School of Global Health


ZHU Yongzhang



Tel: 021-63846590-776974

研究方向:病原组学和耐药控制 pathogenomics and AMR control

Education/Career Background

  • 2002.09-2007.07

    Tsinghua University & Peking Union Medical College             Ph.D

  • 2007.09-2009.09

    Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine             Postdoc

  • 2011.03-2017.07

    Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine             Associated Professor

  • 2017.08-2019.03

    Institute of antibiotics, Huashan Hospital Affiliated to Fudan University             Associated Professor

  • 2020.06-2020.11

    Pathogen NGS sequencing platform of P3 lab, Guangzhou Customs District Technology Center             Associated Professor

  • 2020.12-Present

    School of Global Health, Shanghai Jiao Tong University School of Medicine             Associated Professor

Further Training History

  • 2014.10-2015.10

    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University

    Genome sequencing and pathogenesis of zoonotic Pathogens

  • 2007.09-2009.07

    Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai

    Whole genome sequencing and comparative genomics of multiple pairs of Chinese Leptospira virulent and attenuated strains

  • 2006.05-2007.03

    Key Lab of Animal Bacteriology, College of Veterinary Medicine, Nanjing Agricultural University

    Screeing novel antigens and diagnostic markers of B.pertussis by Immunoproteomics

Research Grants

Principal investigator

  • National Natural Science Foundation of China

    Title: Virulence evolution mechanism of serovar icterohaemorrhagiae virulent and Virulence-attenuated strains in Pathogenic Leptospira Interrogans

  • Provincial Natural Science Foundation

    Title: Genomic and Proteomic-based novel approach for screening vaccine antigens of Bordetella pertussis

  • Chinese Postdoctoral Science Foundation

    Title: Comparative Genomics of Serovar Autumns hypervirulent and Attenuated strains in Pathogenic Leptospira Interrogans

  • Involved Grant

    5 grants in National Natural Science Foundation of China and 2 in National Prevention and contrlo of major infectious diseases such as AIDS and viral hepatitis;


  • Yongzhang Zhu, Li Shi, Yige Zeng, Dongri Piao, Yingbo Xie, Juan Du, Meng Gao, Wei Gao, Junli Tian, Jun Yue, Min Li, XiaoKui Guo*, Yufeng Yao*, YaoXia Kang*. Key Immunity Characteristics of Diverse Stages of Brucellosis in Rural Population from Inner Mongolia, China. Infect Dis Poverty. 2022 accepted.

  • Cheng Chang, Xinbo Yu,Wennan Guo, ChaoYi Guo, XiaoKui Guo*, QingTian Li*, Zhu YZ* (corresponding author). Bacteriophages-Mediated Control of Biofilm: A Promising New Dawn for the Future. Front Microbiol 2022 Apr 4;13:825828. doi: 10.3389/fmicb.2022.825828.

  • Hongye Wang, Dongshan Yan, Ya Li, Yanfei Gong, Yulin Mai, Bingxiang Li, Xiaoyong Zhu, Xinrui Wan, Liyun Xie, HuaKe Jiang, Min Zhang, Ming Sun*, Yufeng Yao*, Zhu YZ* (corresponding author). Clinical and antibody characteristics reveal diverse signatures of severe and non-severe SARS-CoV-2 patients. Infect Dis Poverty. 2022 Feb 2;11(1):15. doi:10.1186/s40249-022-00940-w.

  • Tinghua Li, Lin Lyu, Yan Zhang, Ke Dong, Qingtian Li*, Xiaokui Guo*, Zhu YZ   *(corresponding author). A newly isolated E. thailandicus strain d5B with exclusively antimicrobial activity against C. difficile might be a novel therapy for controlling CDI.  Genomics 2020 Sep 18;S0888-7543(20)30206-8.

  • Tinghua Li, Yan Zhang, Ke Dong, Chih-Jung Kuo, Chong Li, Yong-Qiang Zhu, Jinhong Qin, Qing-Tian Li, Yung-Fu Chang*, Xiaokui Guo*, Zhu YZ *(corresponding author). Isolation and Characterization of the Novel Phage JD032 and Global Transcriptomic Response during JD032 Infection of Clostridioides difficile Ribotype 078. mSystems 2020 May 5;5(3):e00017-20.

