Research Field: Epigenetic regulation in stem cell, development, and disease
Dr. Lingjie Li is a Principle Investigator of the Department of Histoembryology, Genetics, and Developmental Biology at Shanghai Jiao Tong University School of Medicine. He received his B.Sc. degree in Biotechnology from the Northwest University in China and a Ph.D. in Developmental Biology from the Chinese Academy of Science. In 2010, he became a Postdoctoral Fellow and then a Research Associate at Stanford University School of Medicine, where he worked in epigenomics and stem cell regenerative medicine. In late 2019, Dr. Li accepted the faculty position at Shanghai Jiao Tong University and started his independent research laboratory in 2020. His lab has been studying the epigenetic regulation in stem cell, development, and disease.
Scientific Research Projects
Epigenomic regulation of epithelial tissue development
Mechanism of early ectodermal differentiation and development
Skin tissue homeostasis and related disease
Stem cell-based regenerative medicine
Li L, Wang Y, Torkelson JL, Shankar G, Pattison J, H Zhen, Duren Z, Fang F, Melo S, Piekos S, Li J, Liaw E,Chen L, Li R, Wernig M, Wong WH, Chang HY, Oro AE. TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment. Cell Stem Cell. 2019 24:271-284.
Li L, Chang HY. Physiological roles of long noncoding RNAs: insight from knockout mice. Trends in Cell Biology. 2014 24(10): 594-602.
Li L, Liu B, Wapinski OL, Tsai MC, Qu K, Zhang J, Carlson JC, Lin M, Fang F, Gupta RA, Helms JA, Chang HY. Targeted disruption of Hotair leads to homeotic transformation and gene derepression. Cell Reports. 2013 5(1): 3-12.
Li L, Sun L, Gao F, Jiang J, Yang Y, Li C, Gu J, Wei Z, Yang A, Lu R, Ma Y, Tang F, Won Kwon S, Zhao Y, Li J, Jin Y. Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation. PNAS. 2010 107(4): 1402-1407.