Ottawa-Shanghai Joint School of Medicine


LIU Chang






Tel: 021-63846590-776431


Liu Chang, Associate Professor in Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine. She received her PhD from Shanghai Jiao Tong University School of Medicine in 2009 in Medical Microbiology and Parasitology. She is a keynote teacher of ‘Microbiology’ in Ottawa-Shanghai Joint School of Medicine and ‘Medical Microbiology and Parasitology in College of Basic Medical Sciences. As the main participant, she won the national online first-class course "Medical Microbiology". Deputy editor of the national planning textbook "Medical Microbiology and Parasitology", and participated in the compilation of the national English planning textbook "Medical Microbiology". She is in charge of the demonstration course of Medical Microbiology in Shanghai. She has won more than 20 teaching awards, such as the first prize of the National Teaching Competition for Young Teachers in Colleges and Universities, the first prize of the National Teaching Competition for Young Teachers in Basic Medicine, the special prize of the Shanghai Teaching Competition for Young Teachers in Colleges and Universities, the Shanghai Teaching Expert, and the Shanghai May Day Labor Medal. In terms of scientific research, she has been engaged in related research on the interaction between human microbiota, probiotics and host, especially focusing on the regulation strategy of the microbiota in colorectal cancer and diabetes. Her studies also focus on the safety assessment of probiotic bacteria, transfer of antimicrobial resistance genes in swine, soil and human interfaces. She has published more than 20 research papers and won NFSC funding support. She also serves as director of Shanghai Society of Food Science, and member of Microecology Special Committee of Shanghai Preventive Medicine Association, and member of Youth Working Committee of Shanghai Society for Microbiology. Member of Shanghai Youth Federation, Executive member of Shanghai Women's Federation, Council member of Shanghai Outstanding Young Female Teachers Association.


  • Jin, LL, Deng L, Mark Bartlett, Ren YP, Lu JH, Chen Q, Pan YX, Wang H, Guo XK, Liu C*, A Novel Herbal Extract Blend Product Prevents Particulate Matters-Induced Inflammation by Improving Gut Microbiota and Maintaining the Integrity of the Intestinal Barrier. Nutrients. 2022 May 11;14(10):10.3390/nu14102010.

  • Cai MF, Pu, BC, Wang Y, Lv L, Jiang CY, Fu XM, Zhang Y, Zhao W, Dong K, Yang Y, Liu YM, Wei YL, Zhang ZY, Li JH, Guo XK, Liu C*, Qin JH*, A Plasmid With Conserved Phage Genes Helps Klebsiella pneumoniae Defend Against the Invasion of Transferable DNA Elements at the Cost of Reduced Virulence. Front Microbiol. 2022 Mar 17;13:827545.

  • Fu, XM, Lyu L, Wang Y, Zhang Y, Guo, XK, Chen Q, Liu, C*., Safety assessment and probiotic characteristics of Enterococcus lactis JDM1. Microb Pathog. 2022 Feb;163:105380.

  • Chen, Q., Ma, X., Li, C., Shen, Y., Zhu, W., Zhang, Y., Guo, X., Zhou, J., and Liu, C*., Enteric Phageome Alterations in Patients With Type 2 Diabetes. Front Cell Infect Microbiol, 2021. 10:p. 575084. * Corresponding author)(Q1 5.293)

  • Chen Q; Ren YP; Lu JH; Mark Bartlett; Chen L; Zhang Y; Guo XK; Liu C *, A Novel Prebiotic Blend Product Prevents Irritable Bowel Syndrome in Mice by Improving Gut Microbiota and Modulating Immune Response, Nutrients, 2017 Dec 9;9(12):1341. ( * Corresponding author)(Q1 4.196)

  • Zhou D, Pan Q, Liu XL, Yang RX, Chen YW,  Liu C*,  Fan JG. Clostridium butyricum B1 alleviates high-fat diet-induced steatohepatitis in mice via enterohepatic immunoregulation. J Gastroenterol Hepatol. 2017 Jan 20.(Q2 3.483)

  • Wei Y, Ye L, Li Y, Yang F, Liu D, Guo X, Tang R, Liu C*. Functional characterization of RelBE toxin-antitoxin system in probiotic Bifidobacterium longum JDM301. Acta Biochim Biophys Sin (Shanghai). 2016  48(8):741-9(* 通讯作者).(Q3 2.20)

  • Wei YX, Ye L, Liu DB, Zhang ZY, Liu C*, Guo XK. Activation of the chromosomally encoded mazEFBif locus of Bifidobacterium longum under acid stress. International Journal of Food Microbiology 2015; 207: 16-22.

  • Liu C, Xu H, Zhang B, Malin E. V. Johansson, Li J, Gunnar C. Hansson, Fayez K Ghishan NHE8 plays an important role in mucosal protection via its effect on bacterial adhesion. Am J Physiol Cell Physiol. 2013. 305(1):C121-128

  • Liu C, Zhang ZY, Dong K, Guo XK Adhesion and immunomodulatory properties of Bifidobacterium lactis HN019 to intestinal epithelial cells INT-407. World Journal of Gastroenterology 2010; 16(18):2283-2290(第一作者)

  • Liu C, Zhang ZY, Dong K, Yuan JP, Guo XK Antibiotic resistance of probiotic strains of lactic acid bacteria isolated from marketing food and drugs. Biomedical and Environmental Science 2009; 22: 401-402

  • Zhou D, Pan Q, Xin FZ, Zhang RN, He CX, Chen GY, Liu C, Chen YW, Fan JG. Sodium butyrate attenuates high-fat diet induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier. World J Gastroenterol. 2017 Jan 7;23(1):60-75.

  • Wei YX, Zhang ZY, Liu C, Pradeep K. Malakar, Guo XK Safety assessment of Bifidobacterium longum JDM301 based on complete genome sequences. World J Gastroenterol 2012 February 7; 18(5): 479-488

  • Zhang ZY, Liu C, Zhu YZ, Wei YX, Tian F, Zhao GP, Guo XK Safety assessment of Lactobacillus plantarum JDM1 based on the complete genome, International Journal of Food Microbiology 2012; 153: 166-170.

  • Zhang ZY, Liu C, Guo XK Complete genome sequence of Lactobacillus plantarum JDM1. J Bacteriol. 2009 Aug; 191(15):5020-5021.

  • Wei YX, Zhang ZY, Liu C, Guo XK Complete Genome Sequence of Bifidobacterium longum JDM301. J Bacteriol 2010 192 (15): 4076-4077

  • Dong K, Li QT, Liu C, Zhang YY, Zhao GP, Guo XK Cloning and Characterization of Three cheB Genes in Leptospira interrogans. Acta Bioch Bioph Sin 2010 42(3):216-22.