  • Cuicai Zhang, Jianmin Xu, Tinglan Zhang, Haiyan Qiu, Zhenpeng Li, Enmin Zhang, Shijun Li, Yung-Fu Chang, Xiaokui Guo*, Xiugao Jiang*, Zhu YZ *(corresponding author). Genetic Characteristics of Pathogenic Leptospira in wild small animals and livestock in Jiangxi Province, China, 2002-2015. PLOS Neglected Tropical Diseases. June 24,2019 10.1371/journal.pntd.0007513

  • Xu-ming Li, Yao-xia Kang1, Liang Lin, En-Hou Jia, Dong-Ri Piao, Hai Jiang, Cui-Cai Zhang, Jin He, Yung-Fu Chang, Xiao-Kui Guo*, Zhu YZ *(corresponding author). Genomic Characterization Provides New Insights for Detailed Phage-Resistant Mechanism for Brucella abortus. Front. Microbiol, 03 May 2019.

  • Jiayu Wang, Zheng Teng, Wei Chu, Fanghao Fang, Xiaoqing Cui, Xiaokui Guo, Xi Zhang*, Bruce Thorley*, Zhu YZ *(corresponding author). The Emergence and Spread of One Coxsackievirus A16 Genogroup D Novel Recombinant Strain Causing a Clustering HFMD Outbreak in Shanghai, China, 2016. Emerg Microbes Infect. 2018 Jul 18;7(1):131.

  • Jiayu Wang, Zheng Teng, Xiaoqing Cui, Chongshan Li, Hao Pan, Yaxu Zheng, Shenghua Mao, Yuying Yang, Limeng Wu, Xiaokui Guo*, Xi Zhang*, Zhu YZ*(corresponding author).  Epidemiological and Serological Surveillance of Hand-Foot-and-Mouth Disease in Shanghai, China, 2012- 2016.  Emerg   Microbes Infect. 2018 Jan 24;7(1):8.

  • Lingbing Zeng, Dongliang Wang, Niya Hu, Qing Zhu, Kaishen Chen, Ke Dong, Yan Zhang, Yufeng Yao*, XiaoKui Guo*, Yung-Fu Chang*, Zhu YZ*(corresponding author). A novel pan-genomic reverse vaccinology approach employing negative-selection strategy for screening surface-exposed antigens against leptospirosis. Front Microbiol. 2017 Mar 14;8:396.

  • YaoXia Kang, XuMing Li,et al, Yung-Fu Chang*, Guo XK*, Zhu YZ *(corresponding author). Typing Discrepancy between Phenotypic and Molecular Characterization Revealing an Emerging Biovar 9 Variant of Smooth Phage-Resistant B. abortus Strain 8416 in China.  Front Microbiol. 2015 Dec 8;6:1375.

  • Zhang Y, Sun J, et al, Chang YF, Guo X*, Li Q*, Zhu YZ *(corresponding author). First report of two rapid-onset fatal infections caused by a newly emerging hypervirulent K. Pneumonia ST86 strain of serotype K2 in China. Front Microbiol. 2015 Jul 21;6:721.

  • Zhang C, Yang H, et al, Chang YF, Guo X*, Zhu YZ *(co-corresponding author), Jiang X*. Molecular Typing of Pathogenic Leptospira Serogroup Icterohaemorrhagiae Strains Circulating in China during the Past 50 Years. PLoS Negl Trop Dis. 2015 May 19;9(5):e0003762.

  • Zeng LB, Zhuang XR, et al, Guo XK*, Zhu YZ *(corresponding author). Comparative subproteome analysis of three representative Leptospira interrogans vaccine strains reveals cross-reactive antigens and novel virulence determinants. J Proteomics. 2015 Jan 1; 112:27-37.

  • Zhu WN, Huang LL, et al, Zhu YZ *(co-corresponding author), Guo XK*. Isolation and characterization of two novel plasmids from pathogenic Leptospira interrogans serogroup Canicola Serovar Canicola strain Gui44. PLoS Negl Trop Dis. 2014 Aug 21;8(8):e3103  .

  • Huang L, et al, Guo XK, Qin JH, Zhu YZ *(corresponding author).  Re-characterization of an extrachromosomal circular plasmid in the pathogenic Leptospira interrogans serovar Lai strain 56601. Acta Biochim Biophys Sin (Shanghai). 2014 Jul;46(7):605-11.