Biography

Diansan Su, Ph.D M.D. Mentor of Ph.D. Vice Chair of the Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine. He Got Ph.D from Shanghai Second Medical University at 2005. The interested research field are postoperative cognitive dysfunction(POCD) and the sedation of gastrointestinal endoscopy. He is the one who firstly found that POCD was mediated by intestinal dysbacteriosis. He finished the first national survey of on sedation for gastrointestinal endoscopy in 2758 Chinese hospitals. He introduced high flow nasal cannular(HFNC) into anesthesia. He demonstrated that HFNC would reduce the hypoxia during gastrointestinal endoscopy procedure sedated with propofol and the it would also reduce the hypoxia incidence during sedated hysteroscopy for assisted reproduction.He get six National Natural Science Foundation of China and hold 19 patents of China.

Publications

1. Zhou X, Dai W, Qin Y, Qi S, Zhang Y, Tian W, et al. Electroacupuncture relieves neuropathic pain by inhibiting degradation of the ecto-nucleotidase PAP in the dorsal root ganglions of CCI mice. Eur J Pain. 2022;26(5):15.

2. Zhang Y, Chen S, Tian W, Zhu H, Li W, Dai W, et al. Emerging Trends and Hot Spots in Sepsis-Associated Encephalopathy Research From 2001 to 2021: A Bibliometric Analysis. Front Med (Lausanne). 2022;9:817351.

3. Shi L, Zhou J, Jiang C, Dai W, Yu W, Xia Q, et al. A Bibliometric Analysis of the Landscape of Pediatric Liver Transplantation. Front Pediatr. 2022;10:805216.

4. Qin Y, Chen S, Zhang Y, Liu W, Lin Y, Chi X, et al. A Bibliometric Analysis of Endoscopic Sedation Research: 2001-2020. Front Med (Lausanne). 2022;8:775495.

5. Huang L, Tian W, Chen X, Xu H, Dai W, Zhang Y, et al. Peripheral Neutrophils-Derived Matrix Metallopeptidase-9 Induces Postoperative Cognitive Dysfunction in Aged Mice. Front Aging Neurosci. 2022;14:683295.

6. Zhu H, Cong L, Chen Y, Chen S, Chen L, Huang Z, et al. Efficiency of donepezil in elderly patients undergoing orthopaedic surgery due to underlying post-operative cognitive dysfunction: study protocol for a multicentre randomised controlled trial. Trials. 2021;22(1):688.

7. Zhou S, Zhu Z, Dai W, Qi S, Tian W, Zhang Y, et al. National survey on sedation for gastrointestinal endoscopy in 2758 Chinese hospitals. Br J Anaesth. 2021;S0007-0912(21)00079-9.

8. Zhao Y, Chen S, Huai X, Yu Z, Qi Y, Qing J, et al. Efficiency and Safety of the Selective Relaxant Binding Agent Adamgammadex Sodium for Reversing Rocuronium-Induced Deep Neuromuscular Block: A Single-Center, Open-Label, Dose-Finding, and Phase IIa Study. Front Med (Lausanne). 2021;8:697395.

9. Zhang R, Qi S, Dai W, Chen S, Zhang Y, Tian W, et al. Publication trends and hotspots in enhanced recovery after surgery: 20-year bibliometric analysis. Br J Surg. 2021;108(2):e62-e4.

10. Huai X JY, Gu X, Zhu H, Chen L, Fan Y, Yu W, Su D and Xie H. Preoperative Chronic Pain as a Risk Factor for Early Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Hip Joint Replacement Surgery: A Prospective Observational Cohort Study. Front Neurosci. 2021;15(747362).

11. Dai WB, Chen LK, Qi SY, Pan ZY, Zhang X, Huang LL, et al. Lactated Ringer's solution versus normal saline in pediatric living-donor liver transplantation: A matched retrospective cohort study. Paediatr Anaesth. 2021;31(6):10.

