Ottawa-Shanghai Joint School of Medicine
Ottawa-Shanghai Joint School of Medicine

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GE Heng

Consultant doctor, Associate professor

Email: dr.geheng@foxmail.com

Tel: 86 13816991370

Research Fields: clinical and fundamental research on atherosclerosis

Biography

Dr. Ge Heng, graduated from Shanghai Jiao Tong University School of Medicine in 2006 with a medical doctor's degree. Since 2006, he has been working in Renji Hospital affiliated to Shanghai Jiao Tong University School of Medicine. Now he is the chief physician of Cardiovascular Medicine, associate professor and master tutor of Shanghai Jiao Tong University School of Medicine. From September 2021, he has been serving as the vice president of the Second People's Hospital of Kashgar, Xinjiang in a 1.5-year project to support Xinjiang district. From September 2010 to September 2011, he was a visiting scholar at the Cardiovascular Center of the University Hospital of Zurich with a scholarship from the Swiss Federal Government. He received training in interventional cardiac surgery and cardiac magnetic resonance examination during the staying. From February to May 2014, he studied transcatheter aortic valve replacement in the Cardiovascular and Pulmonary Hospital of the Second University of Lyon, France. And from May to September, 2018, he made studies about cardiac magnetic resonance imaging in the National Institution of health, USA.  He is an interventional cardiologist of coronary heart disease, and structural heart disease as well as critical cardiovascular disease and cardiac magnetic resonance imaging. In research, he has presided over 2 National Natural Science Foundation of China projects and 6 provincial and ministerial level projects. He has published 20 SCI papers as the first and corresponding author, with the highest impact factor of 29. He also published one book. He is the member of several academic organizations such as the International Society of Cardiac Magnetic Resonance, China branch, Shanghai Medical Association, cardiovascular disease branch He is also an invited editorial board member of the Chinese Journal of Medical Imaging and a reviewer of PLOS One. He has won the third prize of the "Teaching and Educating Award" of Shanghai Jiao Tong University, and the "President's Special Award" of Shanghai Jiao Tong University.hysician Award" of the Great Wall International Conference on Cardiology (GW-ICC), the "Young Investigator Award" of the Asia Pacific Association of Echocardiography (AAE), and the second prize of the 3rd Shanghai Ultrasound Skills Competition. He participated in the publication of 21 SCI papers. As a co-author, he won the second prize of the Science and Technology Progress Award from Ministry of Education and the second prize of the Chinese Medical Science and Technology Award.

Publications

  1. 葛恒， 王长谦. 《PPAR配体作用机制及新配体筛选研究进展》中国药学杂志 2004年39卷3期： 170－172

  2. 葛恒， 王长谦.  《PPAR及其配体药物在预防冠脉再狭窄中的潜在作用》上海第二医科大学学报 2005年25卷1期：82－84

  3. 葛恒， 张俊峰， 王长谦 等. 《白藜芦醇对PPARγ激动作用的研究》 中国药学杂志 2005年40卷12期：905－908

  4. 葛恒， 张俊峰， 郭炳诗  等.《胰岛素对PPARγ配体结合转录活性的影响》 上海第二医科大学学报 2005年25卷9期：894－896

  5. 葛恒， 张俊峰， 王长谦 等.《PPAR γ激动剂筛选模型的建立及其应用》上海交通大学医学院学报. 2006年26卷3期：221－224

  6. 葛恒， 张清， 何奔 等. 《双胞胎同患急性心肌梗死一例》 中华心血管病杂志 2006年34卷2期：177－178

  7. 葛恒， 张俊峰， 郭炳诗 等《白藜芦醇抑制巨噬细胞细胞外基质金属蛋白酶诱导物的表达》 药学学报 2006年41卷7期：625－630

  8. GE H，Zhang J，Guo BS, et al. Resveratrol inhibits macrophage expression of EMMPRIN by activating PPARgamma. Vascular Pharmacology 2007；46(2):114-21

  9. Zhang J，Ge H, Wang C, et al. Inhibitory effect of PPAR on the expression of EMMPRIN in macrophages and foam cells. International Journal of Cardiology 2007 ;117(3):373-80 (共同第一作者)

  10. Ge H Inhibitory Effects of Resveratrol on CD40 Expression of Macrophages （摘要）The Society for cardiovascular angiography and interventions 2007年会及会刊收录

  11. 王长谦， 葛恒， 王彬尧. 《肥厚型心肌病的临床进展》 新医学2004年35卷 9期：573－574

  12. 张俊峰，葛恒，王长谦 等. 《高胰岛素状态下巨噬细胞PPARγ抗炎活性的变化》 心脏杂志 2006年18卷1期14－17

  13. 王彬尧，葛恒 《冠心病介入治疗及循证医学评价》 新医学2006年37卷6期：410－411

  14. 张俊峰，葛恒，王长谦 等. 《PPARs配体对巨噬、泡沫细胞细胞外基质金属蛋白酶诱导因子(EMMPRIN)表达的影响》. 中国病理生理杂志 2006年22卷8期：1519－1523

