College of Basic Medical Sciences

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ZEYU Xiao

Email: xiaozeyu@shsmu.edu.cn

Tel: 63846590-776415

Research Field: Visualized Drug Delivery

Personal Introduction

  • Prof. Zeyu Xiao is a professor and doctoral supervisor in Shanghai Jiao Tong University School of Medicine. She obtained her B.S. in pharmacy from Peking University in 2003. She got her Ph.D. degree in Chemistry from the joint research between Institute of Chemistry, Chinese Academy of Science and University of Florida in 2008. She pursued her postdoctoral training with Prof. Robert Langer and Prof. Omid Farokhzad in MIT-Harvard Center of Cancer Nanotechnology Excellence during 2009~2014. She started her independent career as a Professor in Shanghai Jiao Tong University School of Medicine from 2015. Her scientific research has been focused on drug delivery and molecular imaging. She has published ~40 scientific papers in Chem. Soc. Rev., Nature Communications, Angew. Chem., Advanced Functional Materials, Nano Letters, ACS Nano, PNAS, Small, Biomaterials, Anal Chem, with citations by > 6000 times, and three Book Chapters. Among them, there has been 1 article cited more than 1000 times, 5 articles cited more than 200 times, 7 articles cited more than 100 times, and 3 articles selected as the highly cited papers by ESI. Her scientific achievement has been honored by some prestigious awards in China and U.S.A, including 1000-young talent programs award (2014), Shanghai “Eastern Scholar” Professor Award (2014), Harvard Chinese Life Science Distinguished Research Award, Harvard Medical School (2013), Women in Cancer Research Scholar Award, American Association for Cancer Research (2011). As principle investigator, she has chaired one sub-project of National Key R & D program of China and five projects of National Natural Science Foundation of China.

Scientific Research Projects

  • International (regional) cooperation and exchange program of National Natural Science Foundation of China, Functional modular photodynamic drugs for overcoming bypass activated drug resistance and sequential efficacy monitoring in non-small cell lung cancer, 2022.01~2024.12, ¥ 1,800,000, Principle investigator.

  • National Key Research and Development Program of China, Dynamic visualization of multi-mode programmable nano-drugs in vivo, 2020.11~2025.10, ¥2,120,000, Principle investigator.

  • Cooperation project of basic clinical collaborative research center of Renji Hospital Affiliated to Shanghai Jiao Tong University Medical School, Molecular imaging and drug delivery, 2018.11~2023.11, ¥3,000,000, Principle investigator.

  • National Natural Science Foundation of China, A para-aminothiophenol radical reaction-functionalized SERS nanoprobe for medical analysis of ROS-related diseases, 2019.01~2022.12, ¥640,000, Principle investigator.

  • National Natural Science Foundation of China, Observating 3-D biodistribution and targeting recognition of aptamer-functionalized nanodelivery systems in transparent organs, 2017.01~2020.12, ¥620,000, Principle investigator.

  • National Natural Science Foundation of China, XEO2mini aptamer targted,DNA self-assembled theranostic nanosystem for intraoperative imaging-guided prostate tumor ablation, 2015.01~2018.12, ¥730,000, Principle investigator.

  • National Natural Science Foundation of China, Emergency management project, Prenatal diagnosis of fetal lung development and abnormality using SP-A aptamer-functionalized Raman nanoprobes, 2018.01~2018.12, ¥200,000, Principle investigator.

  • The Thousand Youth Talents Program of China, 2015.01~2019.12, ¥2,000,000, Principle investigator.

  • Project for Shanghai Oriental Scholar Distinguished Professor, 2015.01~2017.12, ¥1,000,000, PI.

  • National Key Research and Development Program of China, Research and development for field rapid detection equipment and reagents of novel coronavirus (2019-nCov) nucleic acid, 2020.01~2020.04, ¥1,000,000, Academic backbone.

  • Medical-engineering cross fund of Shanghai Jiaotong University, The simple home self-examination technique and kit of novel coronavirus infection, 2020.02~2021.01, ¥1,000,000, Academic backbone.

