Room 902, No.5 Bldg., West Campus, 280 South Chongqing Rd., Shanghai, China, 200025
B.S., Jilin University, Changchun, Jilin, China 2007
Ph.D., Florida State University, Tallahassee, FL, USA (Mentor: Fanxiu Zhu) 2011
2012-2016 Postdoctoral Fellow, University of Southern California, USA (Mentor: Dr. Jae U Jung)
2016-present Principal Investigator, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
HONORS AND RECOGNITION
2015 Special Fellow Award, Leukemia & Lymphoma Society, USA
2016 The Program for Professor of Special Appointment (Eastern Scholar)
2017 The Recruitment Program of Global Experts of China
2017 Shanghai Rising-Star Program
2014-present American Society for Microbiology, USA
2017-present Shanghai Society for Microbiology, China
2017-2019 Member of the Microbiome Committee of Shanghai Society for Microbiology
AD HOC REVIEWER
2013-present Applied Microbiology and Biotechnology
2014-present Antioxidants and Redox Signaling, Frontiers in Cellular and Infection Microbiology, Journal of Virological Methods
2016-present PLoS Pathogens, Journal of Virology, Journal of Molecular Cell Biology
2020-present Nature Communications
GRANT REVIEW/SERVICE ON MOST/NSFC/STCSM/NIH/OTHER STUDY SECTIONS
2017-present Invited Reviewer for Chinese NSFC General and Youth Program
2020-present Invited Reviewer for Changjiang Scholar (Youth)
2021-present Invited Reviewer for Research Grants Council of Hong Kong
2020-present Director of BSL-2 lab at SJTU-SM
2020-present Member of Post-doctor Committee for SII
2021-present Member of PI Search Committee for SII
PAST GRANT SUPPORT
The role of vBcl2 in Kaposi’s Sarcoma-associated Herpesvirus persistent infection. Funding Source: Leukemia & Lymphoma Society, USA, Grant Number: 3357-16, 2015/07-2018/06.
The interaction between virus and host. Funding Source: Shanghai Institutions of Higher learning, Grant Number: 2016, 2016/04-2018/12.
The molecular mechanism for Zika virus immune evasion. Funding Source: Shanghai Science and Technology Committee. Grant Number: 2017QA1403200, 2017/03-2020/02.
The molecular mechanism for Zika virus NS4A and NS4B induced autophagy, Funding Source: National Natural Science Foundation of China, Grant Number: 31770176, 2017/01-2021/12.
The mechanism by which vBcl2 affects KSHV pathogenesis, Funding Source: Shanghai Municipal Health Commission, Grant Number: 2018YQ40, 2018/07-2021/06.
Identification of host targets for SARS-CoV-2. Funding Source: Shanghai Jiao Tong University, Grant Number: YG2020YQ14, 2020/04-2021/06.
CURRENT GRANT SUPPORT
Attenuated vaccine design and synthesis based on immune evasion mechanism. Funding Source: The Ministry of Science and Technology of China, Grant Number: 2018YFA0900802, 2019/07-2024/06.
The role of RSK1 SUMOylation in KSHV lytic replication. Funding Source: Shanghai Science and Technology Committee, Grant Number: 22ZR1454500, 2022/03-2025/03.
INVITED SPEAKERS AT CONFERENCE
"Virion-associated Bcl2 homolog is essential for KSHV assembly." 4th Chinese Herpesvirus conference, Wuhan, Hubei Province, China. 2016.
"The molecular mechanism by which Zika virus inhibits the proliferation and differentiation of neural stem cells." 1st International Symposium on Frontiers of Life Science, Changchun, Jilin Province, China. 2017.
"vBcl2 is required for multiple aspects of KSHV lytic replication." 5th Chinese Herpesvirus conference, Shenyang, Liaoning Province, China. 2017.
"Virus-host interactome reveals the unique blockage of host RNAi machinery by Zika virus." International Forum on Immunity (SII-CML Immunology symposium), Shanghai, China. 2018.
"Virus-host interactome reveals the unique blockage of host RNAi machinery by Zika virus." CBIS Annual Meeting, Shenzhen, Guangdong Province, China. 2018.
"Virus-host interactome reveals the unique blockage of host RNAi machinery by Zika virus." CBIS Annual Meeting, Wuhan, Hubei Province, China. 2019.
INVITED SEMINARS FROM OTHER UNIVERSITIES AND INSTITUTIONS
“Battles between virus and host innate immunity”, Wuhan University, Wuhan, China. 2017
“Identification of an anti-KSHV peptide”, Northeast Forestry University, Harbin, China. 2017
“Identification of an anti-KSHV peptide”, Ruijin Hospital, Shanghai, China. 2017
"Virus-host interactome reveals the unique blockage of host RNAi machinery by Zika virus”. USC Ostrow School of Dentistry, Los Angeles, CA, USA. 2019
"Virus-host interactome reveals the unique blockage of host RNAi machinery by Zika virus”. USC Keck School of Medicine, Los Angeles, CA, USA. 2019
"Virus-host interactome reveals the unique blockage of host RNAi machinery by Zika virus." Wuhan Institute of Virology, Wuhan, Hubei Province, China. 2019.
Yang X#, Zhou J#, Liu C#, Qu Y, Wang W, Xiao MZX, Zhu F, Liu Z, and Liang Q*. (2022) KSHV-encoded ORF45 activates human NLRP1 inflammasome. Nature Immunology. Online ahead of print.
Liu Z#, Wang X#, Liu C#, Deng H#, Li W#, Wang X, Xu X, Xiao MZX, Wang C, Zhang Y, Fu J, Zhu F*, and Liang Q*. (2022) The SUMO E3 ligase activity of ORF45 determines KSHV lytic replication. PLoS Pathogens. 18(4): e1010504.
