College of Basic Medical Sciences

LIANG Qiming


Room 902, No.5 Bldg., West Campus, 280 South Chongqing Rd., Shanghai, China, 200025

Phone: 86-021-54270236



  • B.S., Jilin University, Changchun, Jilin, China                     2007

  • Ph.D., Florida State University, Tallahassee, FL, USA (Mentor: Fanxiu Zhu) 2011


  • 2012-2016   Postdoctoral Fellow, University of Southern California, USA (Mentor: Dr. Jae U Jung)

  • 2016-present Principal Investigator, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China


  • 2015 Special Fellow Award, Leukemia & Lymphoma Society, USA

  • 2016 The Program for Professor of Special Appointment (Eastern Scholar)

  • 2017 The Recruitment Program of Global Experts of China

  • 2017 Shanghai Rising-Star Program


  • 2014-present American Society for Microbiology, USA

  • 2017-present Shanghai Society for Microbiology, China

  • 2017-2019 Member of the Microbiome Committee of Shanghai Society for Microbiology



  • 2013-present    Applied Microbiology and Biotechnology

  • 2014-present    Antioxidants and Redox Signaling, Frontiers in Cellular and Infection Microbiology, Journal of Virological Methods

  • 2016-present    PLoS Pathogens, Journal of Virology, Journal of Molecular Cell Biology

  • 2020-present    Nature Communications


  • 2017-present    Invited Reviewer for Chinese NSFC General and Youth Program

  • 2020-present    Invited Reviewer for Changjiang Scholar (Youth)

  • 2021-present    Invited Reviewer for Research Grants Council of Hong Kong


  • 2020-present     Director of BSL-2 lab at SJTU-SM

  • 2020-present     Member of Post-doctor Committee for SII

  • 2021-present     Member of PI Search Committee for SII



  • The role of vBcl2 in Kaposi’s Sarcoma-associated Herpesvirus persistent infection. Funding Source: Leukemia & Lymphoma Society, USA, Grant Number: 3357-16, 2015/07-2018/06.

  • The interaction between virus and host. Funding Source: Shanghai Institutions of Higher learning, Grant Number: 2016, 2016/04-2018/12.

  • The molecular mechanism for Zika virus immune evasion. Funding Source: Shanghai Science and Technology Committee. Grant Number: 2017QA1403200, 2017/03-2020/02.

  • The molecular mechanism for Zika virus NS4A and NS4B induced autophagy, Funding Source: National Natural Science Foundation of China, Grant Number: 31770176, 2017/01-2021/12.

  • The mechanism by which vBcl2 affects KSHV pathogenesis, Funding Source: Shanghai Municipal Health Commission, Grant Number: 2018YQ40, 2018/07-2021/06.

  • Identification of host targets for SARS-CoV-2. Funding Source: Shanghai Jiao Tong University, Grant Number: YG2020YQ14, 2020/04-2021/06.


  • Attenuated vaccine design and synthesis based on immune evasion mechanism. Funding Source: The Ministry of Science and Technology of China, Grant Number: 2018YFA0900802, 2019/07-2024/06.

  • The role of RSK1 SUMOylation in KSHV lytic replication. Funding Source: Shanghai Science and Technology Committee, Grant Number: 22ZR1454500, 2022/03-2025/03.



  • "Virion-associated Bcl2 homolog is essential for KSHV assembly." 4th Chinese Herpesvirus conference, Wuhan, Hubei Province, China. 2016.

  • "The molecular mechanism by which Zika virus inhibits the proliferation and differentiation of neural stem cells." 1st International Symposium on Frontiers of Life Science, Changchun, Jilin Province, China. 2017.

  • "vBcl2 is required for multiple aspects of KSHV lytic replication." 5th Chinese Herpesvirus conference, Shenyang, Liaoning Province, China. 2017.

  • "Virus-host interactome reveals the unique blockage of host RNAi machinery by Zika virus." International Forum on Immunity (SII-CML Immunology symposium), Shanghai, China. 2018.

  • "Virus-host interactome reveals the unique blockage of host RNAi machinery by Zika virus." CBIS Annual Meeting, Shenzhen, Guangdong Province, China. 2018.

  • "Virus-host interactome reveals the unique blockage of host RNAi machinery by Zika virus." CBIS Annual Meeting, Wuhan, Hubei Province, China. 2019.


  • “Battles between virus and host innate immunity”, Wuhan University, Wuhan, China. 2017

  • “Identification of an anti-KSHV peptide”, Northeast Forestry University, Harbin, China. 2017

  • “Identification of an anti-KSHV peptide”, Ruijin Hospital, Shanghai, China. 2017

  • "Virus-host interactome reveals the unique blockage of host RNAi machinery by Zika virus”. USC Ostrow School of Dentistry, Los Angeles, CA, USA. 2019

  • "Virus-host interactome reveals the unique blockage of host RNAi machinery by Zika virus”. USC Keck School of Medicine, Los Angeles, CA, USA. 2019

  • "Virus-host interactome reveals the unique blockage of host RNAi machinery by Zika virus." Wuhan Institute of Virology, Wuhan, Hubei Province, China. 2019.


