Director of Division of Mood Disorders
Institute: Shanghai Mental Health Center
Research: clinical and basic research in mood disorder
Daihui Peng is the Chief Psychiatrist and doctoral supervisor in Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine. He graduated from Fudan University School of Medicine, and visited University of Nottingham in 2010. As a visiting scholar, he studied in University of Nottingham & University of North Carolina at Chapel Hill in 2013-2014. He is an Honorary Vice-Secretary of World Federation of Societies of Biological Psychiatry, the vice-president of Chinese Society of Neuroscience & Psychiatry (CSNP), the Committee Member in Cooperative Study Group of Chinese Depression, the Committee Member in Cooperative Study Group of Chinese Bipolar Disorder, and the Vice President in Society of Medical Psychology, Shanghai Psychological Society. Dr. Peng’s major areas of research interest include neurobiology and treatment of major depressive and bipolar disorder. Dr. Peng have conducted several national epidemiological and clinical intervention programme on mood disorders, including Brain Science and Brain-Like Intelligence Technology, National Natural Science Foundation of China, Shanghai Science and Technology Committee, cross-disciplinary and translational medical research of Shanghai Jiao Tong University etc.
Huifeng Zhang, Zhen Zhou, Lei Ding, Chuangxin Wu, Meihui Qiu, Yueqi Huang, Feng Jin, Liming Hsu, Yao Yang, Ting Shen, Jinhong Wang, Han Zhang, Dinggang Shen*, Daihui Peng* Divergent and convergent imaging markers between bipolar and unipolar depression based on Machine Learning .IEEE Journal of Biomedical and Health Informatics.2022,26(8):4100-4110.
Yun Wang, Xiaohua Liu, Daihui Peng*, Yan Wu, Yun’ai Su, Jia Xu, Xiancang Ma, Yi Li, Jianfei Shi, Xiaojing Cheng, Han Rong, and Yiru Fang*.A Preliminary Randomized Controlled Trial of Different Treatment Regimens for Melancholic Depression. Neuropsychiatric Disease and Treatment, 2021; 17: 2441–2449.
Huifeng Zhang, Zhiguo Wu, Lan Cao, Yousong Su, Fan Wang, Wu Hong, Yiyun Cai, Daihui Peng*, Yiru Fang*. Evaluating the Efficacy and Moderators of Algorithm-Guided Antidepressant Treatments of Major Depressive Disorder. Journal of Affective Disorders, 2022，297：68-75
Yang L, Wu Z, Cao L, Wang Y, Su Y, Huang J, Fang M, Yao Z, Wang Z, Wang F, Zhu Y, Wang Y, Chen J,Peng D*, Fang Y*. Predictors and moderators of quality of life in patients with major depressive disorder: An AGTs-MDD study report. Journal of Psychiatric Research, 2021 Jun;138:96-102.
Shen He, Zhifang Deng, Zhao Li, Wenqi Gao, Duan Zeng, Yue Shi, Nan Zhao, Feikang Xu, Tian Li, Huafang Li*, Daihui Peng*. Signatures of 4 autophagy-related genes as diagnostic markers of MDD and their correlation with immune infiltration.Journal of Affective Disorders, 2021,295:11–20.
Wang X, Wu H, Huang J, Gao C, Yin Y, Tang X*, Peng D*. Reward Mechanism of Depressive Episodes in Bipolar Disorder: Enhanced Theta Power in Feedback-Related Negativity. Journal of Affective Disorders, 2021,292:217-222.
Yao Yang, Meng-Juan Xing, Yuan Li, Hui-Feng Zhang, Ti-Fei Yuan*, Dai-Hui Peng*. Reduced NLRP3 inflammasome expression in the brain is associated with stress resilience,Psychoneuroendocrinology, 2021,128: 105211.
Jia H, Yiwen C, Yousong S, Min Z, Yifan S, Na Z, Feng J, Daihui P*, Yiru F*. Gastrointestinal Symptoms During Depressive Episodes in 3256 Patients with Major Depressive Disorders: Findings from the NSSD. Journal of Affective Disorders, 2021,286:27-32
Huifeng Zhang#, Lena Palaniyappan#, Yan Wu, Enchao Cong, Chuangxin Wu, Lei Ding, Feng Jin, Meihui Qiu, Yueqi Huang, Ye Wu, Jinhong Wang, Shihui Ying⁎, Daihui Peng⁎. The concurrent disturbance of dynamic functional and structural brain connectome in major depressive disorder: the prefronto-insular pathway. Journal of affective disorders, 2020, 274:1084-1090
Meihui Qiu#, Geya Liu#, Huifeng Zhang, Yueqi Huang, Jinhong Wang, Shihui Ying, Ting Shen*, Daihui Peng*. The Insular Subregions Topological Characteristics of Patients With Bipolar Depressive Disorder.Frontiers in Psychiatry,2020,11:253.
Peng D, Wang Z, Xu Y. Challenges and opportunities in mental health services during the COVID-19 pandemic. General Psychiatry 2020;33:e100275.
