Research Field: Immune Cell Signaling and Metabolism
Dr. Feng Wang is a Professor and Principal Investigator at Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine. Dr. Wang obtained his BS from Beijing Normal University, PhD from National Institute of Biological Sciences, Beijing (NIBS), and received postdoc trainings at Stanford University with Prof. Mark M Davis. His recent publications including Nature Immunology (2016), PNAS (2018, 2020), Journal of Neuroinflammation (2019), BMC Biology (2020), Clinical & Translational Immunology (2020), Frontiers in Cell and Developmental Biology (2021), Cell Death & Disease (2021), Cell & Bioscience (2022), EMBO Journal (2022). Dr. Feng Wang was awarded with the National High Level Talents Special Support Plan, the Program for Professor of Special Appointment (Eastern Scholar), Shanghai Pujiang Program and the Top Young Talent Program of Shanghai.
Scientific Research Projects
The long-term goal of Dr. Wang’s laboratory is to harness the immune system to fight cancer and infectious diseases. The rationale for this proposed goal is that, once it is known how T cell recognition/signaling is determined and regulated, these processes can likely be manipulated pharmacologically or genetically, leading to innovative approaches to optimize the immune response for preventing and treating various human diseases.
The research in Dr. Wang’s laboratory focuses on the mechanism of antigen recognition, signaling transduction and metabolic regulation of T lymphocytes. Three research directions include: (1) Regulation of T cell signaling by naturally occurring metabolites; (2) The role of antigen-specific T cell in anti-tumor and anti-viral immune response; (3) The mechanism of anti-tumor immunity and autoimmunity induced by immune checkpoint blockade.
Wang Q, Zhu T, Miao N, Qu Y, Wang Z, Chao Y, Wang J, Wu W, Xu X, Xu C, Xia L, Wang F#. Disulfiram bolsters T cell anti-tumor immunity through direct activation of LCK-mediated TCR signaling. EMBO Journal, 2022, doi: 10.15252/embj.2022110636.
Zhao X, Liang W, Wang Y, Yi R, Luo L, Wang W, Sun N, Yu M, Xu W, Sheng Q, Lu L, Pang J, Lv Z#, Wang F#. Ontogeny of RORγt+ cells in the intestine of newborns and its role in the development of experimental necrotizing enterocolitis. Cell & Bioscience, 2022, doi.org/10.1186/s13578-021-00739-6.
Wang Y, Jin H, Wang Y, Yao Y, Yang C, Meng J, Tan X, Nie Y, Xue L, Xu B, Zhao H, Wang F#. Sult2b1 deficiency exacerbates ischemic stroke by promoting pro-inflammatory macrophage polarization in mice. Theranostics, 2021; 11(20):10074-10090. doi:10.7150/thno.61646.
Luo L, Liang W, Pang J, Xu G, Chen Y, Guo X, Wang X, Zhao Y, Lai Y, Liu Y, Li B, Su B, Zhang S, Baniyash M, Shen L, Chen L, Ling Y, Wang Y, Liang Q, Lu H, Zhang Z, Wang F#. Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals. Cell Discovery, 2021, 7(1):89. doi: 10.1038/s41421-021-00321-x.
Qian Y, Yu W, Grzeskowiak C, Li J, Huang H, Guo J, Chen L, Wang F, Zhao F, Boehmer L, Metzner T, Leppert J, Chien Y, Kuo C, Davis MM. Nanoparticle-enabled innate immune stimulation activates endogenous tumor infiltrating T cells with broad antigen specificities. PNAS, 2021, doi.org/10.1073/pnas.2016168118.
Zhao X, Luo X, Sun R, Wang F#, and Sun X#. The interaction between microglia and macroglia in glaucoma, Frontiers in Neuroscience, 2021, doi: 10.3389/fnins.2021.610788.
Wang Y, Zhao X, Gao M, Wan X, Guo Y, Qu Y, Chen Y, Li T, Liu H, Jiang M, Wang F#, and Sun X#. Myosin 1f-mediated Activation of Microglia Contributes to the Photoreceptor Degeneration in a Mouse Model of Retinal Detachment. Cell Death & Disease, 2021, DOI:10.21203/rs.3.rs-80015/v1.
Zhao X, Gao M, Liang J, Chen Y, Wang Y, Wang Y, Xiao Y, Zhao Z, Wan X, Jiang M, Luo X, Wang F#, and Sun X#. SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production. Frontiers in Cell and Developmental Biology, 2021, Doi: 10.3389/fcell.2021.639851.
