Ottawa-Shanghai Joint School of Medicine



Associate Professor


Tel: 18616206596

Research Interests: Impacts of anesthesia on tumor outcomes  Postoperative cognitive dysfunction (POCD)


Dr. TIAN Jie is an Associate Senior Physician, Supervisor of postgraduates, Vice Director of the Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine and Vice Director of the Youth Committee of the Shanghai Association of Anesthesiology. She has been actively engaged and has extensive experience in clinical anesthesia, with an expertise in neurosurgical anesthesia and is the head of the Neurosurgical Anesthesia Subgroup in the Department of Anesthesiology. Her research interests are the impacts of anesthesia on tumor progression and postoperative cognitive dysfunction (POCD). She has published more than 20 research articles in the Journal of Clinical Investigation and other academic journals as the first author or corresponding author. She has been funded multiple research projects at national- or provincial-level, including National Natural Science Foundation of China and Shanghai Natural Science Foundation of China, etc. The English course "Anesthesiology" taken charge by Dr. Tian has been awarded as a key university course in Shanghai. She has received the Shanghai Jiao Tong University Medical School Apricot Grove Yucai Award and the Shanghai Jiao Tong University Medical School Outstanding Teacher Award.


  1. Wang X#, Li Y#, Shi Y#, Luo J, Zhang Y, Pan Z, Wu F, Tian J*, Yu W*. Comprehensive Analysis to Identify the Neurotransmitter Receptor-related Genes as Prognostic and Therapeutic Biomarkers in Hepatocellular Carcinoma, Frontiers in Cell and Developmental Biology,

  2. Shi Y#, Luo J#, Wang X#, Zhang Y, Su D, Yu W*, Tian J*. Emerging trends on the correlation between neurotransmitters and tumor progression in the last 20 years: A bibliometric analysis via CiteSpace. Frontiers in Oncology; 2022, 12:800499.

  3. Shi Y#, Wu T#, Wang T#, Liu Y, Wang X, Luo J, Su D, Zhai B*, Tian J*. Effects of serum from radiofrequency ablation patients receiving general anesthesia or local anesthesia on hepatocellular carcinoma cancer cell malignancy: A prospective randomized controlled trial. Frontiers in Oncology;2021, 11:686294.

  4. Luo J#, Shi Y#, Wang X, Zhang R, Chen S, Yu W, Su D*, Tian J*. A 20-Year Research Trend Analysis of the Influence of Anesthesia on Tumor Prognosis Using Bibliometric Methods. Frontiers in Oncology, 2021;11:683232.

  5. Wang X#, Zhang R#, Wu T, Shi Y, Zhou X, Tang D, Yu W, So EC, Wu X, Pan Z*, Tian J*. Successive treatment with naltrexone induces epithelial-mesenchymal transition and facilitates the malignant biological behaviors of bladder cancer cells. Acta Biochimica et Biophysica Sinica (Shanghai), 2021;53(2):238-248.

  6. Zhang R#, Qi S#, Dai W, Zhang Y, Chen S, Tian W, Kong M, Yan W, Tian J*, Su D*. Publication trends and hotspots in enhanced recovery after surgery: 20-year bibliometric analysis. British Journal of Surgery, 2021;108(2):e62-e64.

  7. Chen S#, Zhang Y, Dai W, Qi S, Tian W, Gu X, Chen X, Yu W, Tian J*, Su D*. Publication trends and hot spots in postoperative cognitive dysfunction research: A 20-year bibliometric analysis. Journal of Clinical Anesthesia, 2020;67:110012.

  8. Wang X#, Xie W#, Gan S#, Wang T, Chen X, Su D, Sun J, Lin J, Wu F, Xu P, Miao C, Yan M, Zhu S, Zhai B, Sun Y*, Yu W*, Tian J*. Effects of general anesthesia versus local anesthesia in primary hepatocellular carcinoma patients presenting for thermal ablation surgery: A multiple center retrospective cohort study with propensity score matching. Annals of Translational Medicine, 2020;8(6):277-289.

  9. Wu T#, Wang X#, Zhang R, Jiao Y, Yu W, Su D, Zhao Y*, Tian J*. Mice with pre-existing tumors are vulnerable to postoperative cognitive dysfunction. Brain Research, 2020;1732:146650.

