Ottawa-Shanghai Joint School of Medicine


LI Xia

Chief Physician

Dementia especially Alzheimer’s Disease

Molecular genetics and biochemistry of dementia and mood disorder


Tel: 021-34773440


  • September 2008~June 2011: Ph.D study in Psychiatry, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine.

  • September 2000~June 2003: Master of Science in Psychiatry. Department of Psychiatry, Tongji University.

  • September 1989~July 1992: Special Course of Study. Department of Medicine, Jinggangshan Medical College.

Current position

  • Chief director. Consult psychogeriatrist, Department of psycho geriatrics, Shanghai Mental Health Center. China

  • Consult psychogeriatrist, deputy director, Alzheimer Disease Center of Shanghai Jiaotong University school of medicine.

  • Vice group leader, group of psychogeriatrics, Chinese Psychiatrist Association.

  • Standing Committee member and deputy secretary-general, Alzheimer's Disease China.


  • Collaborative Innovation Center for Clinical  and Translational Science by Ministry of Education & Shanghai, 2022-2024(Code:CCTS-202203)

  • Project of “Technical Standards for Artificial Intelligence-Assisted Assessment of Cognitive Functioning in the Elderly” supported by Shanghai Science and Technology Commission "Science and Technology Innovation Action Plan" Technical Standards Project,2022-2024(Code:22DZ2205800)

  • Project of “A real-world study and exploratory intervention on digital treatment acceptance among Elderly” supported by Clinical Research Center, Shanghai Mental Health Center, 2021-2025(Code:CRC2021ZC01)

  • Project of “Tiered screening and community intervention for risk of cognitive impairment in the elderly” supported by Fifth Three-year Action Plans for Public Health, 2020-2022(Code: GWV-9.2)

  • Director of the sub-center, Project of “Development of a cohort of senile deafness and prevention and management strategies” suppoorted by Shanghai Shenkang Hospital Development Center Major Clinical Research Project, 2020.7-2022.12 (Code:SHDC2020CR1044B)

  • Project of ”A cohort and promotion of a intelligent musical movement blanket intervention for mild cognitive impairment in the community” supported by Advanced and Appropriate Technology Promotion Project of Shanghai Health and Health Commission,2019-2022(Code:2019SY045)

  • Being in charge of Project of National Key R&D Program of China: “To build up following-up management model in neurocognitive impairment based on China communities”, 2017-2020.(Code. 2017YFC1310500)

  • Project of “Remember that I love you—know more about cognitive disorders from short video” supported by Science and Technology Commission of Shanghai Municipality, 2017-2019(Code 17dz2305800)

  • Project of “A longitudinal study on miR132/212 regulating neuroprotective factors as predictors for outcome of late-life depression” approved by National Natural Science Foundation Committee (NSFC), 2016-2020(Code.81671402)

  • Being in charge of project of “PST application and MiRNA132/BDNF regulatory pathway as a peripheral marker in senile depression, 2015-2018(Code. 15411961400)

  • Project of “research on MicroRNA-16 regulating serotonin transporter in Depression” approved by National Natural Science Foundation Committee (NSFC). 2011-2014 (Code: 81101007).


  • "A Cognitive Self-Assessment Scale for the Elderly" . First Prize in the 11th Shanghai Medical Science and Technology Innovation "Starlight Plan".2021

  • "I only know you" - a series of warm scientific popularization of Alzheimer's disease. Chinese Medical Association Award for Popularization of Medical Science and Technology. 2021

  • Scientific Research Achievement Second Prize. Shanghai Jiao Tong University. 2021

  • Record of "I Only Know You" - "Professional and Warm" Alzheimer's Disease Science Education. First Prize, Shanghai Science and Technology Award - Science and Technology Popularization Award. 2020

  • Shanghai Science and Technology Shanghai Science Education Innovation Award Individual Second Prize.2019

  • “Shanghai March Eighth red banner pacesetter” “woman heroes” award by shanghai government, 2017.

Publications (parts of)

  • Nie J, Fang Y, Chen Y, Aidina A, Qiu Q, Zhao L, Liu X, Sun L, Li Y, Zhong C, Li Y, Li X. Characteristics of Dysregulated Proinflammatory Cytokines and Cognitive Dysfunction in Late-Life Depression and Amnestic Mild Cognitive Impairment. Front Immunol. 2022 Jan 5;12:803633. doi: 10.3389/fimmu.2021.803633. PMID: 35069588; PMCID: PMC8767092. (IF:8.786)

  • Du Y, Yan F, Zhao L, Fang Y, Qiu Q, Wei W, Wang J, Tang Y, Lin X, Li X. Depression symptoms moderate the relationship between gray matter volumes and cognitive function in patients with mild cognitive impairment. J Psychiatr Res. 2022 May 23;151:516-522. doi: 10.1016/j.jpsychires.2022.05.017. (IF: 5.25)