  15. 张俊峰，葛恒，王长谦 等. 《PPARα配体对泡沫细胞炎性介质分泌的影响》. 心脏杂志 2006年18卷3期：262－264

  16. 张俊峰，葛恒，王长谦 等 《细胞外基质金属蛋白酶诱导因子在巨噬、泡沫细胞的表达变化》 上海第二医科大学学报,2006年 26卷3期：225－228

  17. 张俊峰，葛恒，王长谦 等. PPARγ配体抑制巨噬/泡沫细胞炎性介质的分泌. 中国动脉硬化杂志. 2006年14卷4期：281－285

  18. 张清，葛恒，韩志华 等. 《药物洗脱支架和金属裸支架治疗冠状动脉小血管病变的疗效》 福建医科大学学报 2007年41卷3期：231－233

  19. 何清，王长谦，葛恒 等. 《特异性抑制单核细胞中EMMPRIN基因表达的SiRNA的筛选和鉴定》上海交通大学学报 医学版2007年27卷6期：681－684

  20. 袁伟，何奔，葛恒。《细胞外基质金属蛋白酶诱导因子在动脉粥样硬化发展进程中的相关研究进展》　中国动脉硬化杂志　2008年16卷7期 582－584

  21. Jiang M, He B, Zhang Q, Ge H, et al. Randomized controlled trials on the therapeutic effects of adult progenitor cells for myocardial infarction: meta-analysis. Expert Opin Biol Ther. 2010;10(5):667-80.

  22. Zhou L, Shen LH, Hu LH, Ge H, Retinoid X receptor agonists inhibit phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 cells into macrophages. Mol Cell Biochem. 2010 ;335(1-2):283-9

  23. Ge H，Zhang Q，Wang BY, He B. Therapeutic effect of statin on aortic stenosis: A review with Meta-analysis. Journal of Clinical Pharmacy and Therapeutics 2010 35，385-393

  24. Ge H, Zhang Q, He B, et al. Efficacy and safety of drug-eluting stent implantation for the treatment of in-stent restenosis occurring within bare-metal stent and drug-eluting stent. J Zhejiang Univ-Sci B (Biomed & Biotechnol) 2010 11(8):553-560

  25. Yuan W, Ge H, He B, et al. Pro-inflammatory activities induced by CyPA–EMMPRIN interaction in monocytes. Atherosclerosis 2010;213(2):415-21 （共同第一作者）

  26. Stähli BE, Bünzli R，Ge H, et al. Transcatheter aortic valve implantation (TAVI) outcome according to standardized endpoint definitions by the valve academic research consortium (VARC). J Invasive Cardiol. 2011 ;23(8):307-12

  27. Zhang TT, Ge H, Zhang JF. Functions of cyclophilin A in atherosclerosis. Exp Clin Cardiol. 2013; 18(2):e118-24

  28. 28.Lyu T, Zhao Y, Zhang T, Zhou W, Yang F, Ge H, Ding S, Pu J, He B. Natriuretic peptides as an adjunctive treatment for acute myocardial infarction: insights from the meta-analysis of 1,389 patients from 20 trials. Int Heart J. 2014; 55(1):8-16

  29. Ding S, Xu L, Yang F, Kong L, Zhao Y, Gao L, Wang W, Xu R, Ge H, Jiang M, Pu J, He B, Association between tissue characteristics of coronary plaque and distal embolization after coronary intervention in acute coronary syndrome patients: insights from a meta-analysis of virtual histology-intravascular ultrasound studies. PLoS One. 2014 ;9(11):e106583

  30. Ge H, Yuan w, Ding S, Pu J, He B. Functional relevance of protein glycosylation to the pro-inflammatory effects of Extracellular Matrix Metalloproteinase Inducer（EMMPRIN）on monocytes/macrophages. Plos One 2015 ;10(2):e0117463

  31. Ding S, Zhao H, Qiao ZQ, Yang F, Wang W, Gao LC, Kong LC, Xu RD, Ge H, Shen XD, Pu J, He B. Early resolution of ST-segment elevation after reperfusion therapy for acute myocardial infarction: Its relation to echocardiography-determined left ventricular global and regional function and deformation. J Electrocardiol. 2015 ;48(2):241-8

  32. He B, Ge H, Yang F, Sun Y, Li Z, Jiang M, Fan Y, Pu J, Shen X. A Novel Method in the Stratification of Post-Myocardial-Infarction Patients Based on Pathophysiology. PLoS One. 2015;10(6):e0130158 （共同第一作者）

