HUANG Chenhui
Associate Professor
Research direction：Mammalian spermatogenesis; Telomere structure and function
E-mail：huangchh@shsmu.edu.cn
Lab: http://www.shipm.cn/jyjz_web/html/jyjz_English/jyjz_eg_lmz_sysjj/List/index.htm
Research Interests
Mammalian spermatogenesis is a unique cell differentiation process including mitosis, meiosis and spermiogenesis. During meiosis prophase I, telomeres are implicated in the regulation of homologous paring and synapsis. By structural biology studies and mouse model analysis, we aim to reveal the structural basis and molecular mechanism of telomere associated protein complexes in regulating homolog pairing and synapsis. Spermiogenesis is the development of spermatids into mature spermatozoa that possess specific morphology and structure to ensure the effective sperm-egg recognition and fusion. Many cases of male infertility involve abnormal sperm structures, and some of them are caused by genetic mutations. By analysis of mouse models, we aim to unveil the pathogenic mechanism of related gene mutations to provide theoretical guidance for the clinical diagnosis and treatment of patients with malformed spermatozoa.
Education and Work Experience
Academic Positions：
(1) 2017.9-now, Shanghai 9th People’s Hospital, Shanghai JiaoTong University School of Medicine, Research Associate Professor
(2) 2014.5-2017.8, SIBCB, Shanghai Institutes for Biological Sciences, Research Associate Professor
(3) 2009.7-2013.12, SMB, Washington State University, USA, Research Fellow
(4) 2005.2-2008.8, ICM, Uppsala University, Sweden, Research Fellow
Education:
(1) 1998.9–2004.7, College of Life Sciences, Peking University, Botany, Ph.D.
(2) 1994.9–1998.7, College of Life Sciences, Peking University, Plant Developmental and Molecular Biology, Bachelor
Selected Publications
Wang Y#, Chen Y#, Chen J, Wang L, Nie L, Long J, Chang H, Wu J, Huang C* and Lei M*, The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope. Nat Commun, 2019. 10(1): p. 564.
Wu J#, Niu S#, Tan M#, Huang C, Li M, Song Y, Wang Q, Chen J, Shi S, Lan P* and Lei M*, Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Cell, 2018. 175(5): p. 1393-1404 e11.
Long J#, Huang C#, Chen Y, Zhang Y, Shi S, Wu L, Liu Y, Liu C, Wu J* and Lei M*, Telomeric TERB1-TRF1 interaction is crucial for male meiosis. Nat Struct Mol Biol, 2017. 24(12): p. 1073-1080.
Huang C, Jia P, Chastain M, Shiva O and Chai W, The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells. Experimental Cell Research, 2017. 355(2): p. 95-104.
Hu C#, Rai R#, Huang C, Broton C, Long J, Xu Y, Xue J, Lei M*, Chang S* and Chen Y*, Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex. Cell Res, 2017. 27(12): p. 1485-1502.