Yuncheng Zhu#, Zhiguo Wu#, Oliver Sie, Yiyun Cai, Jia Huang, Hongmei Liu, Yamin Yao, Zhiang Niu, Xiaohui Wu, Yifan Shi, Chen Zhang, Tiebang Liu, Han Rong, Haichen Yang, Daihui Peng*, Yiru Fang* Causes of Drug Discontinuation in Patients with Major Depressive Disorder in China. Progress in Neuropsychopharmacology & Biological Psychiatry.2020, 96: 109755
Zhang H#, Qiu M#, Ding L, Mellor D, Li G, Shen T*, Peng D*. Intrinsic gray-matter connectivity of the brain in major depressive disorder. Journal of affective disorders, 2019, 251: 78-85
Zhang H#, Ding L#, Shen T, Peng D*. HMGB1 involved in stress-induced depression and its neuroinflammatory priming role: a systematic review. General Psychiatry, 2019, 32(4): e100084.
Zhang H F#, Mellor D, Peng D H*. Neuroimaging genomic studies in major depressive disorder: a systematic review[J]. CNS neuroscience & therapeutics, 2018, 24(11): 1020-1036
Zhao D#, Wu Z#, Zhang H, Mellor D, Ding L, Wu H, Wu C, Huang J, Hong W, Peng D*, Fang Y*, Somatic symptoms vary in major depressive disorder in China Compr Psychiatry 2018 Aug 28:32-37.
Meihui Qiu #, Huifeng Zhang #, David Mellor, Jun Shi, Chuangxin Wu, Yueqi Huang,Jianye Zhang, Ting Shen * and Daihui Peng *. Aberrant Neural Activity in Patients With Bipolar Depressive Disorder Distinguishing to the Unipolar Depressive Disorder: A Resting-State Functional Magnetic Resonance Imaging Study. Front. Psychiatry 9:238.
Hongye Liu, Lei Ding, Huifeng Zhang, David Mellor, Haiyan Wu, Dongmei Zhao,Chuangxin Wu, Zhiguang Lin, Jiaojian Yuan and Daihui Peng*.The Metabolic Factor Kynurenic Acid of Kynurenine Pathway Predicts Major Depressive Disorder. Front. Psychiatry 2018;9:552.
Shen Ting#, Li Cao, Wang Biao, Yang Wei-min, Zhang Chen, Wu Zhiguo, Qiu Mei-hui, Liu Jun; Xu Yi-feng*, Peng Dai-hui*. Increased Cognition Connectivity Network in Major Depression Disorder: A fMRI Study, Psychiatry Investigation, 2015;12(2): 227-234.
Peng Daihui#, Shi Feng#, Li Gang, Fralick Drew, Shen Ting, Qiu Meihui, Liu Jun, Jiang Kaida, Shen Dinggang*, Fang Yiru*. Surface Vulnerability of Cerebral Cortex to Major Depressive Disorder, Plos One, 2015;10(3): e0120704.
Daihui Peng#, Elizabeth B.Liddle, Sarina J.Iwabuchi, Chen Zhang, Zhiguo Wu, Jun Liu, Kaida Jiang, Lin Xu, Peter F. Liddle, Lena Palaniyappan*,Yiru Fang*. Dissociated large-scale functional connectivity networks of the precuneus in medication-naive first-episode depression, Psychiatry Research-Nueroimaging, 2015; 232(3): 250-256.
Daihui Peng#, Ting Shen, Linda Byrne, Chen Zhang, Yueqi Huang, Xin Yu, Jingping Zhao, Marita McCabe, David Mellor, Yiru Fang*. Atypical features and treatment choices in bipolar disorders: a result of the National Bipolar Mania Pathway Survey in China, Neuroscience Bulletin, 2015; 31(1): 22-30.
Sarina J. Iwabuchi#, Daihui Peng#, Yiru Fang, Kaida Jiang, Elizabeth B. Liddle, Peter F. Liddle, Lena Palaniyappan*. Alterations in effective connectivity anchored on the insula in major depressive disorder, European Neuropsychopharmacology, 2014;24(11): 1784-1792.
Daihui Peng#, Feng Shi, Ting Shen, Ziwen Peng, Chen Zhang, Xiaohua Liu; Meihui Qiu, Jun Liu, Kaida Jiang, Yiru Fang*, Dinggang Shen*. Altered brain network modules induce helplessness in major depressive disorder. Journal of Affective Disorders, 2014;168: 21-29.
Ting Shen#, Meihui Qiu#, Chao Li, Jie Zhang, Zhiguo Wu, Biao Wang, Kaida Jiang, Daihui Peng*, Altered spontaneous neural activity in first-episode, unmedicated patients with major depressive disorder, Neuroreport, 2014; 25(16): 1302-1307.
Wang L, Peng D*, Xie B, Jiang K, Fang Y*. The extracellular signal-regulated kinase pathway may play an important role in mediating antidepressant-stimulated hippocampus neurogenesis in depression. Medical Hypotheses, 2012, 79(1): 87-91.
Peng D#, Shen T, Zhang J, Huang J, Liu J, Liu S, Jiang K, Xu Y*, Fang Y*. Abnormal functional connectivity with mood regulating circuit in unmedicated individual with major depression: a resting-state functional magnetic resonance study. Chinese Medical Journal, 2012, 125(20): 3701-3706.