Publications

  • Zhang Y, Cui Y, Li M, Cui K, Li R, Xie W, Liu L, Xiao Z*(Corresponding Author). DNA-assembled visible nanodandelions with explosive hydrogen-bond breakage achieving uniform intra-tumor distribution (UITD)-guided photothermal therapy. Biomaterials 2022, 282, 121381.

  • Cui K, Zhang Y, Chen G, Cui Y, Wu W, Zhao N, Liu T, Xiao Z*(Corresponding Author). Molecular regulation of polymeric Raman probes for ultrasensitive microtumor diagnosis and noninvasive microvessle imaging. Small 2022, 2106925.

  • Xia F, He A, Zhao H, Sun Y, Duan Q, Abbas S J, Liu J*, Xiao Z*(Corresponding Author), Tan W*. Molecular Engineering of Aptamer Self-assemblies Increases in Vivo Stability and Targeted Recognition. ACS Nano 2022,16,1,169-179.

  • Fan C, Zhao N, Cui K, Chen G, Chen Y, Wu W, Li Q, Cui Y, Li R, Xiao Z*(Corresponding Author). Ultrasensitive Exosome Detection by Modularized SERS Labeling for Postoperative Recurrence Surveillance. ACS Sens. 2021 6(9):3234-3241.

  • Gao S, Yu S, Zhang Y, Wu A, Zhang S, Wei G, Wang H*, Xiao Z*(Corresponding Author), Lu W*. Molecular engineering of near-Infrared-II photosensitizers with steric-hindrance effect for image-guided cancer photodynamic therapy. Adv. Func. Mater. 2021, 31(14), 2008356.

  • Zhao N, Chen Y, Chen G, Xiao Z*(Corresponding Author). Artificial cells based on DNA nanotechnology. ACS Applied Bio Materials 2020,3,7,3928-3934.

  • Gao S, Wei G, Zhang S, Zheng B, Xu J, Chen G, Li M, Song S, Fu W, Xiao Z*(Corresponding Author), Lu W* Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics. Nat Commun. 2019,10(1):2206.

  • Gu X, Qiu Y, Lin M, Cui K, Chen G, Chen Y, Fan C, Zhang Y, Xu L, Chen H, Wan JB, Lu W*, Xiao Z*(Corresponding Author). CuS Nanoparticles as a Photodynamic Nanoswitch for Abrogating Bypass Signaling To Overcome Gefitinib Resistance. Nano Lett. 2019,19(5):3344-3352.

  • Qiu Y, Lin M, Chen G, Fan C, Li M, Gu X, Cong S, Zhao Z, Fu L, Fang X*, Xiao Z*(Corresponding Author). Photodegradabl CuS SERS probes for intraoperative residual tumor detection, ablation and self-clearance. ACS Appl Mater Interfaces 2019, 11(26):23436-23444.

  • Zheng B, Xu J, Chen G, Zhang S, Xiao Z*(Corresponding Author), Lu W*. Bacterium-Mimicking Vector with Enhanced Adjuvanticity for Cancer Immunotherapy and Minimized Toxicity. Adv. Func. Mater. 2019, 29(33):1901437.

  • Wu W, Xiao Z*(Corresponding Author). A deep learning “ticket” for single-molecule analysis of protein stoichiometry. Sci China Chem 2019. 62(10): 1269-1270.

  • Xu J, Yu S, Wang X, Qian Y, Wu W, Zhang S, Zheng B, Wei G, Gao S, Cao Z, Fu W, Xiao Z*(Corresponding Author), Lu W*. High Affinity of Chlorin e6 to Immunoglobulin G for Intraoperative Fluorescence Image-Guided Cancer Photodynamic and Checkpoint Blockade Therapy. ACS Nano 2019, 13,10242-10260.

  • Qiu Y, Zhang Y, Li M, Chen G, Fan C, Cui K, Wan J, Han A, Ye J*, Xiao Z*(Corresponding Author) Intraoperative detection and eradication of residual microtumors with gap-enhanced Raman tags. ACS Nano 2018, 12(8):7974-7985.

