Ottawa-Shanghai Joint School of Medicine


ZHOU Shanghui

Associate Professor


Tel: 13818021014

Research Interests: 口腔黏膜癌变机理 Mechanism of oral mucosa carcinogenesis;

口腔颌面颈部肿瘤微创外科 Minimally invasive surgery for oral & maxillofacial- head & neck tumors


  • Dr. Shanghui Zhou obtained his M.D. and Ph.D. from Xiangya School of Medicine, Central South University and did his postdoc training in the Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, USA. He joined the Department of Oral & Maxillofacial - Head & Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine in 2009, and was appointed as attending in 2010 and associate professor in 2016.

  • Dr. Zhou is a consultant surgeon majoring in Oral and Maxillofacial Surgery and has 20 years of clinical experience. His research mainly focuses on the epidemiology of OSF malignant transformation and its underlying molecular mechanisms. He was awarded several grants including the National Natural Science Foundation of China (NSFC), Shanghai Pujiang Program, and  Natural Science Foundation of Shanghai, etc. He has published 27 scientific papers in international journals and 1 book on chewing betel nut and oral health. He is an external reviewer for multiple scientific journals including Oral Oncology, Cellular Oncology, etc.


  1. Zhang D#, Fu Y#,Tian G,Li J,Shang D, Zhou S*. UCHL1 promotes proliferation and metastasis in head and neck squamous cell carcinoma and could be a potential therapeutic target. Oral Surg Oral Med Oral Pathol Oral Radiol. 2022, 133(6):684-697.

  2. Zhou S, Zhu Y, Li Z, Zhu Y, He Z, Zhang C. Exosome-derived long non-coding RNA ADAMTS9-AS2 suppresses progression of oral submucous fibrosis via AKT signalling pathway. J Cell Mol Med. 2021, 25(4):2262-2273.

  3. Zhou S, Zhu Y, He Z, Zhang D, Guo F, Jian X, Zhang C. Long Non-Coding RNA Expression Profile Associated with Malignant Progression of Oral Submucous Fibrosis. J Oncol. 2019 Jul 29;2019:6835176. doi: 10.1155/2019/6835176.

  4. Zhou S, Zhu Y, Mashrah M, Zhang X, He Z, Yao Z, Zhang C, Guo F, Hu Y, Zhang C. Expression pattern of DKK3, dickkopf WNT signaling pathway inhibitor 3, in the malignant progression of oral submucous fibrosis. Oncol Rep, 2017, 37(2):979-985.

  5. Mashrah M, Zhou SH*, Abdelrehem A, Ma C, Xu L, He Y, Zhang C*. Oropharyngeal reconstruction with a pedicled submandibular gland flap. Br J Oral Maxillofac Surg, 2016, 54(4):388-93.

  6. Zhou S, Zhang C, Li D. Approaches of Robot-assisted Neck Dissection for Head and Neck Cancer: a Review. Oral Surg Oral Med Oral Pathol Oral Radiol, 2016, 121(4):353-9.

  7. Zhou S, Chen L, Mashrah M, Zhu Y, Liu J, Yang X, He Z, Wang L, Xiang T, Yao Z, Guo F, Yang W, Zhang C. Deregulation of secreted frizzled-related proteins is associated with aberrant β-catenin activation in the carcinogenesis of oral submucous fibrosis. Onco Targets Ther, 2015, 8(10): 2923-2931.

  8. Zhou S, Chen L, Mashrah M, Zhu Y, He Z, Hu Y, Xiang T, Yao Z, Guo F, Zhang C. Expression and promoter methylation of Wnt inhibitory factor-1 in the carcinogenesis of oral submucous fibrosis. Oncol Rep, 2015, 34(9): 2636-2642.

  9. Zhou SH, Yang WJ, Liu SW, Li J, Zhang CY, Zhu Y, Zhang CP. Gene expression profiling of craniofacial fibrous dysplasia reveals ADAMTS2 overexpression as a potential marker. Int J Clin Exp Pathol, 2014, 7(12): 8532-8541.

  10. Zhou S *, Qu X, Yu Z, Zhong L, Ruan M, Ma C, Wang M, Zhang C, Jian X. Survivin as a potential early marker in the carcinogenesis of oral submucous fibrosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2010, 109(4):575-581.

  11. Zhou S, Li L, Jian X, Ou X, Jiang H, Yao Z, Xu C, Peng J. The phosphorylation of survivin Thr34 by p34cdc2 in carcinogenesis of oral submucous fibrosis. Oncol Rep, 2008,20(5):1085- 1091.

  12. 1Zhou S, Guo F, Li L, Zhou Y, Lei Y, Hu Y, Su H, Chen X, Yin P, Jian X. Multiple logistic regression analysis of risk factors for carcinogenesis of oral submucous fibrosis in mainland China. Int J Oral Maxillofac Surg, 2008, 37(12):1094-1098.

  13. Li L#, Zhou S#, Chen X, Guo L, Li Z, Hu D, Luo X, Ma X, Tang M, Yi W, Tsao SW, Cao Y*. The activation of p53 mediated by Epstein-Barr virus latent membrane protein 1 in SV40 large T-antigen transformed cells. FEBS Lett, 2008, 582(5):755-762.