  • Du Y, Zhang S, Fang Y, Qiu Q, Zhao L, Wei W, Tang Y, Li X. Radiomic Features of the Hippocampus for Diagnosing Early-Onset and Late-Onset Alzheimer's Disease. Front Aging Neurosci. 2022 Jan 26;13:789099. doi: 10.3389/fnagi.2021.789099. PMID: 35153721; PMCID: PMC8826454. (IF: 5.702)

  • Zhang S, Qiu Q, Qian S, Lin X, Yan F, Sun L, Xiao S, Wang J, Fang Y, Li X. Determining Appropriate Screening Tools and Cutoffs for Cognitive Impairment in the Chinese Elderly. Front Psychiatry. 2021 Dec 2;12:773281. doi: 10.3389/fpsyt.2021.773281. PMID: 34925100; PMCID: PMC8674928. (IF: 5.435)

  • Sun L, Zhang J, Su N, Zhang S, Yan F, Lin X, Yu J, Li W, Li X, Xiao S. Analysis of Genotype-Phenotype Correlations in Patients With Degenerative Dementia Through the Whole Exome Sequencing. Front Aging Neurosci. 2021 Oct 14;13:745407. doi: 10.3389/fnagi.2021.745407. PMID: 34720994; PMCID: PMC8551445. (IF: 5.702)

  • Liu CC#, Murray ME#, Li X#, Zhao N, Wang N, Heckman MG, Shue F, Martens Y, Li Y, Raulin AC, Rosenberg CL, Doss SV, Zhao J, Wren MC, Jia L, Ren Y, Ikezu TC, Lu W, Fu Y, Caulfield T, Trottier ZA, Knight J, Chen Y, Linares C, Wang X, Kurti A, Asmann YW, Wszolek ZK, Smith GE, Vemuri P, Kantarci K, Knopman DS, Lowe VJ, Jack CR Jr, Parisi JE, Ferman TJ, Boeve BF, Graff-Radford NR, Petersen RC, Younkin SG, Fryer JD, Wang H, Han X, Frieden C, Dickson DW, Ross OA, Bu G*. APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia. Sci Transl Med. 2021 Sep 29;13(613):eabc9375. doi: 10.1126/scitranslmed.abc9375. Epub 2021 Sep 29. PMID: 34586832. (IF:19.319)

  • Yang CY, Xu HJ, Liu SS, Wu YJ, Long Y, Liu HS, Chen YP, Li X. Family Dynamics and Grandparents' Anxiety and Depression in Intergenerational Rearing Families: A Correlational Study. Front Psychiatry. 2021 May 20;12:633773. doi: 10.3389/fpsyt.2021.633773. PMID: 34093261; PMCID: PMC8172783. (IF:5.435)

  • Nie J, Qiu Q, Phillips M, Sun L, Yan F, Lin X, Xiao S, Li X. Early Diagnosis of Mild Cognitive Impairment Based on Eye Movement Parameters in an Aging Chinese Population. Front Aging Neurosci. 2020 Jul 29;12:221. doi: 10.3389/fnagi.2020.00221. PMID: 32848703; PMCID: PMC7405864. (IF:4.362)

  • Gao Y, Cui M, Yang C, Wu Y, Long Y, Chen Y, Liu H, Sun L, Yang Y, Li X. Validity and reliability of the Brain Health Self-Efficacy Scale for the elderly. Gen Psychiatr. 2020 Jul 28;33(5):e100208. doi: 10.1136/gpsych-2020-100208. PMID: 32818168; PMCID: PMC7388878.

  • Gao Y, Sun F, Jiang W, Fang Y, Yue L, Lin X, Li X. Beliefs towards the COVID-19 pandemic among patients with emotional disorders in China. Gen Psychiatr. 2020 Jun 9;33(3):e100231. doi: 10.1136/gpsych-2020-100231. PMID: 32574346; PMCID: PMC7287490.

  • Jiang W, Sun F, Prieto L, Fang Y, Gao Y, Yue L, Lin X, Zhao L, Dang J, Qiu J, Li X. Worries, Strategies and Confidence of Older Chinese Adults During the 2019 Novel Coronavirus Outbreak. Int J Geriatr Psychiatry. 2020 Sep 10. doi: 10.1002/gps.5430. PMID: 32909299.(IF:2.675)

  • Wang J, Sun F, Qiu Q, Li Q, Zhang Q, Yang H, Qiu J, Zhu M, Li X. Geriatric psychiatry development in health care settings in mainland China: Challenges and outlook. Int J Geriatr Psychiatry. 2020 Sep;35(9):1078-1079. doi: 10.1002/gps.5317. Epub 2020 May 20. PMID: 32436232. (IF:2.675)

  • Sun L, Cheng B, Zhou Y, Fan Y, Li W, Qiu Q, Fang Y, Xiao S, Zheng H, Li X. ErbB4 Mutation that Decreased NRG1-ErbB4 Signaling Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis/Frontotemporal Dementia. J Alzheimers Dis. 2020;74(2):535-544. doi: 10.3233/JAD-191230. [IF:3.51].

