Li Shengxian, phD & MD, Associate Chief Physician, Graduate Supervisor

Deputy Director, Department of Endocrinology and Metabolism, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine. Member of the 11th Youth Committee of the Endocrine Branch of the Shanghai Medical Association, deputy head of the Basic Science Group. Mainly engaged in individualized blood glucose control, clinical diagnosis and treatment of polycystic ovary syndrome (PCOS), thyroid, adrenal and other endocrine diseases. Research interests: 1. Metabolic disorder and female reproductive dysfunction (Polycystic ovary syndrome)；2. the mechanism of adipose-derived mesenchymal stem cells to improve islet function and islet transplantation. Publications: more than 40 SCI articles, including 22 articles in the name of the first author or the corresponding author.

Li SX#, Liu W*, Wang LH, et al. Effects of menopause on hepatic 11beta-HSD1 activity and adrenal sensitivity to adrenocorticotropin in healthy non-obese women. Gynecological Endocrinology. 2011, 27(10):794-799.

Tao T#, Li S#, Zhao A, Mao X, Liu W. Early impaired β-cell function in chinese women with polycystic ovary syndrome. Int J Clin Exp Pathol. 2012;5(8):777-86. PMID: 23071860

Tao T#, Li S#, Zhao A, Zhang Y, Liu W*. Expression of the CD11c gene in subcutaneous adipose tissue is associated with cytokine level and insulin resistance in women with polycystic ovary syndrome. Eur J Endocrinol. 2012 Nov;167(5):705-13. PMID: 22945299

Wang L#, Li S#, Zhao A, Tao T, Mao X, Zhang P, Liu W*. The expression of sex steroid synthesis and inactivation enzymes in subcutaneous adipose tissue of PCOS patients. J Steroid Biochem Mol Biol. 2012 Oct;132(1-2):120-6. PMID: 22381227

Li S#, Tao T#, Wang L, Mao X, Zheng J, Zhao A, Liu W*. The expression of 11β-HSDs, GR, and H6PDH in subcutaneous adipose tissue from polycystic ovary syndrome subjects. Horm Metab Res. 2013 Oct;45(11):802-807. PMID: 23979790

Cao HM#, Ye XP#, Ma JH#, Jiang H#, Li SX#, Li RY#, Li XS, Guo CC, Wang ZQ, Zhan M, Zuo CL, Pan CM, Zhao SX, Zheng CX, Song HD. Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling. EBioMedicine. 2015 Sep 28;2(11):1718-24. doi: 10.1016/j.ebiom.2015.09.044. eCollection 2015.

Lin T#, Li S#, Xu H, Zhou H, Feng R, Liu W, Sun Y, Ma J*. Gastrointestinal hormone secretion in women with polycystic ovary syndrome: an observational study. Hum Reprod. 2015 Nov;30(11):2639-44. PMID: 26373789

Huang R#, Yue J#, Sun Y, Zheng J, Tao T, Li S*, Liu W*. Increased serum chemerin concentrations in patients with polycystic ovary syndrome: Relationship between insulin resistance and ovarian volume.Clin Chim Acta. 2015 Oct 23;450:366-9. PMID: 26387454

Li S#, Liao Y#, Wang L, Huang R, Yue J, Xu H, Zhou H, Lou Z, Hu Y, Liu W*. Dysregulation of Hypothalamo-Pituitary-Adrenocortical Axis in Overweight Female Diabetic Subjects is Associated with Downregulation of Corticosteroid Receptors and 11β-HSD1 in the Brain. Horm Metab Res. 2016 Mar;48(3):178-184. doi: 10.1055/s-0035-1555902. PMID: 26212138

Li S#, Chu Q#, Ma J#, Sun Y, Tao T, Huang R, Liao Y, Yue J, Zheng J, Wang L, Xue X, Zhu M, Kang X, Yin H*, Liu W*. Discovery of novel lipid profiles in PCOS: Do insulin and androgen oppositely regulate bioactive lipid production? J Clin Endocrinol Metab. 2017 Mar 1;102(3):810-821. doi: 10.1210/jc.2016-2692.

Liao Y#, Huang R#, Sun Y, Yue J, Zheng J, Wang L, Tao T, Ma J, Li S*, Liu W*. An inverse association between serum soluble receptor of advanced glycation end products and hyperandrogenism and potential implication in polycystic ovary syndrome patients. Reprod Biol Endocrinol. 2017 Jan 26;15(1):9. doi: 10.1186/s12958-017-0227-8.

