School of Pediatrics


Ma Jie



Research Interests:Pediatric brain tumor research


  • 1994-1998Harbin Medical University, Harbin, Province of Heilongjiang, P. R. China , Human medicine, Doctor Degree

  • 1989-1992Harbin Medical University, Harbin, Province of Heilongjiang, P. R. China , Human medicine, Master Degree

Professional Activities & Experience

  • 2006- present  Professor and head of Pediatric Neurosurgical Department Shanghai Jiaotong University Affiliated Xinhua Hospital, P. R. China

  • 2001-2006 Professor and head of Department of Neurosurgery  Shanghai Jiaotong University Affiliated Xinhua Hospital, P. R. China

Research Interests

Brain tumor research

  • Dr.Ma’s research focuses on brain tumor tissue bank and we collected more than 1000 pediatric patients with brain tumors. We have performed large scale genetic screen and successfully identified druggable genes. We focused on chromatin remodeling, epigenetic modifications, DNA methylation profiling and their roles in medulloblastoma metastasis.

Minimal Invasive Image-Guided Neurosurgery and Pediatric Neurosurgery

  • Using of MRI, CT and ultrasound to improve the minimal invasive Neurosurgery


  1. Liu F, Jiang W, Sui Y, Meng W, Hou L, Li T, Li M, Zhang L, Mo J, Wang J, Zhao Y, Zhang L, Ma J, Tang Y. CDK7 inhibition suppresses aberrant hedgehog pathway and overcomes resistance to smoothened antagonists. Proceedings of the National Academy of Sciences. 116(26), 12986-12995. (通讯作者)

  2. Lian H, Wang QH, Zhu CB, Ma J, Jin WL. Deciphering the Epitranscriptome in Cancer. Trends Cancer. 2018 Mar;4(3):207-221.(通讯作者)

  3. Meng W, Wang B, Mao W, Wang J, Zhao Y, Li Q, Zhang C, Tang Y, Ma J. Enhanced efficacy of histone deacetylase inhibitor combined with bromodomain inhibitor in glioblastoma. J Exp Clin Cancer Res. 2018 Oct 1;37(1):241.(通讯作者)

  4. Wang, J., Y. Sui, Q. Li, Y. Zhao, X. Dong, J. Yang, Z. Liang, Y. Han, Y. Tang, and Ma J. 2020. 'Effective inhibition of MYC-amplified group 3 medulloblastoma by FACT-targeted curaxin drug CBL0137', Cell Death Dis, 11: 1029. (通讯作者)

  5. Zhao, Y., F. Jiang, Q. Wang, B. Wang, Y. Han, J. Yang, J. Wang, K. Wang, J. Ao, X. Guo, X. Liang, and Ma J. 2020. 'Cytoplasm protein GFAP magnetic beads construction and application as cell separation target for brain tumors', J Nanobiotechnology, 18: 169. (通讯作者)

  6. Zhao, Y., T. Li, S. Tian, W. Meng, Y. Sui, J. Yang, B. Wang, Z. Liang, H. Zhao, Y. Han, Y. Tang, L. Zhang, and Ma J. 2020. 'Effective Inhibition of MYC-Amplified Group 3 Medulloblastoma Through Targeting EIF4A1', Cancer Manag Res, 12: 12473-85. (通讯作者)

  7. Meng W, Wang J, Wang B, Liu F, Li M, Zhao Y, Zhang C, Li Q, Chen J, Zhang L, Tang Y, Ma J. CDK7 inhibition is a novel therapeutic strategy against GBM both in vitro and in vivo. Cancer Manag Res. 2018 Nov 15;10:5747-5758.(通讯作者)

  8. Meng W, Jiang Y, Ma J. Is the prognostic significance of O6-methylguanine- DNA methyltransferase promoter methylation equally important in glioblastomas of patients from different continents? A systematic review with meta-analysis. Cancer Manag Res. 2017 Sep 20;9:411-425.(通讯作者)

  9. Wang B, Han Y, Wang Q, Ma J. The establishment of Shanghai Pediatric Neurosurgical Society and the 12th Asian Australasian Advanced Course in Pediatric Neurosurgery (12th AAACPN): adventure and opportunity for Chinese pediatric neurosurgeons. Childs Nerv Syst. 2018 Apr;34(4):793-795.(通讯作者)

  10. Zhang C, Meng W, Wang J, Lu Y, Hu G, Hu L, Ma J. Methylation Status of the RIZ1 Gene Promoter in Human Glioma Tissues and Cell Lines. Cell Mol Neurobiol. 2017 Aug;37(6):1021-1027.(通讯作者)