  10. Liu Y#, Sun J#, Lu X, Du Y, Duan H, Yu W, Su D, Lu J*, Tian J*. Effects of serum from breast cancer surgery patients receiving perioperative dexmedetomidine on breast cancer cell malignancy: A prospective randomized controlled trial. Cancer Medicine, 2019;8(18):7603-7612.

  11. Lin Y#, Zhang X#, Li L#, Wei M, Zhao B, Wang X, Pan Z, Tian J*, Yu W*, Su D*. High-flow nasal cannula oxygen therapy and hypoxia during gastroscopy with propofol sedation: a randomized multicenter clinical trial. Gastrointestinal Endoscopy, 2019;90(4):591-601.

  12. Xu H#, Chen L#, Zhang X, Jiang X, Tian W, Yu W, Wang X, Tian J*, Su D*. Central cholinergic neuronal degeneration promotes the development of postoperative cognitive dysfunction. Laboratory Investigation, 2019; 99(7):1078-1088.

  13. Liu X#, Yang H#, Liu Y, Jiao Y, Yang L, Wang X, Yu W, Su D*, Tian J*. Remifentanil upregulates hepatic IL-18 binding protein (IL-18BP) expression through transcriptional control. Laboratory Investigation, 2018; 98(12): 1588-1599.

  14. Zhang X#, Jiang X#, Huang L, Tian W, Chen X, Gu X, Yu W, Tian J*, Su D*. Central cholinergic system mediates working memory deficit induced by anesthesia/surgery in adult mice. Brain and Behavior, 2018; 8: e00957.

  15. Liu X#, Pan Z, Su D, Yang Z, Zheng B, Wang X*, Tian J*. Remifentanil ameliorates liver ischemia/reperfusion injury through inhibition of IL-18 signaling. Transplantation, 2015; 99(10): 2109-2117.

  16. Tian J#, Gu Y#, Sun K, Wang B, Chen J, Wang X*, Su D*. [D-Ala2, D-Leu5] encephalin (DADLE) reversibly inhibits cellular transcription in neurons without causing cell injury. Brain Research, 2014; 1565: 1-7.

  17. Tian J#, Berton TR, Shirley SH, Lambertz I, Gimenez-Conti IB, DiGiovanni J, Korach KS, Conti CJ, Fuchs-Young R*. Developmental stage determines estrogen receptor alpha expression and non-genomic mechanisms that control IGF-1 signaling and mammary proliferation in mice. the Journal of Clinical Investigation, 2012; 122(1): 192-204.

  18. Tian J#, Lambertz I, Berton TR, Rundhaug JE, Kiguchi K, Shirley SH, DiGiovanni J, Conti CJ, Fischer SM, Fuchs-Young R*. Transgenic insulin-like growth factor-1 stimulates activation of COX-2 signaling in mammary glands. Molecular Carcinogenesis, 2012; 51(12): 973-983.

  19. Tian J#, Wang Y, He Z, Gao Y, Rundhaug JE, Wang X*. Hydroxyethyl starch (130 kD) inhibits Toll-Like Receptor 4 signaling pathways in rat lungs challenged with lipopolysaccharide. Anesthesia and Analgesia, 2011; 113(1): 112-119.

  20. Tian J#, Gu Y#, Su D, Wu Y, Wang X*. Effects of intrathecal lidocaine on hyperalgesia and allodynia following chronic constriction injury in rats. European Journal of Pain, 2009; 13(2): 130-137.

  21. Tian J#, Lin X, Li YH, Xu JG*. Influence of hydroxyethyl starch on lipopolysaccharide-induced tissue nuclear factor kappa B activation and systemic TNF-α expression. Acta Anaesthesiologica Scandinavica, 2005;49(9):1311-1317.

  22. Tian J#, Lin X, Guan R, Xu JG*. The effects of hydroxyethyl starch on lung capillary permeability in endotoxic rats and possible mechanisms. Anesthesia and Analgesia, 2004; 98(3): 768-774.

  23. Tian J#, Lin X, Zhou W, Xu J*. Hydroxyethyl starch inhibits NF-kappaB activation and prevents the expression of inflammatory mediators in endotoxic rats. Annals of Clinical and Laboratory Science, 2003; 33(4): 451-458.