Ottawa-Shanghai Joint School of Medicine


ZHU  Yaqin



Telephone: 86-21-53315542

Research area: Regeneration and repair of dentin and periodontal tissue; Oral microbiome and systemic diseases


  • Prof. Yaqin Zhu, the Director of Department of General Dentistry, Shanghai Ninth People’s Hospital affiliated School of Medicine, Shanghai Jiao Tong University; Director of General Dentistry & Dental Emergency,College of Stomatology Shanghai Jiao Tong University. She is also the Chairman of Chinese Society of Stomatological Emergency, the Vice-Chairman of Chinese Society of General Dentistry, the member of the Chinese Oral Medicine Education Society, fellow of the International College of Dentists, member of the editorial board of Shanghai Journal of Stomatology, Journal of Oral Materials and Instruments, International Journal of Stomatology, and Chinese Journal of Practical Stomatology. From 2005 to 2006, she was a visiting scholar at Faculty of Dentistry, University of Michigan. She has been engaged in clinical practice, teaching and research in dentistry areas for more than 30 years. She is good at the comprehensive diagnosis and treatment of dental diseases, cosmetic restoration, endodontic therapy & post-endo restoration, and comprehensive diagnosis and treatment of adult tooth trauma. She is responsible for the courses of“Oral Emergency Medicine” for students of College of Stomatology Shanghai Jiao Tong University , the course of “Stomatology”for students of School of Medicine Shanghai Jiao Tong University, and the Oral Health part of the Unit II course of Ottawa-- Shanghai Joint School of Medicine. Her research interests include oral microbiome and systemic diseases (e.g., hypertension, neurodegenerative changes, etc.), regeneration and repair of dentin and periodontal tissue. He has published more than 160 papers, including 36 SCI papers, 19 monographs, and 24 scientific research projects such as the National Natural Science Foundation of China and the Basic Key Projects of Shanghai Municipal Science and Technology Commission. As a major participant, she won the second prize of Shanghai Science and Technology Progress Award, the third prize of the State Education Commission's Scientific and Technological Achievement Promotion Award.


  • Long Jiang, Ya-Qin Zhu, Rong Du, et al. The Expression and Role of Stromal Cell–derived Factor-1α–CXCR4 Axis in Human Dental Pulp.J Endodon 2008;34(8):939-944

  • Ya Yang,Lu-dong Zhang,jian-Ping Ge,Ya-qin Zhu.Prevalence of 3-root first permanent molars among a Shanghai Chinese population. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology.2010;110(5): e101

  • Ya Yang,Ya-qin Zhu,Long Jiang,Li-fen Li.Thalidomide induces apoptosis in human oral squamous cell carcinoma cell line with altered expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).Oral Oncology. 2011; 47:927-928

  • Ya Yang,Jian-ping Ge,Long Jiang,Li-feng Li,Ya-qin Zhu.Modulation of growth and angiogenic potential of oral squamous carcinoma cells in vitrousing salvinolic acid B.BMC complementary and Alternative Medicine.2011;11:54

  • Li-fen Li,Ya-qin Zhu,Long Jiang,Wei-wei Peng,Helena H. Ritchie.Hypoxia promote mineralization of human dental pulp cells. J Endodon 2011;37(6):799-802

  • Wei-wei Peng, Wei-ning Liu, Wan-yin Zhai,Long Jiang,Li-fen Li, Jiang Chang,Ya-qin Zhu.Effect of tricalcium silicate on the proliferation and odontogenic differentiation of human dental pulp cells. J Endodon 2011;37(9):1240-1246

  • Xu-na Tang 1, Ya-qin Zhu 1, Cynthia L. Marcelo, Helena H. Ritchie. Expression of mineralized tissue associated proteins: Dentin sialoprotein and phosphophoryn in rodent hair follicles.Journal of Dermatological Science 2011;64:92-98

  • Long Jiang, Wei-Wei Peng, Li-Fen Li, Ya Yang,Ya-Qin Zhu.Proliferation and Multilineage Potential of CXCR4-positive Human Dental Pulp Cells In Vitro. J Endodon 2012;38(5):642-647