  • Qi Qiu, Xiang Lin, Lin Sun, Min-jie Zhu, Tao Wang, Jing-hua Wang, Guan-jun Li, Shi-fu Xiao* and Xia Li*.Cognitive decline is related to high blood glucose levels in older Chinese adults with the ApoE ε3/ε3 genotype. Translational Neurodegeneration 2019 Apr 3;8:12. (IF:5.534)

  • Li W, Qiu Q, Sun L, Li X, Xiao S. Short-term adverse effects of the apolipoprotein E ε4 allele over language function and executive function in healthy older adults. Neuropsychiatr Dis Treat. 2019 Jul 10;15:1855-1861.

  • Sun Lin†, Yang Yang†, Qiu Qi, Li Wei, Nie Jing, Zhang Jie, Li Xia* and Xiao Shifu*. The Beneficial Effect of Physical Exercise on Cognitive Function in a Non-dementia Aging Chinese Population. Front Aging Neurosci. 2019 Aug 29;11:238.

  • Sun Lin#, Rong Zhouyi, Li Wei, Zheng Honghua, Xiao Shifu, Li Xia*. SQSTM1 nonsense mutation in atypical behavioral variant frontotemporal dementia. Front Aging Neurosci. 2018 Feb 6;10:26. doi: 10.3389/fnagi.2018.00026. (IF:3.63)

  • Yuan Fan#, Qi Qiu, Shengyu Zhang, Lin Sun, Guanjun Li, Shifu Xiao, Xia Li*. Changes in miR-132 and miR-124 levels in non-treated and citalopram-treated patients with depression. Journal of affective disorder, 2018, 227: 745-751(IF:4.08)

  • Sun L#, Xu H#, Zhang J, Li W, Nie J, Qiu Q, Liu Y, Fang Y, Yang Z*, Li X*, Xiao S*. (2018). Alcohol Consumption and Subclinical Findings on Cognitive Function, Biochemical Indexes, and Cortical Anatomy in Cognitively Normal Aging Han Chinese Population. Front Aging Neurosci, 10, 182. doi: 10.3389/fnagi.2018.00182

  • Lin S#, Wei L, Ping Y, Xia L*, Xiao S*. Upregulated BMP6 pathway involved in the pathogenesis of Aβ toxicity in vivo. Neurosci Lett. 2018 Jan 18;664:152-159.

  • Gao Y, Xia L#, Liu XH, Zhao QH, Che XQ, Guo QH, Ren RJ, Wang G. Determining association of rho kinase 1 gene polymorphisms with risk of Alzheimer's disease: a multicenter pilot study. Ann Transl Med. 2018 Nov;6(22):434.doi:10.21037/atm.2018.05.51. PubMed PMID: 30596064; PubMed Central PMCID:PMC6281534. SCI AD IF=3.69

  • Chunxia Ban, Qunying Zhang, Jie Feng, Huijuan Li, Qi Qiu, Yuan Tian* and Xia Li*. Low prevalence of lipid metabolism abnormalities in APOE ε2-genotype and male patients 60 years or older with schizophrenia. BMC psychiatry, 2017, 17(1) :399. DOI 10.1186/s12888-017-1530-9

  • Sun Lin, Li Wei, Yang Ping, Xia Li*, Shifu Xiao*. Upregulated BMP6 pathway involved in the pathogenesis of Ab toxicity in vivo. Neuroscience letter, 2017, 10;664:152-159.

  • Wei Li,Qi Qiu, Lin Sun, Ling Yue , Tao Wang, Xia Li*, Shifu Xiao*. Sex differences in obesity and cognitive function in a cognitively normal aging Chinese Han population. Neuropsychiatric Disease and Treatment. 2017: (Sep-27) 13 2405-2410.

  • Qiu Q, Zhang S, Lin X, Ban C, Yang H, Liu Z, Wang J, Wang T, Xiao S, Abdel-Khalek AM, Li X*. Psychometric Properties of the Chinese Version of the Arabic Scale of Death Anxiety. Shanghai Arch Psychiatry. 2016 Jun 25;28(3):139-146.