  • Cui K, Fan C, Chen G, Qiu Y, Li M, Lin M, Wan JB, Cai C, Xiao Z*(Corresponding Author). para-Aminothiophenol Radical Reaction-Functionalized Gold Nanoprobe for One-to-All Detection of Five Reactive Oxygen Species in Vivo. Anal Chem. 2018, 90, 12137-12144.

  • Li M, Qiu Y, Fan C, Cui K, Zhang Y, Xiao Z*(Corresponding Author) Design of SERS nanoprobes for Raman imaging: materials, critical factors and architectures. Acta Pharm Sin B. 2018, 8(3):381-389.

  • Qi Q, Lu L, Li H, Yuan Z, Chen GX, Lin M, Ruan Z, Ye X*, Xiao Z* (Corresponding Author), Zhao Q* Spatiotemporal delivery of nanoformulated liraglutide for cardiac regeneration after myocardial infarction. Int J Nanomedicine 2017, 12:4835-4848.

  • Zhang Y, Qiu Y, Lin L, Gu H, Xiao Z*(Corresponding Author), Ye J* Ultraphotostable Mesoporous Silica-Coated Gap-Enhanced Raman Tags (GERTs) for High-Speed Bioimaging. ACS Appl Mater Interfaces 2017, 9(4):3995-4005.

  • Lu L, Chen G, Qiu Y, Li M, Liu D, Hu D, Gu X, Xiao Z*(Corresponding Author) Nanoparticle-based oral delivery systems for colon targeting: principles and design strategies. Sci Bull 2016, 61(9):670-681.

  • Xiao Z*(Corresponding Author) CuS Nanoparticles: clinically-translational materials for photothermal therapy. Nanomedicine, 2014, 9(3),373-375.

  • Wu J, Kamaly N, Shi J, Zhao L, Xiao Z, Hollett G, John R, Ray S, Xu X, Zhang X, Kantoff PW et al. Development of multinuclear polymeric nanoparticles as robust protein nanocarriers. Angew Chem Int Ed Engl 2014, 53(34):8975-8979.

  • Xiao Z, Levy-Nissenbaum E, Alex F, Luptak A, Teply B, Chan J, Shi J, Diggar E, Cheng J, Langer R, et al. Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection. ACS Nano 2012, 6 (1), 696-704.

Highlighted in ACS Nano (in Nano 2012, volume 6, issue1) and Chemical &Engineering News

“Getting Cancer Cells to Swallow Poison” in ~30 media, such as Science Daily, Medical News Today, NanoWerk

  • Xiao Z, Ji C, Shi J, Pridgen E, Frieder J, Wu J, Farokhzad OC. DNA self-assembly of targeted near infrared-responsive gold nanoparticles for cancer thermo-chemotherapy. Angew Chem Int Ed Engl 2012, 51(47):11853-11857.

  • “First-Of-Its-Kind Self-Assembled Nanoparticle for Targeted and Triggered Thermo-Chemotherapy” in ~ 30 media, including Science Daily, Medical News Today, NanoWerk

  • Xiao Z, Farokhzad OC, Aptamer-functionalized nanoparticles for medical applications: challenges and opportunities. ACS Nano 2012, 6(5), 3670-3676.

  • Kamaly N*, Xiao Z*(Co-First Author), Valencia PM, Radovic-Moreno AF, Farokhzad OC. Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. Chem Soc Rev 2012, 41(7), 2971-3010.

  • Gao W, Xiao Z, Radovic-Moreno A, Shi J, Langer R, Farokhzad OC.  Progress in siRNA Delivery: A Multifunctional Approach by Polymeric Nanoparticles. Methods in Mol Biol 2010, 629, 53-67

  • Shi J, Xiao Z, Votruba AR, Viols C, Farokhzad OC. Differently Charged Hollow Core/shell Lipid-polymer-lipid Hybrid Nanoparticles for Small Interfering RNA Delivery. Angew Chem Int Ed Engl 2011, 50, 7027-7031.

