Ottawa-Shanghai Joint School of Medicine



Chief Physician


Tel: 021-68385528

Research Fields: The molecular mechanism and treatment of coronary heart disease and myocardial infarction.


A doctor of medicine, Chief Physician, Doctoral Supervisor, Attending doctor of Cardiology Department of Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine; a postdoctoral fellow in the Department of Cardiology, Zhongshan Hospital Affiliated to Fudan University from 2004 to 2006; serves as the deputy director (vice chairman) of the Cardiac Acute and Critical Care Professional Committee of the Chinese Medical Doctor Association, the deputy head of the National Cardiovascular Acute and Critical Care Group of the Tenth Committee of the Chinese Medical Association Cardiovascular Disease Branch, the chairman of the Yangtze River Delta Cardiovascular Acute and Critical Care Alliance, the head of the Cardiac Acute and Critical Care Working Group of Shanghai Medical Doctor Association. In recent years, has been invited as a core expert to participate in the preparation of 17 consensuses on various cardiovascular-related guidelines; as a member of the expert group, participated in the preparation of Guidelines for the prevention, diagnosis and treatment of infective endocarditis in adults, published in Eur Heart J (Impact Factor: 30); has presided over 11 scientific research projects, included the National Natural Science Foundation of China or provincial and ministerial scientific research projects, etc; has published more than 60 papers, including more than 30 SCI papers; serves as a special reviewer for the core journals "Journal of the Chinese Academy of Medical Sciences", "Journal of Shanghai Jiaotong University" and "Journal of Zhejiang University"; and to be an editorial board member of the "Chinese Journal of Heart Failure and Cardiomyopathy", a series of journals of the Chinese Medical Association; has independently recruited and trained more than 20 post-doctoral, doctoral and master students; edited one monograph as chief editor, and participated in the editing of several monographs, such as “Practical Cardiology”, National Higher Education Medical Planning Network Electronic Textbook "Internal Medicine" and “ECMO”.


  1. Yuheng Jiao#, Yanyan Li#, Jiayan Zhang, Yafang Zha, Jian Wang, Song Zhang*. RRM2 Alleviates Doxorubicin-Induced Cardiotoxicity through the AKT/mTOR Signaling Pathway. Biomolecules. 2022 Feb 12;12(2):299.

  2. Yafang Zha#, Yanyan Li#, Zhuowang Ge#, Jian Wang, Yuheng Jiao, Jiayan Zhang, Song Zhang*. ADAMTS8 Promotes Cardiac Fibrosis Partly Through Activating EGFR Dependent Pathway. Front. Cardiovasc. Med. 2022 Feb 10 |

  3. Jiayan Zhang#, Yafang Zha#, Yuheng Jiao#, Yanyan Li, Jian Wang, Song Zhang*. OTUD7B (Cezanne) Ameliorates Fibrosis After Myocardial Infarction via FAK-ERK/P38 MAPK Signaling Pathway. Archives of biochemistry and biophysics, v: 724, 2022

  4. Yuheng Jiao#, Yanyan Li#, Song Zhang*, Yafang Zha, Xiaowei Meng, Jiayan Zhang. The effects of sacubitril/valsartan on heart failure with preserved ejection fraction: a meta-analysis. Acta Cardiol. 2021 Aug 11:1-9.

  5. Changlin Zhai#, Yinggang Sun#, Gang Qian, Haihua Pan, Shuoyin Xie, Zhewei Sun, Song Zhang*, Huilin Hu*. LncRNA AK087124/miR-224-5p/PTEN axis modulates endothelial cell injury in atherosclerosis through apoptosis and AKT signaling pathway. Arch Biochem Biophys. Arch Biochem Biophys. 2021 Jul 15;705:108916.

  6. Changlin Zhai#, Gang Qian#, Huajun Wu, Haihua Pan, Shuoyin Xie, Zhewei Sun, Pingyang Shao, Guanmin Tang, Huilin Hu, Song Zhang*. Knockdown of circ_0060745 alleviates acute myocardial infarction by suppressing NF-κB activation. J Cell Mol Med. 2020 Nov;24(21):12401-12410.

  7. Jie Yang#, Xufang Yu, YanYan Li, Fengtai Xue, Zhang Song*. Decreased HSP70 expression on serum exosomes contributes to cardiac fibrosis during senescence. Eur Rev Med Pharmacol Sci. 2019 May;23(9):3993-4001.

  8. Changlin Zhai#, Guanmin Tang, Gang Qian, Huilin Hu, Shijun Wang, Dong Yin, Song Zhang*. MicroRNA-98 attenuates cardiac ischemia-reperfusion injury through inhibiting DAPK1 expression. IUBMB Life. 2019 Feb;71(2):166-176.

  9. Jie Yang#, Fengtai Xue, Yanyan Li, Wei Liu, Song Zhang*. Exosomal piRNA sequencing reveals differences between heart failure and healthy patients. Eur Rev Med Pharmacol Sci. 2018 Nov;22(22):7952-7961.

  10. Changlin Zhai#, Guanmin Tang#, Gang Qian, Bingjiang Han, Huilin Hu, Shijun Wang, Dong Yin, Haihua Pan, Song Zhang*. miR-190 protects cardiomyocytes from apoptosis induced by H2O2 through targeting MAPK8 and regulating MAPK8/ERK signal pathway. Int J Clin Exp Pathol. 2018 Apr 1;11(4):2183-2192.

  11. Jie Yang#, Xufang Yu#, Fengtai Xue, Yanyan Li, Wei Liu, Song Zhang*. Exosomes derived from cardiomyocytes promote cardiac fibrosis via myocyte-fibroblast cross-talk. Am J Transl Res. 2018 Dec 15;10(12):4350-4366.

  12. Yanyan Li#, Yin Xiang#, Song Zhang*, Yan Wang, Jie Yang, Wei Liu, Fengtai Xue. Thioredoxin-2 protects against oxygen-glucose deprivation/reperfusion injury by inhibiting autophagy and apoptosis in H9c2 cardiomyocytes. Am J Transl Res. 2017 Mar 15;9(3):1471-1482.

  13. Changlin Zhai#, Qang Qian#, Guanmin Tang, Bingjiang Han, Huilin Hu, Dong Yin, Haihua Pan, Song Zhang*. MicroRNA-206 Protects against Myocardial Ischaemia-Reperfusion Injury in Rats by Targeting Gadd45β. Mol Cells. 2017 Dec 31;40(12):916-924.

  14. Shan Jiang#, Song Zhang*. Differentiation of cardiomyocytes from amniotic fluid derived mesenchymal stem cells by combined induction with transforming growth factor β1 and 5 azacytidine. Mol Med Rep. 2017 Nov;16(5):5887-5893.

  15. Jie Yang#, Yanyan Li#, Fengtai Xue, Wei Liu, Song Zhang*.  Exosomes derived from cardiac telocytes exert positive effects on endothelial cells. Am J Transl Res. 2017 Dec 15;9(12):5375-5387.

  16. Yan Wang#, Shuyan Chen#, Yanhong Gao, Song Zhang*. Serum MicroRNA-27b as a Screening Biomarker for Left Ventricular Hypertrophy. Tex Heart Inst J. 2017 Dec 19;44(6):385-389.

  17. Yanyan Li#, Yin Xiang# , Song Zhang*, Yan Wang, Jie Yang, Wei Liu, Fengtai Xue. Intramyocardial injection of thioredoxin 2-expressing lentivirus alleviates myocardial ischemia-reperfusion injury in rats. Am J Transl Res. 2017 Oct 15;9(10):4428-4439.