Research Field: Infection and Immunity
Dr. Zhaojun Wang is a Professor in the Department of Microbiology and Immunology in Shanghai Jiao Tong University School of Medicine, Zhiyuan Honors Teaching Faculty in Shanghai Jiao Tong University, Principle investigator in Shanghai Institute of Immunology.
Dr. Wang obtained her B.Med in Medical Laboratory Science and M.Sc in Microbiology at Shanghai Second Medical University. She received her Ph.D. degree in Immunology from Shanghai Jiao Tong University in 2006. In 2008, Dr. Wang became a Postdoctoral Researcher in the Department of Pathology and Laboratory Science, University of Pennsylvania School of Medicine and returned to Shanghai Jiao Tong University School of Medicine in 2012
Dr. Wang is an expert in the research of infectious diseases. She works in immune responses during infection. In particularly, she is interested in the regulation of innate immune responses and immunopathology mechanism of parasitic diseases. She has published more than 40 original research articles in peer-reviewed journals and more than 10 academic book chapters. She has been a principal investigator for 5 national research projects. Dr. Wang is editorial board members of Chinese Journal of Parasitology and Parasitic Diseases and Journal of Tropical Medicine. She serves as the member of Medical Parasitology Committee, Chinese Preventive Medicine Association.
As a Principle Teacher and Course Leader, Dr. Wang is response for Foundation of Diseases, Medical Microbiology and Parasitology courses for undergraduate and graduate students.
As Vice Director for Faculty Development Department of Shanghai Jiao Tong University School of Medicine. She focuses on assisting faculty and postdoctoral researcher with their professional development.
Hu W*, Yan Q*, Shen DK*, Liu F, Zhu ZD, Song HD, Xu XR, Wang ZJ, Rong YP, Zeng LC, Wu J, Zhang X, Wang JJ, Xu XN, Wang SY, Fu G, Zhang XL, Wang ZQ#, Brindley PJ, McManus DP, Xue CL, Feng Z, Chen Z, Han ZG. 2003. Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource. Nat Genet 35: 139-47
Wang Z*, Hong J*, Sun W, Xu G, Li N, Chen X, Liu A, Xu L, Sun B, Zhang JZ. 2006. Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs. J Clin Invest 116: 2434-41
Wang Z*, Qiu J*, Guo TB, Liu A, Wang Y, Li Y, Zhang JZ#. 2007. Anti-inflammatory properties and regulatory mechanism of a novel derivative of artemisinin in experimental autoimmune encephalomyelitis. J Immunol 179: 5958-65
Chen G*, Hao J, Xi Y, Wang W, Wang Z, Li N, Li W#. 2008. The therapeutic effect of vasoactive intestinal peptide on experimental arthritis is associated with CD4+CD25+ T regulatory cells. Scand J Immunol 68: 572-8
Wu CY*, Feng Y*, Qian GC, Wu JH, Luo J, Wang Y, Chen GJ, Guo XK#, Wang ZJ#. 2010. alpha-Galactosylceramide protects mice from lethal Coxsackievirus B3 infection and subsequent myocarditis. Clin Exp Immunol 162: 178-87
Sun H*, Zhuang G, Chai L, Wang Z, Johnson D, Ma Y, Chen YH#. 2012. TIPE2 controls innate immunity to RNA by targeting the phosphatidylinositol 3-kinase-Rac pathway. J Immunol 189: 2768-73
Wang Z*, Fayngerts S, Wang P, Sun H, Johnson DS, Ruan Q, Guo W, Chen YH#. 2012. TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection. Proc Natl Acad Sci U S A 109: 15413-8
Fayngerts SA*, Wu J, Oxley CL, Liu X, Vourekas A, Cathopoulis T, Wang Z, Cui J, Liu S, Sun H, Lemmon MA, Zhang L, Shi Y, Chen YH#. 2014. TIPE3 Is the Transfer Protein of Lipid Second Messengers that Promote Cancer. Cancer Cell 26: 465-78
Wu C*, Chen Q*, Fang Y, Wu J, Han Y, Wang Y, Yang Y, Chu M, Feng Y, Tan L, Guo X, Hu W, Wang Z#. 2014. Schistosoma japonicum egg specific protein SjE16.7 recruits neutrophils and induces inflammatory hepatic granuloma initiation. PLoS Negl Trop Dis 8: e2703
Cheng W*, Zhao Q*, Xi Y, Li C, Xu Y, Wang L, Niu X, Wang Z#, Chen G#. 2015. IFN-beta inhibits T cells accumulation in the central nervous system by reducing the expression and activity of chemokines in experimental autoimmune encephalomyelitis. Mol Immunol 64: 152-62
Fang Y*, Wu C, Chen Q, Wu J, Yang Y, Guo X, Chen G, Wang Z#. 2015. SjE16.7 activates macrophages and promotes Schistosoma japonicum egg-induced granuloma development. Acta Trop 149: 49-58
Porturas TP*, Sun H, Buchlis G, Lou Y, Liang X, Cathopoulis T, Fayngerts S, Johnson DS, Wang Z, Chen YH#. 2015. Crucial roles of TNFAIP8 protein in regulating apoptosis and Listeria infection. J Immunol 194: 5743-50
Zhang Z*, Liang X, Gao L, Ma H, Liu X, Pan Y, Yan W, Shan H, Wang Z, Chen YH#, Ma C#. 2015. TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells. Oncogene 34: 2566-74
Niu X*, Deng S*, Li S, Xi Y, Li C, Wang L, He D, Wang Z#, Chen G#. 2016. Therapeutic effect of ergotope peptides on CIA by down-regulation of inflammatory and Th1/Th17 responses and induction of regulatory T cells. Mol Med 22: 608-20
Fayngerts SA*, Wang Z*, Zamani A, Sun H, Boggs AE, Porturas TP, Xie W, Lin M, Cathopoulis T, Goldsmith JR, Vourekas A, Chen YH#. 2017. Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2. Nat Immunol 18: 1353-60 (co-first author)
Lao Y*, Yang K, Wang Z, Sun X, Zou Q, Yu X, Cheng J, Tong X, Yeh ETH, Yang J#, Yi J#. 2018. DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages. J Biol Chem 293: 3965-80
Yin C*, Wu C, Du X, Fang Y, Pu J, Wu J, Tang L, Zhao W, Weng Y, Guo X, Chen G#, Wang Z#. 2018. PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS. Front Immunol 9: 2609
Du XY*, Zhang Y*, Li X, Li Q, Wu CY, Chen GJ, Guo XK, Weng YQ#, Wang ZJ#. 2019. PRL2 serves as a negative regulator in cell adaptation to oxidative stress. Cell and Bioscience 9
Wu C*, Du X*, Tang L, Wu J, Zhao W, Guo X, Liu D, Hu W, Helmby H, Chen G#, Wang Z#. 2020. Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE). Front Immunol 11: 1767
Cai F*, Liu S*, Lei Y, Jin S, Guo Z, Zhu D, Guo X, Zhao H, Niu X, Xi Y, Wang Z#, Chen G#. 2021. Epigallocatechin-3 gallate regulates macrophage subtypes and immunometabolism to ameliorate experimental autoimmune encephalomyelitis. Cellular Immunology 368