Dong S#, Xie X#, Chen Y, Long G, Liang Q*, Zhao Z*, and Zeng J*. (2022) Protocol for in utero injection to investigate Zika virus related fetal microcephaly. STAR Protocols. 3(1): 101057.
Liu Z#, Liu C#, Wang X#, Li W#, Zhou J, Dong P, Xiao MZX, Zhu F*, and Liang Q*. (2021) RSK1 SUMOylation is required for KSHV lytic replication. PLoS Pathogens. 17(12): e1010123.
Luo L#, Liang W#, Pang J#, Xu G#, Chen Y#, Guo X, Wang X, Zhao Y, Lai Y, Liu Y, Li B, Su B, Zhang S, Baniyash M, Shen L, Chen L, Ling Y, Wang Y, Liang Q, Lu H*, Zhang Z*, and Wang F*. (2021) Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals. Cell Discovery. 7(1):89.
Qu Y#, Wang X#, Zhu Y#, Wang W#, Wang Y, Hu G, Liu C, Li J, Ren S, Xiao MZX, Liu Z, Wang C, Fu J, Zhang Y*, Li P*, Zhang R*, and Liang Q*. (2021) ORF3a-mediated incomplete autophagy facilitates Severe Acute Respiratory Syndrome Coronavirus-2 replication. Front Cell Dev Biol. 9:716208. Doi: 10.3389/fcell.2021.716208.
Zhang Y, Chen M, Liu C, Chen J, Luo X, Xue Y, Liang Q, Zhou L, Tao Y, Li M, Wang D*, Zhou J, Wang J*. (2021) Sensitive and rapid on-site detection of SARS-CoV-2 using a gold nanoparticle-based high-throughput platform coupled with CRISPR/Cas12-assisted RT-LAMP. Sens Actuators B Chem. 345: 130411.
Zeng J#, Luo Z#, Dong S, Xie X, Liang X, Yan Y, Liang Q, and Zhao Z*. (2021) Functional mapping of AGO-associated Zika virus-derived small interfering RNAs in neural stem cells. Front Cell Infect Microbiol. 11:628887. doi: 10.3389/fcimb.2021.628887.
Li J#, Guo M#, Tian X#, Wang X#, Yang X#, Wu P#, Liu C#, Xiao Z, Qu Y, Yin Y, Wang C, Zhang Y, Zhu Z, Liu Z*, Peng C*, Zhu T*, and Liang Q*. (2021) Virus-host interactome and proteomic survey reveal potential virulence factors influencing SARS-CoV-2 pathogenesis. Med (NY). 2(1): 99-112.
Sun S#, Luo L#, Liang W#, Yin Q, Guo J, Rush AM, Lv Z, Liang Q, Fischbach MA, Sonnenburg JL, Dodd D, Davis MM*, and Wang F*. (2020) Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockage. PNAS. 117(44): 27509-27515.
Zeng J#, Dong S#, Luo Z#, Xie X#, Fu B#, Li P#, Liu C#, Yang X, Chen Y, Wang X, Liu Z, Wu J, Yan Y, Wang F, Chen JF, Zhang J, Long G, Goldman SA, Li S*, Zhao Z*, and Liang Q*. (2020) The Zika virus capsid disrupts corticogenesis by suppressing Dicer activity and miRNA biogenesis. Cell Stem Cell. 27(4): 618-632.
Dong S, Liang Q*. (2018) Recent advances of animal models for Zika virus. Virologica Sinica. 33(2): 125-130.
Liang Q*#, Wei D#, Chang B, Brulois KF, Guo C, Dong S, Feng P, Gao SJ, Liang C, and Jung JU*. (2018) A novel role of vBcl2 in the virion assembly of Kaposi’s sarcoma-associated herpesvirus. Journal of Virology. 92(4): 5308-17.
Gao H#, Song Y#, Liu C, Liang Q*. (2016) KSHV strategies for host dsDNA sensing machinery. Virologica Sinica. 31(6):466-471.
Liang Q*, Luo Z, Zeng J, Chen W, Foo SS, Lee SA, Ge J, Wang S, Goldman SA, Zlokovic BV, Zhao Z*, and Jung JU*. (2016) Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy. Cell Stem Cell. 19(6): 663-671.
COURSES TAUGHT AND ROLES，AND LECTURES TAUGHT
Shanghai Jiao Tong University School of Medicine: “Basic Disease 1”.
Shanghai Jiao Tong University School of Medicine: “Advanced Immunology and Technology”.
Shanghai Jiao Tong University School of Medicine: “Introduction of Research”.
DIRECT SUPERVISION FOR POSTDOCTORS AND GRADUATE STUDENTS
2016-2019 Changrun Guo, Ph.D. (Jilin University)
2017-2019 Xin Wang, Ph.D. (Nanjing Agricultural University)
2020-2022 Jingjiao Li, Ph.D. (Shanghai Jiao Tong University)
2021-present Shupeng Dong, Ph.D. (Shanghai Jiao Tong University)
2016-2021 Shupeng Dong, Ph.D.
2017-2021 Xing Yang, Ph.D.
2018-present Yafei Qu, Ph.D. candidate
2019-present Weili Wang, Ph.D. candidate
2020-present Jingfan Zhou, Ph.D. candidate
2020-present Biyao Chen, Ph.D. candidate
2020-present Peixian Dong, Master candidate
2021-present Xiaoqian Wang, Ph.D. candidate
2021-present Qingyu Guo, Ph.D. candidate
2021-present Xue Xu, Master candidate