School of Global Health



Senior Experimentalist

Office Tel:021-63846590-776428

Research interest: revention and control of important zoonotic Pathogens


Yan Zhang, Graducted from Shanghai Jiao Tong University School of Medicine, is an Senior Experimentalist of School of Global Health, Chinese Centre for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine. She is also Secretary of Lactobacillus Professional Committee, Shanghai Society of Food Science, member of  Shanghai Society for Microbiology and  member of Shanghai Society for parasitology. Zhang’s research focuses on prevention and control of important zoonotic Pathogens. Her lab aims to define prevention and control of important zoonotic Pathogens under one health theory.


  • Cai M, Pu B, Wang Y, Lv L, Jiang C, Fu X, Zhang Y, Zhao W, Dong K, Yang Y, Liu Y, Wei Y, Zhang Z, Li J, Guo X, Liu C*, Qin J*: A Plasmid With Conserved Phage Genes Helps Klebsiella pneumoniae Defend Against the Invasion of Transferable DNA Elements at the Cost of Reduced Virulence. Front Microbiol 2022, 13:827545.

  • Xiaomei Fu, Lin Lyu, Yue Wang, Yan Zhang, Xiaokui Guo, Qian Chen**, Chang Liu *. Safety assessment and probiotic characteristics of Enterococcus lactis JDM1. Microbial Pathogenesis 2022,163:105380.

  • Wang Y, Fan X, Du L, Liu B, Xiao H, Zhang Y, Wu Y, Liu F, Chang YF*, Guo X*, He P*: Scavenger receptor A1 participates in uptake of Leptospira interrogans serovar Autumnalis strain 56606v and inflammation in mouse macrophages. Emerging microbes & infections 2021:1-39.

  • Li T, Lyu L, Zhang Y, Dong K, Li Q*, Guo X*, Zhu Y*: A newly isolated E. thailandicus strain d5B with exclusively antimicrobial activity against C. difficile might be a novel therapy for controlling CDI. Genomics 2021, 113:475-83.

  • Feng T, Leptihn S, Dong K, Loh B,  Zhang Y, Stefan M, Li M, Guo X* and CuiZ*: JD419, a Staphylococcus aureus Phage With a Unique Morphology and Broad Host Range. Frontiers in microbiology 2021, 2021, 12:602902.

  • Li T, Zhang Y, Dong K, Kuo CJ, Li C, Zhu YQ, Qin J, Li QT, Chang YF*, Guo X*, Zhu Y*: Isolation and Characterization of the Novel Phage JD032 and Global Transcriptomic Response during JD032 Infection of Clostridioides difficile Ribotype 078. mSystems 2020, 5.

  • Chen Q#, Ma X#, Li C, Shen Y, Zhu W, Zhang Y, Guo X, Zhou J*, Liu C*: Enteric Phageome Alterations in Patients With Type 2 Diabetes. Frontiers in cellular and infection microbiology 2020, 10:575084.

  • Ding B, Li Q, Guo M, Dong K, Zhang Y, Guo X, Liu Q, Li L*, Cui Z*: Prevention of Dermal Abscess Formation Caused by Staphylococcus aureus Using Phage JD007 in Nude Mice. Frontiers in microbiology 2018, 9:1553.

  • Zeng L#, Wang D#, Hu N, Zhu Q, Chen K, Dong K, Zhang Y, Yao Y*, Guo X*, Chang YF*, Zhu Y*: A Novel Pan-Genome Reverse Vaccinology Approach Employing a Negative-Selection Strategy for Screening Surface-Exposed Antigens against leptospirosis. Frontiers in microbiology 2017, 8:396.

  • Xia B#, Sun L#, Fan X, Xiao H, Zhu Y, Qin J, Cai C, Zhao W, Chang YF, Zhang Y*, Guo X*, He P*: A new model of self-resolving leptospirosis in mice infected with a strain of Leptospira interrogans serovar Autumnalis harboring LPS signaling only through TLR4. Emerging microbes & infections 2017, 6:e36.