12. Zhou X, Lu J, Wu T, Jiang X, Tian W, Dai W, et al. Multiple Anesthesia/Surgery Cannot Impair Reference Memory in Adult Mice. Mediators Inflamm. 2020;2020:3736912.

13. Xuan W, Chen C, Jiang X, Zhang X, Zhu H, Zhang S, et al. Clinical characteristics and outcomes of five critical COVID-19 patients treated with extracorporeal membrane oxygenation in Leishenshan Hospital in Wuhan. J Clin Anesth. 2020;67:110033.

14. Pan ZY, Fan YC, Wang XQ, Chen LK, Zou QQ, Zhou T, et al. Pediatric living donor liver transplantation decade progress in Shanghai: Characteristics and risks factors of mortality. World J Gastroenterol. 2020;26(12):1352-64.

15. Chen S, Zhang Y, Dai W, Qi S, Tian W, Gu X, et al. Publication trends and hot spots in postoperative cognitive dysfunction research: A 20-year bibliometric analysis. J Clin Anesth. 2020;67:110012.

16. Chen L, Zhang S, Tian W, Huang L, Jiang X, Chen X, et al. Cerebral spinal fluid cholinergic biomarkers predict postoperative cognitive dysfunction in aged patients - A prospective, observational, single center study. J Clin Anesth. 2020;62:109743.

17. Chen L, Yang L, Tian W, Zhang X, Zhao Y, Huang L, et al. Transnasal Humidified Rapid Insufflation Ventilatory Exchange With Nasopharyngeal Airway Facilitates Apneic Oxygenation: A Randomized Clinical Noninferiority Trial. Front Med (Lausanne). 2020;7:577891.

18. Zhou X, Chen L, Su Z, Li Y, Tu M, Xiao J, et al. Perioperative acute myocardial infarction in patients after non-cardiac surgery in China: Characteristics and risk factors. Medicine (Baltimore). 2019;98(34):e16929.

19. Xu H, Chen L, Zhang X, Jiang X, Tian W, Yu W, et al. Central cholinergic neuronal degeneration promotes the development of postoperative cognitive dysfunction. Lab Invest. 2019;99(7):1078-88.

20. Lin Y, Zhang X, Li L, Wei M, Zhao B, Wang X, et al. High-flow nasal cannula oxygen therapy and hypoxia during gastroscopy with propofol sedation: a randomized multicenter clinical trial. Gastrointest Endosc. 2019;90(4):591-601.

21. Jiang XL, Gu XY, Zhou XX, Chen XM, Zhang X, Yang YT, et al. Intestinal dysbacteriosis mediates the reference memory deficit induced by anaesthesia/surgery in aged mice. Brain Behav Immun. 2019;80:605-15.

22. Zheng HR, Zhang XQ, Li LZ, Wang YL, Wei Y, Chen YM, et al. Multicentre prospective cohort study evaluating gastroscopy without sedation in China. Br J Anaesth. 2018;121(2):508-11.

23. Zhang X, Jiang X, Huang L, Tian W, Chen X, Gu X, et al. Central cholinergic system mediates working memory deficit induced by anesthesia/surgery in adult mice. Brain Behav. 2018;8(5):e00957.

24. Liu X, Yang H, Liu Y, Jiao Y, Yang L, Wang X, et al. Remifentanil upregulates hepatic IL-18 binding protein (IL-18BP) expression through transcriptional control. Lab Invest. 2018;98(12):1588-99.

25. Zhang L, Ding L, Li M, Zhang X, Su D, Jia J, et al. Dual-Wavelength Laser Speckle Contrast Imaging (dwLSCI) Improves Chronic Measurement of Superficial Blood Flow in Hands. Sensors (Basel). 2017;17(12).

26. Qin Y, Li LZ, Zhang XQ, Wei Y, Wang YL, Wei HF, et al. Supraglottic jet oxygenation and ventilation enhances oxygenation during upper gastrointestinal endoscopy in patients sedated with propofol: a randomized multicentre clinical trial. BJA: British Journal of Anaesthesia. 2017;119(1):158-66.

