Ottawa-Shanghai Joint School of Medicine


LI Pengying

Associate chief physician


Tel: 15800616866

Research Fields: 缺血性脑损伤的机制及神经保护/围术期脑损伤及保护的临床研究


Peiying Li is the director of Clinical Research Center in Renji Hospital. She has received awards including National Outstanding Young Investigator from Natural Science Foundation of China (NSFC), Newton Advanced Fellowship from the UK Academy of Medical Sciences, Outstanding Academic Leaders from Shanghai Municipal Science and Technology Committee, Shanghai Rising-Star by Shanghai Natural Science Committee, and Shuguang Program supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission. Her research interest is on immune regulation in ischemic brain injury and perioperative neuroprotection. She has published more than 30 SCI papers in Brain, Annals of Neurology, Stroke and other journals as the first or corresponding author, these articles have been cited more than 1000 times. Professor Peiying Li has taken charge of 11 scientific research projects, which contain 5 projects from NSFC, including major research programs and China-UK academic project. She received the Niels Lassen Award presented by the International Society for Cerebral Blood Flow and Metabolism (ISCBFM), and was the first Chinese young scientist to get this award. She was also the co-chair of 2022 UK Glasgow Brain Conference raised by ISCBFM. Currently, Professor Peiying Li is the associate editor for Journal of Cerebral Blood Flow & Metabolism and CNS Neuroscience & Therapeutics, and the editorial board member for Stroke and Neuropharmacology.


  1. Chen, W., Zhang, Y., Zhai, X., Xie, L., Guo, Y., Chen, C., Li, Y., Wang, F., Zhu, Z., Zheng, L., Wan, J., & Li, P. (2022). Microglial phagocytosis and regulatory mechanisms after stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 42(9), 1579–1596.

  2. Liu, B., Huang, D., Guo, Y., Sun, X., Chen, C., Zhai, X., Jin, X., Zhu, H., Li, P., & Yu, W. (2022). Recent advances and perspectives of postoperative neurological disorders in the elderly surgical patients. CNS neuroscience & therapeutics, 28(4), 470–483.

  3. Guo, Y., & Li, P. (2022). Recent highlights in periopeative neurological disorders, from bench to bedside. CNS neuroscience & therapeutics, 28(4), 467–469.

  4. Xie, W., & Li, P. (2021). Visualizing regulatory lymphocytic responses to predict neurological outcome after stroke. CNS neuroscience & therapeutics, 27(8), 867–868.

  5. Zhang, Y., Li, F., Chen, C., Li, Y., Xie, W., Huang, D., Zhai, X., Yu, W., Wan, J., & Li, P. (2022). RAGE-mediated T cell metabolic reprogramming shapes T cell inflammatory response after stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 42(6), 952–965.

  6. Chen, C., Huang, T., Zhai, X., Ma, Y., Xie, L., Lu, B., Zhang, Y., Li, Y., Chen, Z., Yin, J., & Li, P. (2021). Targeting neutrophils as a novel therapeutic strategy after stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 41(9), 2150–2161.

  7. Zhang, Y., Liesz, A., & Li, P. (2021). Coming to the Rescue: Regulatory T Cells for Promoting Recovery After Ischemic Stroke. Stroke, 52(12), e837–e841.

  8. Xie, L., Lu, B., Ma, Y., Yin, J., Zhai, X., Chen, C., Xie, W., Zhang, Y., Zheng, L., & Li, P. (2021). The 100 most-cited articles about the role of neurovascular unit in stroke 2001-2020: A bibliometric analysis. CNS neuroscience & therapeutics, 27(7), 743–752.

  9. Chen, W., Xie, L., Yu, F., Li, Y., Chen, C., Xie, W., Huang, T., Zhang, Y., Zhang, S., & Li, P. (2021). Zebrafish as a Model for In-Depth Mechanistic Study for Stroke. Translational stroke research, 12(5), 695–710.

  10. Huang, T., Li, Y., Zhou, Y., Lu, B., Zhang, Y., Tang, D., Gan, Y., He, Z., Chen, Z., Yu, W., & Li, P. (2020). Stroke Exacerbates Cancer Progression by Upregulating LCN2 in PMN-MDSC. Frontiers in immunology, 11, 299.

  11. Yu, S., & Li, P. (2020). Cognitive declines after perioperative covert stroke: Recent advances and perspectives. Current opinion in anaesthesiology, 33(5), 651–654.

  12. Li, Y., Zhu, Z. Y., Lu, B. W., Huang, T. T., Zhang, Y. M., Zhou, N. Y., Xuan, W., Chen, Z. A., Wen, D. X., Yu, W. F., & Li, P. Y. (2019). Rosiglitazone ameliorates tissue plasminogen activator-induced brain hemorrhage after stroke. CNS neuroscience & therapeutics, 25(12), 1343–1352.

  13. Li, Y., Xie, L., Huang, T., Zhang, Y., Zhou, J., Qi, B., Wang, X., Chen, Z., & Li, P. (2019). Aging Neurovascular Unit and Potential Role of DNA Damage and Repair in Combating Vascular and Neurodegenerative Disorders. Frontiers in neuroscience, 13, 778.