  • Guo M, Feng C, Ren J, Zhuang X, Zhang Y, Zhu Y, Dong K, He P, Guo X*, Qin J*: A Novel Antimicrobial Endolysin, LysPA26, against Pseudomonas aeruginosa. Frontiers in microbiology 2017, 8:293.

  • Cui Z, Guo X, Dong K, Zhang Y, Li Q, Zhu Y, Zeng L, Tang R, Li L*: Safety assessment of Staphylococcus phages of the family Myoviridae based on complete genome sequences. Scientific reports 2017, 7:41259.

  • Cui Z*#, Feng T#, Gu F, Li Q, Dong K, Zhang Y, Zhu Y, Han L, Qin J, Guo X*: Characterization and complete genome of the virulent Myoviridae phage JD007 active against a variety of Staphylococcus aureus isolates from different hospitals in Shanghai, China. Virology journal 2017, 14:26.

  • Chen Q, Ren Y, Lu J, Bartlett M, Chen L, Zhang Y, Guo X, Liu C*: A Novel Prebiotic Blend Product Prevents Irritable Bowel Syndrome in Mice by Improving Gut Microbiota and Modulating Immune Response. Nutrients 2017, 9.

  • Zhang Q, Wan H, Huang S, Zhang Y, Wang Y, Guo X, He P*, Zhou M: Critical role of RIG-I-like receptors in inflammation in chronic obstructive pulmonary disease. The clinical respiratory journal 2016, 10:22-31.

  • Wang Y, Ding X, Chen Y, Guo M, Zhang Y, Guo X*, Gu H*: Antibiotic-loaded, silver core-embedded mesoporous silica nanovehicles as a synergistic antibacterial agent for the treatment of drug-resistant infections. Biomaterials 2016, 101:207-16.

  • Zhu W, Wang J, Zhu Y, Tang B, Zhang Y, He P, Zhang Y, Liu B, Guo X*, Zhao G*, Qin J*: Identification of three extra-chromosomal replicons in Leptospira pathogenic strain and development of new shuttle vectors. BMC genomics 2015, 16:90.

  • Zeng LB#, Zhuang XR#, Huang LL, Zhang YY, Chen CY, Dong K, Zhang Y, Cui ZL, Ding XL, Chang YF*, Guo XK*, Zhu YZ*: Comparative subproteome analysis of three representative Leptospira interrogans vaccine strains reveals cross-reactive antigens and novel virulence determinants. Journal of proteomics 2015, 112:27-37.

  • Wang Y, Zhuang X, Zhong Y, Zhang C, Zhang Y, Zeng L, Zhu Y, He P, Dong K, Pal U*, Guo X*, Qin J*: Distribution of Plasmids in Distinct Leptospira Pathogenic Species. PLoS neglected tropical diseases 2015, 9:e0004220.

  • Liu B*, Wang Y*, Guo X*, Zhu W*, Zhang Y*, He P*: Carboxyfluorescein diacetate succinimidyl ester labeling method to study the interaction between Leptospira and macrophages. Journal of microbiological methods 2014, 107:205-13.

  • He P, Deng C, Liu B, Zeng L, Zhao W, Zhang Y, Jiang X, Guo X, Qin J*: Characterization of a bifunctional enzyme with (p)ppGpp-hydrolase/synthase activity in Leptospira interrogans. FEMS microbiology letters 2013, 348:133-42.

  • Zhang Y#, Lou XL#, Yang HL, Guo XK, Zhang XY, He P*, Jiang XC*: Establishment of a leptospirosis model in guinea pigs using an epicutaneous inoculations route. BMC infectious diseases 2012, 12:20.

  • Cui Z, Zhou Y, Li H, Zhang Y, Zhang S, Tang S*, Guo X*: Complex sputum microbial composition in patients with pulmonary tuberculosis. BMC microbiology 2012, 12:276.

  • Zhong Y*, Chang X*, Cao XJ*, Zhang Y, Zheng H, Zhu Y, Cai C, Cui Z, Zhang Y, Li YY, Jiang XG, Zhao GP, Wang S*, Li Y*, Zeng R*, Li X*, Guo XK*: Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601. Cell research 2011, 21:1210-29.