  • Long Jiang, Wei-Wei Peng, Li-Fen Li, Ya Yang,Ya-Qin Zhu.Isolation and Identification of CXCR4-positive Cells from Human Dental Pulp Cells. J Endodon 2012;38(6):791-795

  • Li-Fen Li, Ya-Qin Zhu. Long Jiang, Wei-Wei Peng. Increased autophagic activity in senescent human dental pulp cells. International Endodontic Journal. 2012;45(12):1074-1079

  • Jiang Tao, Fang Ji, Baojun Liu, Feng Wang, Feng Dong, Yaqin Zhu.Improvement of deficits by transplantation of lentiviral vector-modified human amniotic mesenchymal cells after cerebral ischemia in rats. Brain Research 1 4 4 8 ( 2 0 1 2 ) 1 – 1 0

  • Jiang Tao, Fang Ji, Feng Wang, Baojun Liu, Yaqin Zhu.Neuroprotective effects of progranulin in ischemic mice. Brain Research 1 4 3 6 ( 2 0 1 2 ) 1 3 0 – 1 3 6

  • Rong Du, Tiantian Wu, Wenjuan Liu, Lifen Li, LongJiang, Weiwei Peng, Jiang Chang, Yaqin Zhu. Role of the Extracellular Signal-regulated kinase 1/2 pathway in Driving Tricalcium Silicate-induced Proliferation and Biomineralization of Human Dental Pulp Cells in Vitro. J Endodon 2013;39(8):1023-1029

  • Tiantian Wu, Lifen Li, Rong Du,Long Jiang, Yaqin Zhu. Hydrogen Peroxide Induces Apoptosis in Human Dental pulp Cells via Caspase-9 Dependent Pathway. J Endodon 2013;39(9):1151-1155

  • Ya Yang, Yuexiu Li, long Jiang, Zuojun Zhou,Yaqin Zhu. Progress risk assessment of oral premalignant lesion with saliva miRNA analysis. BMC CANCER,2013,13:129

  • Sheng Ding, Ruiqing Zhou and Yaqin Zhu. Crystallization and preliminary crystallographic analysis of the chimeric protein LKB1–14-3-3ζ. Acta Cryst. (F), 2013; 69; 1371–1373

  • Long jiang,Wei-wei Peng, Li-fen Li,Rong Du,Tian-tian Wu, jun-jun Zhao,Ya Yang, Dong-li Qu,Ya-qin Zhu. Effects of Deferoxamine on the Repair Ability of Dental Pulp Cells In Vitro. J Endodon 2014;40(8):1100-1104

  • Ya Yang, NL Rhodus,FG Ondrey,BRK Wuertz,Xiaobing Chen,Yaqin Zhu. Quantitative Proteomic Analysis of Oral Brush Biopsies Identifies Secretory Leukocyte Protease Inhibitor as a Promising,Mechanism-Based Oral Cancer Biomarker.PLOS 2014;9(4):e95389

  • Jiang Tao,Suxiong Tao,Junli Han,Zhujun Zhou,Xiaoping Zhang,Haining Wang,Rongji Chen,Fang ji,Yaqin Zhu. RECQL1 Plays an Important Role in the Development of Tongue Squamous Cell Carcinoma.Cell Physiol Biochem 2014;33:1579-1590

  • Yanyan Han,Sisu Mo,long jiang,Yaqin Zhu. Effects of antioxidants on the microleakage of composite resin restorations after external tooth bleaching.European Journal of Dentistry 2014;8(2):147-153

  • Ding, S., R. Zhou, and Y. Zhu, Structure of the 14-3-3 zeta-LKB1 fusion protein provides insight into a novel ligand-binding mode of 14-3-3. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2015. 71: p. 1114-1119.