  • Zhongyong SHI, Shifu XIAO*, Xia LI*. Treatment resistant depression or dementia: a case report. Shanghai Archives of Psychiatry, 2016, 28(2): 109-113.

  • Chun-Xia Ban, Shi-Fu Xiao, Xiang Lin, Tao Wang, Qi Qiu, Min-Jie Zhu and Xia Li*. Clinicians’ prescription preferences for treating patients with Alzheimer’s disease in Shanghai. Translational neurodegeneration, 2016, 5:8 DOI 10.1186/s40035-016-0055-3

  • Chun-xia Ban, Li Zhong, Tao Wang, Min-jie Zhu, Jing-Hua Wang, Zhen-lian Zhang, Zhe Wang, Ning Su, Yuan-Yuan Liu, Yan-chen Shi, Shi-fu Xiao, Xia Li. Enhanced Diabetes Susceptibility in Community Dwelling Han Elders Carrying theApolipoprotein E 3/3 Genotype. PloS ONE, 2016, Mar 21;11(3):e0151336.

  • Fang Y, Xiao SF, Zhang SY, Qiu Q, Wang T, Li X. Increased Plasma S100β Level in Patients with Major Depressive Disorder. CNS neurosci Ther. 2016,22:248-250.

  • Li X, Fan Y, Xiao S, Peng S, Dong X, Zheng X, Liu CC, Li H, Xiao Z. Decreased platelet 5-hydroxytryptamin (5-HT) levels: a response to antidepressants. J Affect Disord, 2015, 15 (187): 84-90

  • Xia Li,Shifu Xiao, Yuan Fang, Minjie Zhu, Tao Wang, Katrin Seeher, Henry Brodaty. Validation of the general practitioner assessment of cognition-Chinese version (GPCOG-C) in China. International Psychogeriatrics, 2013, 25:10, 1649-1657.

  • Xia Li,Shifu Xiao, Zeping Xiao, et al. A survey in Shanghai communities: the public awareness and attitude about dementia, psychogeriatrics, 2011, 11: 83-89.

  • Wang T, Shi F, Jin Y, Yap PT, Wee CY, Zhang J, Yang C, Li X, Xiao S, Shen D. Multilevel Deficiency of White Matter Connectivity Networks in Alzheimer's Disease: A Diffusion MRI Study with DTI and HARDI Models.Neural Plast. 2016

  • Liu CC, Tsai CW, Deak F, Rogers J, Penuliar M, Sung YM, Maher JN, Fu Y, Li X, Xu H, Estus S, Hoe HS, Fryer JD, Kanekiyo T, Bu G. Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease. Neuron, 2014 1; 84(1):63-77.

  • Atagi Y, Liu CC, Painter MM, Chen XF, Verbeeck C, Zheng H, Li X, Rademarkers R, Kang SS, Xu H, Younkin S, Das P, Fryer JD, Bu G. Applipoprotein E is a ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). J Biol Chem, 2015, 290(43): 26043-50.

  • Sun L, Guo C, Wang T, Li X, Li G, Luo Y, Xiao. LIMK1 is involved in the protective effects of bone morphogenetic protein 6 against amyloid-b-induced neurotoxicity in rat hippocampal neurons. J Alzheimers Dis. 2014, 42 (2): 543-554.

  • Lin Sun, Xia Li, Xiang Lin, Feng Yan, Kathryn Chen, and Shifu Xiao. Familial fatal insomnia with atypical clinical features in a patient with D178N mutation and homozygosity for Met at codon 129 of the prion protein gene. Prion 2015, 9: 228-235

  • Perminder S Sachdev, Darren M Lipnicki, Nicole A Kochan, John D Crawford, Kenneth Rochwood, Shifu Xiao, Juan Li, Xia Li, Carol Brayne, Fiona E Matthew, Bolssom CM Stephan, Richard B Lipton, Mindy J Katz, Karen Ritchie, Isabelle Carriere, Marie-Laure Ancelin, Sudha Seshadri, Rhoda Au, Alexa S Beiser, Linda CW LAM, Candy HY Wong, Ada WT Fung, Ki Woong Kim, Ji Won Han, Tae Hui Kim, Ronald C Petersen, Rosebud O Roberts, Michelle M Mielke, Mary Ganguli, Hiroko H Dodge, Tiffany Hughes, Kaarin J Anstey, Nicolas Cherbuin, Peter Butterworth, Tze Pin Ng, Qi Gao, Simone Reppermund, Henry Brodaty, Kenichi Meguro, Nicole Schupf, Jennifer Manly,Yaakov Stern, Antonio Lobo, Raúl Lopez-Anton, Javier Santabárbara for COSMIC. COSMIC(cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups. BMC Neurology, 2013, 13:165.