  14. Zhu, Z., Zheng, L., Li, Y., Huang, T., Chao, Y. C., Pan, L., Zhu, H., Zhao, Y., Yu, W., & Li, P. (2019). Potential Immunotherapeutic Targets on Myeloid Cells for Neurovascular Repair After Ischemic Stroke. Frontiers in neuroscience, 13, 758.

  15. Wang, X., Zhou, Y., Tang, D., Zhu, Z., Li, Y., Huang, T., Müller, R., Yu, W., & Li, P. (2019). ACC1 (Acetyl Coenzyme A Carboxylase 1) Is a Potential Immune Modulatory Target of Cerebral Ischemic Stroke. Stroke, 50(7), 1869–1878.

  16. Zhou, Y. X., Wang, X., Tang, D., Li, Y., Jiao, Y. F., Gan, Y., Hu, X. M., Yang, L. Q., Yu, W. F., Stetler, R. A., Li, P. Y., & Wen, D. X. (2019). IL-2mAb reduces demyelination after focal cerebral ischemia by suppressing CD8+ T cells. CNS neuroscience & therapeutics, 25(4), 532–543.

  17. Wang, X., Xuan, W., Zhu, Z. Y., Li, Y., Zhu, H., Zhu, L., Fu, D. Y., Yang, L. Q., Li, P. Y., & Yu, W. F. (2018). The evolving role of neuro-immune interaction in brain repair after cerebral ischemic stroke. CNS neuroscience & therapeutics, 24(12), 1100–1114.

  18. Li, Y., Zhu, Z. Y., Huang, T. T., Zhou, Y. X., Wang, X., Yang, L. Q., Chen, Z. A., Yu, W. F., & Li, P. Y. (2018). The peripheral immune response after stroke-A double edge sword for blood-brain barrier integrity. CNS neuroscience & therapeutics, 24(12), 1115–1128.

  19. Li, P., Stetler, R. A., Leak, R. K., Shi, Y., Li, Y., Yu, W., Bennett, M., & Chen, J. (2018). Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery. Neuropharmacology, 134(Pt B), 208–217.

  20. Wang, L., Zhou, Y., Yin, J., Gan, Y., Wang, X., Wen, D., Thomson, A. W., Hu, X., Yang, L., Stetler, R. A., Li, P., & Yu, W. (2018). Cancer Exacerbates Ischemic Brain Injury Via Nrp1 (Neuropilin 1)-Mediated Accumulation of Regulatory T Cells Within the Tumor. Stroke, 49(11), 2733–2742.

  21. Mao, L., Li, P., Zhu, W., Cai, W., Liu, Z., Wang, Y., Luo, W., Stetler, R. A., Leak, R. K., Yu, W., Gao, Y., Chen, J., Chen, G., & Hu, X. (2017). Regulatory T cells ameliorate tissue plasminogen activator-induced brain haemorrhage after stroke. Brain : a journal of neurology, 140(7), 1914–1931.

  22. Li, P., Wang, L., Zhou, Y., Gan, Y., Zhu, W., Xia, Y., Jiang, X., Watkins, S., Vazquez, A., Thomson, A. W., Chen, J., Yu, W., & Hu, X. (2017). C-C Chemokine Receptor Type 5 (CCR5)-Mediated Docking of Transferred Tregs Protects Against Early Blood-Brain Barrier Disruption After Stroke. Journal of the American Heart Association, 6(8), e006387.

  23. Leak, R. K., Li, P., Zhang, F., Sulaiman, H. H., Weng, Z., Wang, G., Stetler, R. A., Shi, Y., Cao, G., Gao, Y., & Chen, J. (2015). Apurinic/apyrimidinic endonuclease 1 upregulation reduces oxidative DNA damage and protects hippocampal neurons from ischemic injury. Antioxidants & redox signaling, 22(2), 135–148.

  24. Li, P., Mao, L., Liu, X., Gan, Y., Zheng, J., Thomson, A. W., Gao, Y., Chen, J., & Hu, X. (2014). Essential role of program death 1-ligand 1 in regulatory T-cell-afforded protection against blood-brain barrier damage after stroke. Stroke, 45(3), 857–864.

  25. An, C., Shi, Y., Li, P., Hu, X., Gan, Y., Stetler, R. A., Leak, R. K., Gao, Y., Sun, B. L., Zheng, P., & Chen, J. (2014). Molecular dialogs between the ischemic brain and the peripheral immune system: dualistic roles in injury and repair. Progress in neurobiology, 115, 6–24.

  26. Li, P., Gan, Y., Sun, B. L., Zhang, F., Lu, B., Gao, Y., Liang, W., Thomson, A. W., Chen, J., & Hu, X. (2013). Adoptive regulatory T-cell therapy protects against cerebral ischemia. Annals of neurology, 74(3), 458–471.

  27. Li, P., Mao, L., Zhou, G., Leak, R. K., Sun, B. L., Chen, J., & Hu, X. (2013). Adoptive regulatory T-cell therapy preserves systemic immune homeostasis after cerebral ischemia. Stroke, 44(12), 3509–3515.

  28. Li, P., Hu, X., Gan, Y., Gao, Y., Liang, W., & Chen, J. (2011). Mechanistic insight into DNA damage and repair in ischemic stroke: exploiting the base excision repair pathway as a model of neuroprotection. Antioxidants & redox signaling, 14(10), 1905–1918.