College of Basic Medical Sciences


ZENG Fanyi


Tel: 63846590-776667

Research Field:

Personal Introduction

  • Professor Zeng received her MD/PhD degrees and her postdoctoral training from the University of Pennsylvania, School of Medicine. She is currently a Principal Investigator in the Department of Histo-Embryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, and Distinguished Professor of Shanghai Jiao Tong University and School of Medicine.

  • She has been a Changjiang Scholar and a chief scientist of the National Basic Research Program of China (973 Program), as well as recipient of the National Science Fund for Distinguished Young Scholars. She also serves as secretary-general of the International Stem Cell Foundation (ISCF).  Prof. Zeng’s research interests include human genetics and developmental biology, particularly diagnosis and treatment of common genetic diseases, stem cell biology, and preimplantation development.  Prof. Zeng has published in top scientific journals such as Nature, PNAS, Blood, and has been recognized with many scientific awards, such as the First Young Woman Scientist Award by the Third World Organization of Women in Science (TWOWS), the 10th China Youth Science and Technology Award, the 5th C.C. Tan Bioscience Innovation Award, and the second prize of the National Prize for Natural Sciences.

Scientific Research Projects

  • National Key Research and Development Program of China: Cellular molecular regulation mechanism during germ layer formation 2019.12-2024.11

  • National Natural Science Foundation of China: Epigenetic mechanism on reprogramming in cloned cattle 2019.1-2022.12

  • Shanghai key clinical specialty project: Birth defects 2017.9 - 2022. 8

  • The National Basic Research Program of China (973 Program): Mechanism on Differentiation of pluripotent stem cells into mesodermal cells 2014.1- 2018.8


  • Shao-Qing Zhang1, Xiu-Li Gong1, Yi-Ye Zhou1, Qingwen Ma, Qin Cai, Guan-Heng Yang,  Xin-Bing Guo, Yan-Wen Chen, Miao Xu, Yi-Wen Zhu, Yitao Zeng, Fanyi Zeng#. Maternal Prkce expression in mature oocytes is critical for the first cleavage facilitating maternal-to-zygotic transition in mouse early embryos. Cell Prolif.  2022 May 18;e13231

  • Dan Lu, Xiuli Gong, Yudan Fang, Xinbing Guo, Yanwen Chen, Fan Yang, Guijun Zhao, Qingwen Ma, Yitao Zeng, Fanyi Zeng#. Correction of RNA splicing defect in β654-thalassemia mice using CRISPR/Cas9 gene-editing technology. Haematologica. 2022 Jun 1;107(6):1427-1437.

  • Yudan Fang, Yan Cheng, Dan Lu, Xiuli Gong, Guanheng Yang, Zhijuan Gong, Yiwen Zhu, Xiao Sang, Shuyue Fan, Jingzhi Zhang, Fanyi Zeng#. Treatment of β654-thalassaemia by TALENs in a mouse model. Cell Prolif. 2018. 51(6): e12491

  • Jingzhi Zhang, Jingbin Yan, Fanyi Zeng#. Recent Progress on Genetic Diagnosis and Therapy for β-Thalassemia in China and Around the World. Hum Gene Ther. 2018. 29(2): 197-203

  • Xiaoshuang Yan, Yan xue, Yiye Zhou, Yan Cheng, Shang Yinm Qingwen Ma, Fanyi Zeng#. Activation of proHGF by St14 induces mouse embryonic stem cell differentiation. Protein & Cell, 2016. 7: 601-605.

  • Jinbin Yan, Rong Zhang, Can Xiong, Cheng Hu, Yao Lv, Congrong Wang, Weiping Jia, Fanyi Zeng#. Pyrosequencing Is Accurate and Reliable Method for the analysis of Heteroplasmy of the A3243G Mutation in patients with Mitochondrial diabetes. J Mol Diagn. 2014.16(4): 431-9

  • Guanheng Yang, Wansheng Shi, Xingyin Hu, Jingzhi Zhang, Zhijuan Gong, Xinbing Guo, Zhaorui Ren, Fanyi Zeng#. Therapeutic effects of induced pluripotent stem cells in chimeric mice with β-thalassemia. Haematologica, 2014. 99(8): 1304-1311.

  • Fanyi Zeng#, Shu-Zhen Huang, Zhi-Juan Gong, Mei-Jue Chen, Don A Baldwin, Wei Hu, Hui Qian, Jing-bin Yan, Juan Wang, Yan Ping Xiao, Yves Chalandon, Ashley Ringrose, Zhao-Rui Ren, Allen Eaves, Connie Eaves and Xiaoyan Jiang#. Long-term deregulated human hematopoiesis in goats transplanted in utero with BCR-ABL-transduced lin−CD34+ cord blood cells. Cell Res, 2013. 23:859-862. (#corresponding authors)

  • Linlin Wang, Yan Xue, Yihang Shen, Wei Li, Yan Cheng, Xiaoshuang Yan, Wansheng Shi, Juan Wang, Zhijuan Gong, Guanheng Yang, Chuanliang Guo, Yiye Zhou, Xiang Wang, Qi Zhou, Fanyi Zeng#. Claudin 6: a novel surface marker for characterizing mouse pluripotent stem cells. Cell Res, 2012. 22(6): 1082-1085.

  • Zhijuan Gong, Yiye Zhou, Miao Xu, Qin Cai, Hua Li, Jinbin Yan, Juan Wang, Huijun Zhang, Shuyue Fan, Q. Yuan, Shuzhen Huang#, Fanyi Zeng#. Aberrant expression of imprinted genes and their regulatory network in cloned cattle. Theriogenology, 2012. 78: 858-866.

  • Xiaoyang Zhao, Weili, Zhuo Lv, Lei Liu, Man Tong, Tang Hai, Jie Hao, Changlong Guo, Qingwen Ma,Liu Wang, Fanyi Zeng#, Qi Zhou#. iPS cells produce viable mice through tetraploid complementation. Nature, 2009. 461(7260): 86-90. (#corresponding authors)

  • Fanyi Zeng, Meijun Chen, Don A Baldwin, Zhijuan Gong, Jingbin Yan, Hui Qian, Juan Wang, Xiaoyan Jiang, Zhao-rui Ren, Deming Sun, Shu-zhen Huang. Multiorgan engraftment and differentiation of human cord blood CD34(+)Lin(-) cells in goats assessed by gene expression profiling. Proc Natl Acad Sci, 2006. 103(20): 7801-7806.

  • Fanyi Zeng, Richard M Schultz. RNA transcript profiling during zygotic gene activation in the preimplantation mouse embryo. Dev Biol, 2005. 283(1): 40-57

  • Fanyi Zeng. Nobel Prizes and Life Sciences (Chinese Translation Book). Shanghai science and technology publishing house, China, 2021.6

  • Fanyi Zeng and Baosheng Zhu. Medical Genetics. Science Press, Beijing, China, 2020.11

  • Fanyi Zeng and Zhanxiang Shi. The art of translational medicine: Lasker awards and winners (Chinese Translation Book). Shanghai science and technology publishing house, China, 2013.8