  33. Ding S, Li Z, Ge H, Qiao ZQ, Chen YL, Andong AL, Yang F, Kong LC, Jiang M, He B, Pu J. Impact of Early ST-Segment Changes on Cardiac Magnetic Resonance-Verified Intramyocardial Haemorrhage and Microvascular Obstruction in ST-Elevation Myocardial Infarction Patients. Medicine (Baltimore). 2015;94(35):e1438

  34. Zheng Y, Sun JP, Shen X, Qiao Z, Ge H, Li Z, He B, Yu CM. Subepicardial Aneurysm That Was Diagnosed by Cardiac Imaging and Underwent Successful Surgery. Circulation. 2015;132(12):e149-51

  35. Ge H, Ding S, An D, Li Z, Ding H, Yang F, Kong L, Xu J, Pu J, He B. Frame counting improves the assessment of post-reperfusion microvascular patency by TIMI myocardial perfusion grade: Evidence from cardiac magnetic resonance imaging. Int J Cardiol. 2016 ;203:360-6

  36. He B, Ding S, Qiao Z, Gao L, Wang W, Ge H, Shen X, Pu J. Influence of microvascular dysfunction on regional myocardial deformation post-acute myocardial infarction: insights from a novel angiographic index for assessing myocardial tissue-level reperfusion. Int J Cardiovasc Imaging. 2016 32(5):711-9

  37. Zhao H, Lee AP, Li Z, Qiao Z, Fan Y, An D, Xu J, Pu J, Shen X, Ge H, He B. Impact of Intramyocardial Hemorrhage and Microvascular Obstruction on Cardiac Mechanics in Reperfusion Injury: A Speckle-Tracking Echocardiographic Study. J Am Soc Echocardiogr. 2016 (10):973-982（共同通讯作者）

  38. Pu J, Ding S, Ge H, Han Y, Guo J, Lin R, Su X, Zhang H, Chen L, He B; EARLY-MYO Investigators. Efficacy and Safety of a Pharmaco-Invasive Strategy With Half-Dose Alteplase Versus Primary Angioplasty in ST-Segment-Elevation Myocardial Infarction: EARLY-MYO Trial (Early Routine Catheterization After Alteplase Fibrinolysis Versus Primary PCI in Acute ST-Segment-Elevation Myocardial Infarction). Circulation. 2017;136(16):1462-1473.

  39. Sheng X, Ding S, Ge H, Sun Y, Kong L, He J, Pu J, He B. Intracoronary infusion of alprostadil and nitroglycerin with targeted perfusion microcatheter in STEMI patients with coronary slow flow phenomenon. Int J Cardiol. 2018;265:6-11.

  40. 孔令璁;安东敖蕾;葛恒;许建荣;何奔;;使用心脏磁共振复查Watchman左心耳封堵器置入术后患者1例[J];中国介入心脏病学杂志;2018年03期，179-180页

  41. Leng S, Ge H, He J, Kong L, Yang Y, Yan F, Xiu J, Shan P, Zhao S, Tan RS, Zhao X, Koh AS, Allen JC, Hausenloy DJ, Mintz GS, Zhong L, Pu J. Long-term Prognostic Value of Cardiac MRI Left Atrial Strain in ST-Segment Elevation Myocardial Infarction. Radiology. 2020;296(2):299-309 (共同第一作者) JCR Q1

  42. He J, Kong LC, Zeng JT, Shi BZ, An DAL, Chen BH, Ding S, Li Z, Yang F, Yang YN, Yan FH, Xiu JC, Wang HW. Xu JR. Ge H, Pu J. Comparison of direct stenting with conventional strategy on myocardial impairments in ST-segment elevation myocardial infarction: a cardiac magnetic resonance imaging study.  Int J Cardiovasc Imaging. 2020;36(6):1167-1175.（通讯作者）JCR Q3

  43. He J, Ge H, Dong JX, Zhang W, Kong LC, Qiao ZQ, Zheng Y, Ding S, Wan F, Shen L, Wang W, Gu ZC, Yang F, Li Z, Pu J. Rationale and design of a prospective multi-center randomized trial of EARLY treatment by rivaroxaban versus warfarin in ST-segment elevation MYOcardial infarction with Left Ventricular Thrombus (EARLY-MYO-LVT trial). Annals of Translational Medicine 2020,8(6):392-40 (通讯作者) JCR Q3

  44. Sun JT, Chen Z, Nie P, Ge H, Shen L, Yang F, Qu XL, Ying XY, Zhou Y, Wang W, Zhang M, Pu J. Lipid Profile Features and Their Associations With Disease Severity and Mortality in Patients With COVID-19. Front Cardiovasc Med. 2020;7:584987.