  • Xuan Wang, Tian Tian Wu,Long Jiang,Du Rong,Ya Qin Zhu. Deferoxamine-induced migration and odontoblast differentiation via ROS-dependent autophagy in dental pulp stem cells. Cell Physiol Biochem 2017;43:2535-2547(IF 5.500)

  • ZHU yaqin, SONG Ryan M,Ritchie Helena H. Differential expression between DSP-only and DSP-PP523 transcripts in rat molar tooth. Archives of Oral Biology,2017,B2:33-37

  • Tiantian WU,Chen XU,Rong DU,Yang WEN,Jiang Chang ,Zhiguang HUAN, Yaqin ZHU*.Effects of silicate-based composite material on the proliferation and mineralization behaviors of human dental pulp cell:An in vitro Assessment.Dental Materials Journal 2018:37(6):889-896

  • Lou, Q., Y. Zhu, and X. Wang, Fourteen Years After Delayed Replantation of an Avulsed Permanent Tooth: Clinical Features and Outcomes. JOURNAL OF CRANIOFACIAL SURGERY, 2019. 30(8): p. E692-E694.

  • Zhao, J.-j., L. Jiang, Y.-q. Zhu, and X.-p. Feng, Effect of Lactobacillus acidophilus and Porphyromonas gingivalis on proliferation and apoptosis of gingival epithelial cells. ADVANCES IN MEDICAL SCIENCES, 2019. 64(1): p. 54-57.

  • Li, J., T. Wu, W. Peng, and Y. Zhu, Effects of resveratrol on cariogenic virulence properties of Streptococcus mutans. BMC MICROBIOLOGY, 2020. 20(1).

  • Cheng, F. and Y. Zhu, The efficacy of different instruments combined with Nd: YAP in endodontic retreatment. ANNALS OF TRANSLATIONAL MEDICINE, 2021. 9(14).

  • Du, R., J. Zhao, Y. Wen, Y. Zhu, and L. Jiang, Deferoxamine enhances the migration of dental pulp cells via hypoxia-inducible factor 1 alpha. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2021. 13(5): p. 4780-4787.

  • Tao, J., Y. Lin, L. Jiang, Z. Zhou, J. Zhao, D. Qu, W. Li, and Y. Zhu, Psychological Impact of the COVID-19 Pandemic on Emergency Dental Care Providers on the Front Lines in China. INTERNATIONAL DENTAL JOURNAL, 2021. 71(3): p. 197-205..Zhou, M., H. Zhang, H. Camhi, F. Seymen, M. Koruyucu, Y. Kasimoglu, J.-W. Kim, H. Kim-Berman, N.M.R. Yuson, P.J. Benke, Y. Wu, F. Wang, Y. Zhu, J.P. Simmer, and J.C.C. Hu, Analyses of oligodontia phenotypes and genetic etiologies. INTERNATIONAL JOURNAL OF ORAL SCIENCE, 2021. 13(1).

  • Zhou, M., H. Zhang, H. Camhi, F. Seymen, M. Koruyucu, Y. Kasimoglu, J.-W. Kim, H. Kim-Berman, N.M.R. Yuson, P.J. Benke, Y. Wu, F. Wang, Y. Zhu, J.P. Simmer, and J.C.C. Hu, Analyses of oligodontia phenotypes and genetic etiologies (vol 13, 32, 2021). INTERNATIONAL JOURNAL OF ORAL SCIENCE, 2021. 13(1).

  • 33.Jiang, L., T. Krongbaramee, X. Lin, M. Zhu, Y. Zhu, and L. Hong, microRNA-126 inhibits vascular cell adhesion molecule-1 and interleukin-1beta in human dental pulp cells. JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2022. 36(5).

  • 34.Li, L., Y. Wen, L. Jiang, and Y.-Q. Zhu, Endoplasmic reticulum stress response mediated by the PERK-eIF2 alpha-ATF4 pathway is involved in odontoblastic differentiation of human dental pulp cells. ARCHIVES OF ORAL BIOLOGY, 2022. 133.

  • 35.Peng, W., Z. Huan, G. Pei, J. Li, Y. Cao, L. Jiang, and Y. Zhu, Silicate bioceramics elicit proliferation and odonto-genic differentiation of human dental pulp cells. DENTAL MATERIALS JOURNAL, 2022. 41(1): p. 27-36.

  • Lin X, Wang H, Wu T, Zhu Y, Jiang L. Exosomes derived from stem cells from apical papilla promote angiogenesis via miR-126 under hypoxia [published online ahead of print, 2022 Jun 20]. Oral Dis. 2022;10.1111