Research Interests

• Research of my lab focuses on understanding the molecular machinery and mechanisms underlying the 3D organization of eukaryotic genomes and the physiological impacts of 3D genome organization in ageing, reproduction and development. I am also interested in developing new genomic and imaging methods for characterizing genome organization at greater molecular detail.

Education and Work Experience

• Oct 2017- Present, Principal Investigator, Shanghai Institute of Precision Medicine/ Shanghai Jiao Tong University School of Medicine

• July 2011- Oct 2017, Postdoc, Department of Molecular and Cell Biology, University of California, Berkeley

• Sep 2004- May 2011, Ph.D., Program of Biophysics and Computational Biology, University of Illinois, Urbana-Champaign

• Sep 1998- Jun 2003, B.S., Special Class for Gifted Youth / School of Life Sciences, University of Science and Technology of China

Selected Publications

1. Zuo W*, Chen G*, Gao Z*, Li S, Chen Y, Huang C, Chen J, Chen Z, Lei M#, Bian Q#, “Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment”, Nat Commun. 2021 Oct 8, 12(1):5827. (# Corresponding author)

2. Bian Q*, Anderson EC*, Yang Q, Meyer BJ，“Histone H3K9 methylation promotes formation of genome compartments in C. elegans via chromosome compaction and perinuclear anchoring” PNAS 2020, 117(21):11459-11470 (* Equal contribution.)

3. Brejc K*, Bian Q*, Uzawa S, Wheeler BS, Anderson EC, King DS, Kranzusch P, Preston CG, Meyer BJ, “Dynamic control of X-chromosome conformation and repression by a histone H4K20 demethylase” Cell 2017, 171:85–102.e23 (* Equal contribution.)

4. Crane E*, Bian Q*, McCord RP*, Lajoie BR*, Wheeler BS, Ralston EJ, Uzawa S, Dekker J, Meyer BJ, “Condensin-driven remodelling of X chromosome topology during dosage compensation” Nature 2015, 523:240-44 (* Equal contribution.)

5. Bian Q, Khanna N, Alvikas J, Belmont AS, “β-Globin cis-elements determine differential nuclear targeting through epigenetic modifications” J Cell Biol. 2013, 203(5):767-83

6. Bian Q and Belmont AS, “Revisiting higher-order and large-scale chromatin organization” Curr Opin Cell Biol. 2012

7. 24(3):359-66.

8. Bian Q and Belmont AS, “BAC TG EXPRESS: One step method for high-level, copy number dependent, position independent transgene expression” Nucleic Acids Res. 2010, 38 (11): e127.