RESEARCH INTEREST: Gynecologic tumor
Dr. Zhang, graduated from Shanghai Second Medical College (now Shanghai Jiaotong University School of Medicine), received a Doctor degree in Obstetrics and Gynecology, and engaged in Gynecology Oncologic clinical work for more than 20 years. Currently, her clinical work focuses on comprehensive diagnosis and treatment of gynecological tumors, and she is good at hysteroscopy and laparoscopic gynecological surgery. Her research focuses on developing new targeted therapies for gynecologic malignancies, with a specific interest in ovarian cancer. She presided eight projects, including four programs of the National Natural Science Foundation of China and four Provincial Natural Science programs, and published more than 20 SCI papers in English. She has received Shanghai “Phosphor” Scholar Award, Shanghai Jiaotong University “Morning Star” Award, and the title of "Research-oriented Doctor" of Shanghai Jiaotong University.
Zhang P. P., Su T., Zhang S. Comprehensive Analysis of Prognostic Value of MEX3A and Its Relationship with Immune Infiltrates in Ovarian Cancer. Journal of Immunology Research, v: 2021, 2021.
Su T., Zhang P. P., Zhao F. J., Zhang S. A novel immune-related prognostic signature in epithelial ovarian carcinoma. Aging-Us, v: 13, i: 7, p: 10289-10311, 2021.
Su T., Zhang P. P., Zhao F. J., Zhang S. Exosomal MicroRNAs Mediating Crosstalk Between Cancer Cells With Cancer-Associated Fibroblasts and Tumor-Associated Macrophages in the Tumor Microenvironment. Frontiers in Oncology, v: 11, 2021.
Yihan Bai, Kemin Yin, Tong Su, Fang Ji, Shu Zhang. CTHRC1 in Ovarian Cancer Promotes M2-Like Polarization of Tumor-Associated Macrophages via Regulation of the STAT6 Signaling Pathway. OncoTargets and Therapy 2020:13, 5743-5753.
Lu‑Ying Li, Ke‑Min Yin, Yi‑Han Bai, Zhi‑Gang Zhang, Wen Di, Shu Zhang. CTHRC1 promotes M2‑like macrophage recruitment and myometrial invasion in endometrial carcinoma by integrin‑Akt signaling pathway. Clinical & Experimental Metastasis (2019) 36:351–363.
Biying Guo, Huan Yan, Luying Li, Kemin Yin, Fang Ji and Shu Zhang*. Collagen triple helix repeat containing 1 (CTHRC1) activates Integrin β3/FAK signaling and promotes metastasis in ovarian cancer. Journal of Ovarian Research 2017,10:69.
Wen Yu Shao, Yong Liang Yang, Huan Yan, Qian Huang, Kai Jiang Liu & Shu Zhang. Phenethyl isothiocyanate suppresses the metastasis of ovarian cancer associated with the inhibition of CRM1-mediated nuclear export and mTOR-STAT3 pathway. CANCER BIOLOGY & THERAPY. 2017, 18, (1) 26–35.
Shu Zhang, Huan Yan, Wen-ting Ji. Uterine artery embolization combined with intra-arterial MTX infusion: its application in treatment of cervical pregnancy. Archives of Gynecology and Obstetrics.2016, 293(5):1043-1047.
Yan H, Guo BY, Zhang S*. Cancer-associated fibroblasts attenuate Cisplatin-induced apoptosis
in ovarian cancer cells by promoting STAT3 signaling. BiochemBiophys Res Commun. 2016; 470(4):947-954.
Luo-qiao Wang, Yue Zhang, Huan Yan, Kaijiang Liu, Shu Zhang*. MicroRNA-373 functions as
an oncogene and targets YOD1 gene in cervical cancer. BiochemBiophys Res Commun. 2015 Apr 10;459(3):515-20.
Yue Zhang，Fu-Jun Zhao，Li-Lan Chen，Luo-Qiao Wang，Kenneth P. Nephew，Ying-Li Wu，Shu Zhang*.MiR-373 targeting of the Rab22a oncogene suppresses tumor invasion and metastasis in ovarian cancer，Oncotarget，2014 Dec 15;5(23):12291-303.`
Chen L，Liu T，Zhou J，Wang Y，Wang X，Di W，Zhang S*. Citrate Synthase Expression Affects Tumor Phenotype and Drug Resistance in Human Ovarian Carcinoma，PLos One，2014，9（12）：1-19.
Jing Zhu，Shu Zhang*，LiyingGu，Wen Di. Epigenetic silencing of DKK2 and Wnt signal pathway components in human ovarian carcinoma，Carcinogenesis，2012，33（12）：2334-2343.
LI-CAI HE，FENG-HOU GAO，HAN-ZHANG XU，SHAN ZHAO，CHUN-MIN MA，JUNE LI，SHU ZHANG*，YING-LI WU.Ikaros inhibits proliferation and, through upregulation of Slug, increases metastatic ability of ovarian serous adenocarcinoma cells，Oncology Reports，2012，28：1399-1405.
Shu Zhang, Curt Balch, Michael W. Chan, Hung-Cheng Lai, Daniela Matei, Jeanne M. Schilder, Pearlly S. Yan, Tim H-M. Huang, and Kenneth P. Nephew. Identification and Characterization of Ovarian Cancer-Initiating Cells from Primary Human Tumors. Cancer Research. 2008, 68(11):4311-4320.