  45. Gu ZC, Qiao ZQ, Hao ZY, Li Z, Jiang LS, Ge H, He B, Pu J. Initial anticoagulation experience with standard-dose rivaroxaban after Watchman left atrial appendage occlusion. Annals of Translational Medicine.2020,8(4):105-110 (通讯作者) JCR Q3

  46. Gu ZC, Zhang C, Kong LC, Shen L, Li Z, Ge H, Lin HW, Pu J. Incidence of myocardial injury in coronavirus disease 2019 (COVID-19): a pooled analysis of 7,679 patients from 53 studies. Cardiovasc Diagn Ther. 2020;10(4):667-677.

  47. Sheng X, Qiao Z, Ge H, Sun J, He J, Li Z, Ding S, Pu J. Novel application of quantitative flow ratio for predicting microvascular dysfunction after ST-segment-elevation myocardial infarction. Catheter Cardiovasc Interv. 2020 ;95 Suppl 1:624-632.

  48. Lai W, Jie H, Jian-Xun D, Ling-Cong K, Jun-Tong Z, Bo-Zhong S, Dong-Ao-Lei A, Bing-Hua C, Song D, Zheng L, Fan Y, Yi-Ning Y, Fu-Hua Y, Jian-Cheng X, Hu-Wen W, Jian-Rong X, Heng G, Jun P. Impact of Concomitant Impairments of the Left and Right Ventricular Myocardial Strain on the Prognoses of Patients With ST-Elevation Myocardial Infarction. Front Cardiovasc Med. 2021;8:659364. (通讯作者) JCR Q2

  49. Shi FH, Li H, Kong LC, Shen L, Jiang YH, Gu ZC, Ge H. Sulfonylureas Use Is Not Associated With Increased Infarct Size in Patients With Type 2 Diabetes and ST-Segment Elevation Myocardial Infarction. Front Cardiovasc Med. 2021;8:658059. (通讯作者) JCR Q2

  50. Zhong FY, Zhao YC, Zhao CX, Gu ZC, Lu XY, Jiang WL, Gao LC, Li WL, Qin ZH, Ge H, Pu J. The Role of CD147 in Pathological Cardiac Hypertrophy Is Regulated by Glycosylation. Oxid Med Cell Longev. 2022;2022:6603296. IF=6.8 （通讯作者）JCR Q2

  51. Ge H. Is diastolic dysfunction a new windsock in the risk stratification of patients with coronary heart disease? Int J Cardiol. 2022 ;346:103-104.. (第一和通讯作者) JCR Q2

  52. Zhao Y, Lu X, Wan F, Gao L, Lin N, He J, Wei L, Dong J, Qin Z, Zhong F, Qiao Z, Wang W, Ge H, Ding S, Yang Y, Xiu J, Shan P, Yan F, Zhao S, Ji Y, Pu J. Disruption of Circadian Rhythms by Shift Work Exacerbates Reperfusion Injury in Myocardial Infarction. J Am Coll Cardiol. 2022;79(21):2097-2115.

  53. Shi FH, Li H, Shen L, Xu L, Ge H, Gu ZC, Lin HW, Pu J. Beneficial Effect of Sodium-Glucose Co-transporter 2 Inhibitors on Left Ventricular Function. J Clin Endocrinol Metab. 2022;107(4):1191-1203.

  54. Shen L, Qiu L, Liu D, Wang L, Huang H, Ge H, Xiao Y, Liu Y, Jin J, Liu X, Wang DW, Peterson ED, He B, Zhou N. The Association of Low Molecular Weight Heparin Use and In-hospital Mortality Among Patients Hospitalized with COVID-19. Cardiovasc Drugs Ther. 2022 ;36(1):113-120.

  55. Liu XQ, Xue S, Xu JB, Ge H, Mao Q, Xu XH, Jiang HD. Clinical characteristics and related risk factors of disease severity in 101 COVID-19 patients hospitalized in Wuhan, China. Acta Pharmacol Sin. 2022;43(1):64-75.

  56. Zhao, Y., Lu, X., Wan, F., Gao, L., Lin, N., He, J., Wei, L., Dong, J., Qin, Z., Zhong, F., Qiao, Z., Wang, W., Ge, H., Ding, S., Yang, Y., Xiu, J., Shan, P., Yan, F., Zhao, S., Ji, Y., … Pu, J. (2022). Disruption of Circadian Rhythms by Shift Work Exacerbates Reperfusion Injury in Myocardial Infarction. Journal of the American College of Cardiology, 79(21), 2097–2115.

  57. Lai W, Chen-Xu Z, Jian-Xun D, Jie H, Ling-Cong K, Dong-Ao-Lei A, Bing-Hua C, Song D, Zheng L, Fan Y, Hu-Wen W, Jian-Rong X, Heng G, Jun P. Prognostic implications of left ventricular torsion measured by feature-tracking cardiac magnetic resonance in patients with ST-elevation myocardial infarction. Eur Heart J Cardiovasc Imaging. 2022:jeac177. Epub ahead of print. （通讯作者） JCR Q1

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