Ren X, Wen W, Fan X, Hou W, Su B, Cai P, Li J, Liu Y, Tang F, Zhang F, Yang Y, He J, Ma W, He J, Wang P, Cao Q, Chen F, Chen Y, Cheng X, Deng G, Deng X, Ding W, Feng Y, Gan R, Guo C, Guo W, He S, Chen J, Liang J, Li Y, Lin J, Ling Y, Liu H, Liu J, Liu N, Liu S, Luo M, Ma Q, Song Q, Sun W, Wang G, Wang F, Wang Y, Wen X, Wu Q, Xu G, Xie X, Xiong X, Xing X, Xu H, Yin C, Yu D, Yu K, Yuan J, Zhang B, Zhang P, Zhang T, Zhao J, Zhao P, Zhou J, Zhou W, Zhong S, Zhong X, Zhang S, Zhu L, Zhu P, Zou B, Zou J, Zou Z, Bai F, Huang X, Zhou P#, Jiang Q#, Huang Z#, Bei J#, Wei L#, Bian X#, Liu X#, Cheng T#, Li X#, Zhao P#, Wang F#, Wang H#, Su B#, Zhang Z#, Qu K#, Wang X#, Chen J#, Jin R#, Zhang Z#. COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas. Cell, 2021, DOI: 10.1016/j.cell.2021.01.053.
Sun S, Luo L, Liang W, Yin Q, Guo J, Rush MA, Lv Z, Liang Q, Fischbach AM, Sonnenburg LJ, Dodd D, Davis MM#, Wang F#. Bifidobacterium alters the gut microbiota and modulates the functional metabolism of Treg cells in the context of CTLA-4 blockade. PNAS, 2020, 117(44): 27509-27515.
Li Y, Wang Y, Yao Y, Griffiths BB, Feng L, Tao T, Wang F, Xu B, Stary CM, Zhao H. Systematic Study of the Immune Components after Ischemic Stroke Using CyTOF Techniques, Journal of Immunology Research, 2020, DOI:https://doi.org/10.1155/2020/9132410.
Zeng J, Dong S, Luo Z, Xie X, Fu B, Li P, Liu C, Yang X, Chen Y, Wang X, Liu Z, Wu J, Yan Y, Wang F, Chen J, Zhang J, Long G, Goldman SA, Li S, Zhao Z, Liang Q. The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis. Cell Stem Cell, 2020, DOI:https://doi.org/10.1016/j.stem.2020.07.012.
Zhang S, Liang W, Luo L, Sun S, Wang F#. The role of T cell trafficking in CTLA-4-blockade induced gut immunopathology. BMC Biology, 2020, 18(1):29. doi.org/10.1186/s12915-020-00765-9.
Leng Q#, Tarbe M, Long Q, Wang F#. Preexisting heterologous T cell immunity and neoantigen immunogenicity. Clinical & Translational Immunology, 2020, 9:3. doi: 10.1002/cti2.1111.
Hu Z, Qu G, Yu X, Jiang H, Teng XL, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li HB, Chen L, Jiang J, Su B#, Liu J#, Zou Q#. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metabolism, 2019, 30(2):290-302.
Wang Y, Jin H, Wang W, Wang F#, Zhao H#. Myosin1f-mediated neutrophil migration contributes to acute neuroinflammation and brain injury after stroke in mice. Journal of Neuroinflammation, 2019, 16(1):77. doi: 10.1186/s12974-019-1465-9.
Wang F#, Yin Q, Chen L, and Davis MM#. Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade. PNAS, 2018, 115(1): 157-161.
Wang F, Beck-García K, Zorzin C, Schamel WW, and Davis MM. Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol. Nature Immunology, 2016, 17(7): 844-850.
Zhu P, Wang Y, Oin N, Wang F, Wang J, Deng XW, Zhu D. An Arabidopsis small nucleolar RNA monitors the efficient pre-rRNA processing during ribosome biogenesis. PNAS, 2016, 113(42): 11967-11972.
Roh KH, Lillemeier BF, Wang F, and Davis MM. The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck. PNAS, 2015, 112(13): 1604-1613.
201910119143.7, Inventor: Wang F
201910533938.2 (PCT/CN2020/096054), Inventor: Wang F
201911164594.9, Inventor: Wang F
201911165137.1, Inventor: Wang F
202010933076.5, Inventors: Wang F, Wang Q
202110421940.8, Inventors: Wang F, Yang C
202111091720.X, Inventors: Wang F, Luo L