Office Phone: 021-65791316
Expertise: Pediatric Intestinal Failure; Short bowel syndrome; Neonatal nutritional support; Congenital digestive tract anomalies; Clinical Nutrition
Cai Wei, M.D., Chief Physician, Professor, and Doctoral Supervisor. He is the Director of Shanghai Institute of Pediatric Medicine, Director of Shanghai Key Laboratory of Pediatric Digestion and Nutrition, Director of Shanghai Pediatric Rare Disease Diagnosis and Treatment Center, Director of Shanghai Key Pediatric Surgery Clinical Medical Center, Head of National Key Clinical Specialties - Pediatric Surgery, Director of Department of Nutrition, Shanghai Jiaotong University School of Medicine, Director of Clinical Genetics Center of Xinhua Hospital, Shanghai Jiaotong University School of Medicine.
He is a member of the 3rd Director of the Chinese Medical Association's Parenteral and Enteral Nutrition Branch, the 7th and 8th Vice Director of the Chinese Medical Association's Pediatric Surgery Branch, a member of the Standing Committee of the Chinese Medical Association's Parenteral and Enteral Nutrition Branch, the Head of the Pediatric Nutrition Support Group of the Chinese Medical Association's Parenteral and Enteral Nutrition Branch, the Vice President of the Chinese Medical Association's Pediatric Surgeons Branch, the Vice President of the Chinese Nutrition Society, the Director of the Medical Food and Nutrition Support Branch of the Chinese Nutrition Society, and a member of the Chinese Society of Nutrition. The Chinese Society of Nutrition, the Chinese Journal of Pediatric Surgery, the Chinese Journal of Clinical Nutrition, the Journal of Clinical Pediatric Surgery, the Chinese Journal of Pediatric Surgery, the Chinese Journal of Nutrition, the Chinese Society of Nutrition. Journal of Clinical Pediatric Surgery", "Journal of Clinical Pediatrics", "Parenteral and Enteral Nutrition", Associate Editor-in-Chief. He enjoys the special allowance of the State Council.
He was the first to successfully implement intestinal rehabilitation treatment for neonatal short bowel syndrome in China, and presided over the formulation of China's first "Clinical Application Guidelines for Neonatal Nutrition Support". He has presided over 7 national projects such as the National Nature Key Project, published 152 SCI papers as the first author and corresponding author, and edited 10 monographs such as Pediatric Surgery, Neonatal Nutrition, and Pediatric Clinical Nutrition Support, etc. He has won 9 provincial and ministerial awards including the Second Prize of National Science and Technology Progress, the Second Prize of Science and Technology Progress of the Ministry of Education, and the First Prize of Shanghai Science and Technology Progress as the first completer. He has trained more than 50 postgraduates.
He has been awarded the Shanghai Silver Snake Award, the Shanghai New Long March Pioneer, the First Young and Middle-aged Medical Science and Technology Star of the Ministry of Health, the Fifth China Youth Science and Technology Award, the Outstanding Young Teachers of Shanghai Universities, the Outstanding Young Science and Technology Star of Shanghai, the Leading Medical Talents of Shanghai, the Outstanding Subject Leader of Shanghai, the Baosteel Outstanding Teacher Award, the Outstanding Contribution Award of the Chinese Nutrition Society, the National Outstanding Science and Technology Worker, the First National Famous Doctor Many honors such as outstanding construction.
Xiao Y, Liu R, Li X, Gurley EC, Hylemon PB, Lu Y, Zhou H*, Cai W*. Long non-coding RNA H19 contributes to cholangiocyte proliferation and cholestatic liver fibrosis in biliary atresia. Hepatology, 2019 May 7.
Wang L#, Gong Z#, Zhang X#, Zhu F, Liu Y, Jin C, Du X, Xu C, Chen Y, Cai W*, Tian C*, Wu J*. Gut microbial bile acid metabolite skews macrophage polarization and contributes to high-fat diet-induced colonic inflammation. Gut Microbes. 2020 Nov 9;12(1):1-20.
Tian X#, Wang Y#, Lu Y, Wang W, Du J, Chen S, Zhou H, Cai W*, Xiao Y*. Conditional depletion of macrophages ameliorates cholestatic liver injury and fibrosis via lncRNA-H19. Cell Death Dis. 2021 Jun 24;12(7):646.
Zhu F, Wang L, Gong Z, Wang Y, Gao Y, Cai W*, Wu J*. Blockage of NLRP3 inflammasome activation ameliorates acute inflammatory injury and long-term cognitive impairment induced by necrotizing enterocolitis in mice. J Neuroinflammation. 2021 Mar 6;18(1):66.
Lu YJ, Yu WW, Cui MM, Yu XX, Song HL, Bai MR, Wu WJ, Gu BL, Wang J, Cai W*, Chu X*. Association Analysis of Variants of DSCAM and BACE2 With Hirschsprung Disease Susceptibility in Han Chinese and Functional Evaluation in Zebrafish. Front Cell Dev Biol. 2021 May 31;9:641152.
Wang Y*#, Jiang Q#, Chakravarti A, Cai H, Xu Z, Wu W, Gu B, Li L*, Cai W*. MicroRNA-4516-mediated regulation of MAPK10 relies on 3' UTR cis-acting variants and contributes to the altered risk of Hirschsprung disease. J Med Genet. 2020 Sep;57(9):634-642.
Xiao Y#, Wang Y#, Liu Y#, Wang W, Tian X, Chen S, Lu Y, Du J, Cai W*. A nonbile acid farnesoid X receptor agonist tropifexor potently inhibits cholestatic liver injury and fibrosis by modulating the gut-liver axis. Liver Int. 2021 Sep;41(9):2117-2131.
Wang Y#, Jiang Q#, Cai H, Xu Z, Wu W, Gu B, Li L*, Cai W*. Genetic variants in RET, ARHGEF3 and CTNNAL1, and relevant interaction networks, contribute to the risk of Hirschsprung disease. Aging (Albany NY). 2020 Mar 6;12(5):4379-4393.
Bai MR#, Niu WB#, Zhou Y#, Gong YM, Lu YJ, Yu XX, Wei ZL, Wu W, Song HL, Yu WW, Gu BL, Cai W*, Chu X*. Association of common variation in ADD3 and GPC1 with biliary atresia susceptibility. Aging, 2020 Apr 21;12(8):7163-7182.
Zhang T#, Liu Y#, Yan JK*, Cai W*. Early downregulation of P-glycoprotein facilitates bacterial attachment to intestinal epithelial cells and thereby triggers barrier dysfunction in a rodent model of total parenteral nutrition. FASEB J. 2020 Mar;34(3):4670-4683. [IF=5.191]
Yan JK, Zhang T, Dai LN, Gu BL, Zhu J, Yan WH, Cai W*, Wang Y*. CELF1/p53 axis: a sustained anti-proliferative signal leading to villus atrophy under total parenteral nutrition. FASEB Journal, 2019 Mar;33(3):3378-3391.
Liu Y, Gong Z, Zhou J, Yan J, Cai W*. Lin 28A/Occludin axis: An aberrantly activated pathway in intestinal epithelial cells leading to impaired barrier function under total parenteral nutrition. FASEB J. 2021 Feb;35(2):e21189.