27. Zhao Y, Huang L, Xu H, Wu G, Zhu M, Tian J, et al. Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult Mice. Mediators Inflamm. 2016;2016:3271579.

28. Xu H, Lu B, Zheng B, Tian J, Qi B, Deng Y, et al. Smaller Sized Inhaled Anesthetics have More Potency on Senescence-Accelerated Prone-8 Mice Compared with Senescence-Resistant-1 Mice. Journal of Alzheimer's disease : JAD. 2014;39(1):29-34.

29. Tian J, Gu Y, Sun K, Wang B, Chen J, Wang X, et al. [D-Ala2, D-Leu5] encephalin (DADLE) reversibly inhibits cellular transcription in neurons without causing cell injury. Brain Res. 2014;1565:1-7.

30. Yuan L, Su D, Liu X, Lu H, Li Y, Tong S. Cerebral blood flow changes during rat cardiopulmonary bypass and deep hypothermic circulatory arrest model: A preliminary study. Conference proceedings :  Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference. 2013;2013:1807-10.

31. Yang Z, Deng Y, Su D, Tian J, Gao Y, He Z, et al. TLR4 as receptor for HMGB1-mediated acute lung injury after liver ischemia/reperfusion injury. Lab Invest. 2013;93(7):792-800.

32. Li W, Zheng B, Xu H, Deng Y, Wang S, Wang X, et al. Isoflurane prevents neurocognitive dysfunction after cardiopulmonary bypass in rats. Journal of cardiothoracic and vascular anesthesia. 2013;27(3):502-9.

33. Zheng YJ, Wang XR, Chen HZ, Wu XJ, Zhao YH, Su DS. Protective effects of the delta opioid peptide [D-Ala2, D-Leu5]enkephalin in an ex vivo model of ischemia/reperfusion in brain slices. CNS neuroscience & therapeutics. 2012;18(9):762-6.

34. Su D, Zhao Y, Xu H, Wang B, Chen X, Chen J, et al. Isoflurane Exposure during Mid-Adulthood Attenuates Age-Related Spatial Memory Impairment in APP/PS1 Transgenic Mice. PloS one. 2012;7(11):e50172.

35. Su D, Riley J, Armstead WM, Liu R. Salvinorin A Pretreatment Preserves Cerebrovascular Autoregulation After Brain Hypoxic/Ischemic Injury via Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase in Piglets. Anesth Analg. 2012;114(1):200-4.

36. Wang S, Duan Y, Su D, Li W, Tan J, Yang D, et al. Delta opioid peptide [D-Ala2, D-Leu5] enkephalin (DADLE) triggers postconditioning against transient forebrain ischemia. Eur J Pharmacol. 2011;658(2-3):140-4.

37. Su D, Zhao Y, Wang B, Xu H, Li W, Chen J, et al. Isoflurane-Induced Spatial Memory Impairment in Mice is Prevented by the Acetylcholinesterase Inhibitor Donepezil. PloS one. 2011;6(11):e27632.

38. Su D, Zhao Y, Wang B, Li W, Xiao J, Chen J, et al. Repeated but not single isoflurane exposure improved the spatial memory of young adult mice. Acta Anaesthesiol Scand. 2011;55(4):468-73.

39. Su D, Riley J, Kiessling WJ, Armstead WM, Liu R. Salvinorin A produces cerebrovasodilation through activation of nitric oxide synthase, kappa receptor, and adenosine triphosphate-sensitive potassium channel. Anesthesiology. 2011;114(2):374-9.

40. Duan YL, Wang SY, Zeng QW, Su DS, Li W, Wang XR, et al. Astroglial reaction to delta opioid peptide [d-Ala2, d-Leu5] enkephalin confers neuroprotection against global ischemia in the adult rat hippocampus. Neuroscience. 2011;192:81-90.