Research Field: Smart Drug Delivery System for Cancer Therapy
Prof. Chao Fang obtained his Ph.D. in Pharmaceutics from Fudan University in 2005 and is now working as a principal investigator at Shanghai Jiao Tong University School of Medicine. He has published > 50 peer-review scientific papers with citation by >2000 times. He is the project leader of six National Natural Science Foundation of China, and has been honored as Shanghai Award for Shu Guang Scholar, Shanghai Award for Pujiang Talent, and Shanghai Award for Rising Star, Shanghai Silver Snake Award, Youth Pharmaceutical Award (Chinese Pharmaceutical Association), and Sanofi Youth Biopharmaceutical Award (Chinese Pharmaceutical Association).
Lai X, Liu XL, Pan H, Zhu MH, Long M, Yuan Y, Zhang Z, Dong X, Lu Q, Sun P, Lovell JF, Chen HZ, Fang C*. Light-Triggered Efficient Sequential Drug Delivery of Biomimetic Nanosystem for Multimodal Chemo-, Antiangiogenic, and Anti-MDSC Therapy in Melanoma. Adv Mater, 2022, 34(10): 2106682.
Liu XL, Dong X, Yang SC, Lai X, Liu HJ, Gao Y, Feng HY, Zhu MH, Yuan Y, Lu Q, Lovell JF, Chen HZ*, Fang C*. Biomimetic Liposomal Nanoplatinum for Targeted Cancer Chemophototherapy. Adv Sci, 2021, 8(8): 2003679. (Front Cover)
Dong X#, Mu LL#, Liu XL, Zhu H, Yang SC, Lai X, Liu HJ, Feng HY, Lu Q, Zhou BBS, Chen HZ, Chen GQ, Lovell JF, Hong DL*, Fang C*. Biomimetic, Hypoxia-Responsive Nanoparticles Overcome Residual Chemoresistant Leukemic Cells with Co-Targeting of Therapy-Induced Bone Marrow Niches. Adv Funct Mater, 2020, 30(12): 2000309.
Chen ZJ#, Yang SC#, Liu XL, Gao Y, Dong X, Lai X, Zhu MH, Feng HY, Zhu XD, Lu Q, Zhao M, Chen HZ, Lovell JF*, Fang C*. Nanobowl-Supported Liposomes Improve Drug Loading and Delivery. Nano Lett, 2020, 20(6): 4177-4187. (Editors’ Choice)
Gao Y#, Yang SC#, Zhu MH#, Zhu XD, Luan X, Liu XL, Lai X, Yuan Y, Lu Q, Sun P, Lovell JF, Chen HZ*, Fang C*. Metal Phenolic Network-Integrated Multistage Nanosystem for Enhanced Drug Delivery to Solid Tumors. Small, 2021, 17(29): 2100789.
Gong Y#, Liu Z#, Yuan Y#, Yang Z#, Zhang J, Lu Q, Wang W, Fang C*, Lin H*, Liu S*. PUMILIO Proteins Promote Colorectal Cancer Growth via Suppressing p21. Nat Commun, 2022, 13(1):1627.
Feng HY#, Yuan Y#, Zhang Y, Liu HJ, Dong X, Yang SC, Liu XL, Lai X, Zhu MH, Wang J, Lu Q, Lin Q, Chen HZ, Lovell JF, Sun P*, Fang C*. Targeted Micellar Phthalocyanine for Lymph Node Metastasis Homing and Photothermal Therapy in an Orthotopic Colorectal Tumor Model. Nano-Micro Lett, 2021, 13:145. (Cover Story)
Dong X, Liu HJ, Feng HY, Yang SC, Liu XL, Lai X, Lu Q, Lovell JF, Chen HZ, Fang C*. Enhanced Drug Delivery by Nanoscale Integration of a Nitric Oxide Donor To Induce Tumor Collagen Depletion. Nano Lett, 2019, 19(2):997-1008.
Luan X#, Guan YY#, Liu HJ, Lu Q, Zhao M, Sun D, Lovell JF, Sun P, Chen HZ*, Fang C*. A Tumor Vascular-Targeted Interlocking Trimodal Nanosystem that Induces and Exploits Hypoxia. Adv Sci, 2018, 5(8):1800034. (Frontispiece Cover)
Liu HJ, Luan X, Feng HY, Dong X, Yang SC, Chen ZJ, Cai QY, Lu Q, Zhang Y, Sun P, Zhao M*, Chen HZ, Lovell JF, Fang C*. Integrated Combination Treatment Using a “Smart” Chemotherapy and MicroRNA Delivery System Improves Outcomes in an Orthotopic Colorectal Cancer Model. Adv Funct Mater, 2018, 28(28):1801118. (Back Cover)