，Pengfei Lan#，Ximing Liu，Keqiong Ye*. (2014). Interaction between ribosome assembly factors Krr1 and Faf1 is essential for formation of small ribosomal subunit in yeast, Journal of Biological Chemistry, 289(33): 22692~22703.