Deng Y#, Zhang Y#, Li S#, Zhou W, Ye L, Wang L, Tao T, Gu J, Yang Z, Zhao D, Gu W, Hong J, Ning G, Liu W*, Wang W*. Steroid hormone profiling in obese and nonobese women with polycystic ovary syndrome. Sci Rep. 2017 Oct 26;7(1):14156. doi: 10.1038/s41598-017-14534-2.

Huang R#, Xue X#, Li S#, Wang Y, Sun Y, Liu W1, Yin H*, Tao T*. Alterations of polyunsaturated fatty acid metabolism in ovarian tissues of polycystic ovary syndrome rats. J Cell Mol Med. 2018 Jul;22(7):3388-3396. doi: 10.1111/jcmm.13614. Epub 2018 Mar 30.

Liu Y#, Li S#, Tao T, Li X, Zhu Q, Liao Y, Ma J, Sun Y, Liu W*. Intrafollicular fibroblast growth factor 13 in polycystic ovary syndrome: relationship with androgen levels and oocyte developmental competence. J Ovarian Res. 2018 Sep 26;11(1):87. doi: 10.1186/s13048-018-0455-3.

Ma J#, Yue J#, Huang R, Liao Y, Li S*, Liu W*. Reversion of aging-related DHEAS decline in mouse plasma alleviates aging-related glucose tolerance impairment by potentiation of glucose-stimulated insulin secretion of acute phase. Biochem Biophys Res Commun. 2018 Jun 7;500(3):671-675. doi: 10.1016/j.bbrc.2018.04.134.

Wang Y, Huang R, Li X, Zhu Q, Liao Y, Tao T, Kang X, Liu W, Li S*, Sun Y*. High concentration of chemerin caused by ovarian hyperandrogenism may lead to poor IVF outcome in polycystic ovary syndrome: a pilot study. Gynecol Endocrinol. 2019 Jun 3:1-6. doi: 10.1080/09513590.2019.1622087.

Li S#, Qi J#, Tao Y, Zhu Q, Huang R, Liao Y, Yue J, Liu W, Zhao H, Yin H*, Sun Y*. Elevated Levels of Arachidonic Acid Metabolites in Follicular Fluid of PCOS Patients. Reproduction. 2020,159 159–169.  doi: 10.1530/REP-19-0136.

Jiang Y#, Qi J#, Xue X, Huang R, Zheng J, Liu W, Yin H*, Li S*. Ceramide subclasses identified as novel lipid biomarker elevated in women with polycystic ovary syndrome: a pilot study employing shotgun lipidomics. Gynecol Endocrinol. 2019 Dec 3:1-5. doi: 10.1080/09513590.2019.1698026.

Li X#, Zhang T#, Li S#, Deng Y, Wang L, Tao T, Wang S, Gu Y, Gu W, Hong J, Liu W*, Wang W*, Zhang Y*.Correlation between glucose metabolism and serum steroid hormones in patients with polycystic ovary syndrome. Clin Endocrinol (Oxf). 2020 Apr;92(4):350-357. doi: 10.1111/cen.14154. Epub 2020 Jan 29.

Wang H#, Li S#, Dai Q, Gonzalez A, Tran ON, Sun H, DeFronzo RA, Dean DD, Yeh CK, Chen XD*. Culture on a native bone marrow-derived extracellular matrix restores the pancreatic islet basement membrane, preserves islet function, and attenuates islet immunogenicity. FASEB J. 2020 Jun;34(6):8044-8056. doi: 10.1096/fj.201902893R. Epub 2020 Apr 19. PMID: 32307751; PMCID: PMC8034411.

Qi Y#, Liu W#, Wang X, Lu N, Yang M, Liu W, Ma J, Liu W, Zhang W*, Li S*. Adipose-derived mesenchymal stem cells from obese mice prevent body weight gain and hyperglycemia. Stem Cell Res Ther. 2021 May 6;12(1):277. doi: 10.1186/s13287-021-02357-y. PMID: 33957965.

Feng Y#, Qi J#, Xue X, Li X, Liao Y, Sun Y, Tao Y, Yin H, Liu W, Li S*, Huang R*. Follicular free fatty acid metabolic signatures and their effects on oocyte competence in non-obese PCOS patients. Reproduction. 2022 May 23;164(1):1-8. doi: 10.1530/REP-22-0023. PMID: 35521903.