  • Shi J, Xiao Z, Kamaly N, Farokhzad OC. Self-assembled Targeted Nanoparticles: Evolution of Technologies and Bench to Bedside Translation. Acc Chem Res 2011, 44, 1123-34.

  • Liu Q, Chen B, Wang Q, Shi X, Xiao Z, Lin J, Fang X. Carbon Nanotubes as Molecular Tansporters for Walled Plant Cells. Nano Lett 2009, 9(3), 1007-1010.

  • Zhang W, Jiang Y, Wang Q, Ma X, Xiao Z, Zuo W, Fang X, Chen Y. Single Molecule Imaging Reveals Transforming Growth Factor-β-induced Type II Receptor Dimerization. Proc Natl Acad Sci U S A 2009,106(37):15679-15683.

  • Xiao Z, Shangguan D, Cao ZC, Fang X, Tan W. Cell-specific Internalization Study of an Aptamer from Whole Cell Selection. Chemistry 2008, 14, 1769-1775.

  • Xiao Z, Zhang W, Yang Y, Xu L, Fang X. Single-molecule diffusion study of activated EGFR implicates its endocytic pathway. Biochem Biophys Res Commun 2008, 369, 730-734.

  • Xiao Z, Ma X, Jiang Y, Liao J, Yue J, Fang X. Single-Molecule Study of Lateral Mobility of Epidermal Growth Factor Receptor 2/HER2 on Activation. J Phys Chem B 2008, 112, 4140-4145.

  • Shangguan D, Meng L, Cao Z, Xiao Z, Fang X, Li Y, Cardona D, Witek RP, Liu C, Tan W. Identification of Liver Cancer-Specific Aptamers Using Whole Live Cells. Anal Chem 2008, 80(3), 721-728.

  • Yang R, Jin J, Chen Y, Shao N, Kang H, Xiao Z, Tang Z, Wu Y, Zhu Z, Tan W. Carbon Nanotube-Quenched Fluorescent Oligonucleotides: Probes that Fluoresce upon Hybridization. J.Am.Chem.Soc 2008, 130, 8351–8358.

  • Shangguan D, Tang Z, Mallikaratchy P, Xiao Z, Tan W. Optimization and Modifications of Aptamers Selected from Live Cancer Cell Lines. Chembiochem 2007,8,603-606.

  • 36. Ma X, Wang Q, Jiang Y, Xiao Z, Fang X, Chen Y. Lateral Diffusion of TGF-ß Type I Receptor Studied by Single-Molecule Imaging. Biochem Biophys Res Commun 2007,356, 67–71.

  • Xu W, Xiao Z, Zhang T. Mechanical Properties of Silicone Elastomer on Temperature in Biomedical Application. Materials Letters 2005, 59(17), 2153-2155.

Book Chapters:

  • Qiu Y, Lu L, Hu D, Xiao Z* (Corresponding Author) Copper Sulfide nanoparticles: from synthesis to biomedical applications. Nano Based Drug Delivery, IAPC Publishing, 2015, 516-534, ISBN 978-953-56942-2-9

  • Guo L, Li Y, Xiao Z, Lu W. Photothermal Properties of Hollow Gold Nanostructures for Cancer Theranostics. Handbook of Nanomaterials Properties, Springer-Verlag Berlin Heidelberg 2014, ISBN 978-3-642-31107-9_50

  • Xiao Z, Frieder J, Teply B, Langer R, Farokhzad OC Aptamer conjugates: emerging delivery platforms for targeted cancer therapy. Drug Delivery in Oncology: From Basic Research to Cancer Therapy, Wiley-VCH, 2011, 1690 p., Hardcover, ISBN-13: 978-3-527-32823-9

Patent

  • Shi J, Xiao Z, Vilos C, Votruba, A, Langer R, Farokhzad OC. Lipid-polymer hybrid particles. PCT/US2011/050334

  • Xiao Z, Lu L, Chen G, Lin M. Orally colon-targeted drug delivery systems. PCT/CN2016/106175

  • Xiao Z,Lin M,Cui K. Reactive oxygen responsive polymers, carriers and applications 201811592907.6