Research Interests

• Our research areas include oral potential malignant diseases and oral infectious diseases. We are particularly interested in the new synergistic methods of photodynamic therapy and chemopreventive drugs for oral leukoplakia.

Biography

• Dr. Lan Wu, chief doctor of the department of Oral Medicine, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. She’s the Standing Committee member of Chinese society of Oral Medicine, Chinese Stomatological Association, and the vice chairman of Shanghai society of Oral Medicine, Shanghai Stomatological Association.

Teaching Responsibilities

1. Course Instructor, Oral Mucosal Diseases for Dental Students

2. Course Instructor, Case Study Based Learning (Oral lesions) for Ottawa-Shanghai Joint School of Medicine

Research Interests

• Our research areas include oral potential malignant diseases and oral infectious diseases. We are particularly interested in the new synergistic methods of photodynamic therapy and chemopreventive drugs for oral leukoplakia.

Grants

1. Cross disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai JiaoTong university School of Medicine, “Modern network pharmacology research and Prescription Optimization of compound Gynostemma pentaphyllum in the treatment of oral leukoplakia,” Principal Investigator,￥200,000, 09/01/2021-08/31/2024

2. Shanghai Municipal Health Commission, Shanghai Administration of traditional Chinese medicine, subproject of the three-year action plan of Shanghai to further accelerate the inheritance, innovation and development of traditional Chinese medicine (2021-2023): “establishment of a collaborative standardized diagnosis and treatment system of traditional Chinese and Western medicine for potential malignant oral diseases,” Principal Investigator,￥1000,000, 12/01/2021-12/31/2023

3. Shanghai Municipal Science and Technology Commission, “preclinical study of compound Gynostemma pentaphyllum capsule, a hospital preparation for the treatment of potential oral malignant diseases,” Principal Investigator,￥400,000, 07/01/2021-06/30/2023

4. Clinical Research Plan of SHDC, “Evaluator blind and randomized controlled study of photodynamic therapy for oral leukoplakia under the guidance of precise screening technology,” Principal Investigator: Guoyao Tang; Project Leader: Lan Wu; ￥800,000, 12/01/2016-12/31/2019

5. National Natural Science Foundation of China, “Screening of lncRNAs related to DNA damage signaling pathway and Research on its regulation mechanism during Oral Leukoplakia Carcinogenesis,” Principal Investigator,￥230,000, 01/01/2015-12/31/2017

Selected Publications

1. Yao Y, Wang Y, Li C, Wu L, Tang G. Management of oral leukoplakia by ablative fractional laser-assisted photodynamic therapy: a 3-year retrospective study of 48 patients. Laser Surg Med. 2022, Mar 7 online. https://doi.org/10.1002/lsm.23534.

2. Liu W, Zhou Z, Zhu L, Li H, Wu L. Chemopreventive efficacy of salvianolic acid B phospholipid complex loaded nanoparticles against experimental oral carcinogenesis: implication of sustained drug release. Ann Transl Med. 2022; 10(5): 244.

3. Liu W, Zhu L, Xu L, Wu L. Exophytic verrucous hyperplasia as a clinical terminology includes verrucous hyperplasia with or without epithelial dysplasia in histology. Oral Oncol. 2021; 122: 105571.

4. Yao Y, Shi L, Wang Y, Shen X, Ye S, Tang G, Wu L. Ablative fractional laser-assisted photodynamic therapy vs. ablative fractional laser for oral leukoplakia treatment: A randomized, controlled pilot study. Photodiagnosis Photodyn Ther. 2021; 36: 102523.

5. Zhou Y, Yao Y, Liu W, Shen X, Shi L, Wu L. MicroRNA-134 inhibits tumor stem cell migration and invasion in oral squamous cell carcinomas via downregulation of PI3K-Akt signaling pathway by inhibiting LAMC2 expression. Cancer Biomark. 2020; 29(1):51-67.

6. Yao Y, Shi L, Zhang C, Sun H, Wu L. Application of fungal fluorescent staining in oral candidiasis: diagnostic analysis of 228 specimens, BMC microbiology, BMC Microbiol. 2019; 19(1): 96.

7. Li H, Shi L, Wei J, Zhang C, Zhou Z, Wu L, Liu W. Cellular uptake and anticancer activity of salvianolic acid Bphospholipid complex loaded nanoparticles in head and neck cancer and precancer cells. Colloids Surf B Biointerfaces. 2016, 147: 65-72.