  • Yang X#, Zhou J#, Liu C#, Qu Y, Wang W, Xiao MZX, Zhu F, Liu Z, and Liang Q*. (2022) KSHV-encoded ORF45 activates human NLRP1 inflammasome. Nature Immunology. Online ahead of print.

  • Liu Z#, Wang X#, Liu C#, Deng H#, Li W#, Wang X, Xu X, Xiao MZX, Wang C, Zhang Y, Fu J, Zhu F*, and Liang Q*. (2022) The SUMO E3 ligase activity of ORF45 determines KSHV lytic replication. PLoS Pathogens. 18(4): e1010504.

  • Dong S#, Xie X#, Chen Y, Long G, Liang Q*, Zhao Z*, and Zeng J*. (2022) Protocol for in utero injection to investigate Zika virus related fetal microcephaly. STAR Protocols. 3(1): 101057.

  • Liu Z#, Liu C#, Wang X#, Li W#, Zhou J, Dong P, Xiao MZX, Zhu F*, and Liang Q*. (2021) RSK1 SUMOylation is required for KSHV lytic replication. PLoS Pathogens. 17(12): e1010123.

  • Luo L#, Liang W#, Pang J#, Xu G#, Chen Y#, Guo X, Wang X, Zhao Y, Lai Y, Liu Y, Li B, Su B, Zhang S, Baniyash M, Shen L, Chen L, Ling Y, Wang Y, Liang Q, Lu H*, Zhang Z*, and Wang F*. (2021) Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals. Cell Discovery. 7(1):89.

  • Qu Y#, Wang X#, Zhu Y#, Wang W#, Wang Y, Hu G, Liu C, Li J, Ren S, Xiao MZX, Liu Z, Wang C, Fu J, Zhang Y*, Li P*, Zhang R*, and Liang Q*. (2021) ORF3a-mediated incomplete autophagy facilitates Severe Acute Respiratory Syndrome Coronavirus-2 replication. Front Cell Dev Biol. 9:716208. Doi: 10.3389/fcell.2021.716208.

  • Zhang Y, Chen M, Liu C, Chen J, Luo X, Xue Y, Liang Q, Zhou L, Tao Y, Li M, Wang D*, Zhou J, Wang J*. (2021) Sensitive and rapid on-site detection of SARS-CoV-2 using a gold nanoparticle-based high-throughput platform coupled with CRISPR/Cas12-assisted RT-LAMP. Sens Actuators B Chem. 345: 130411.

  • Zeng J#, Luo Z#, Dong S, Xie X, Liang X, Yan Y, Liang Q, and Zhao Z*. (2021) Functional mapping of AGO-associated Zika virus-derived small interfering RNAs in neural stem cells. Front Cell Infect Microbiol. 11:628887. doi: 10.3389/fcimb.2021.628887.

  • Li J#, Guo M#, Tian X#, Wang X#, Yang X#, Wu P#, Liu C#, Xiao Z, Qu Y, Yin Y, Wang C, Zhang Y, Zhu Z, Liu Z*, Peng C*, Zhu T*, and Liang Q*. (2021) Virus-host interactome and proteomic survey reveal potential virulence factors influencing SARS-CoV-2 pathogenesis. Med (NY). 2(1): 99-112.

  • Sun S#, Luo L#, Liang W#, Yin Q, Guo J, Rush AM, Lv Z, Liang Q, Fischbach MA, Sonnenburg JL, Dodd D, Davis MM*, and Wang F*. (2020) Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockage. PNAS. 117(44): 27509-27515.

  • Zeng J#, Dong S#, Luo Z#, Xie X#, Fu B#, Li P#, Liu C#, Yang X, Chen Y, Wang X, Liu Z, Wu J, Yan Y, Wang F, Chen JF, Zhang J, Long G, Goldman SA, Li S*, Zhao Z*, and Liang Q*. (2020) The Zika virus capsid disrupts corticogenesis by suppressing Dicer activity and miRNA biogenesis. Cell Stem Cell. 27(4): 618-632.

  • Dong S, Liang Q*. (2018) Recent advances of animal models for Zika virus. Virologica Sinica. 33(2): 125-130.

  • Liang Q*#, Wei D#, Chang B, Brulois KF, Guo C, Dong S, Feng P, Gao SJ, Liang C, and Jung JU*. (2018) A novel role of vBcl2 in the virion assembly of Kaposi’s sarcoma-associated herpesvirus. Journal of Virology. 92(4): 5308-17.

  • Gao H#, Song Y#, Liu C, Liang Q*. (2016) KSHV strategies for host dsDNA sensing machinery. Virologica Sinica. 31(6):466-471.

  • Liang Q*, Luo Z, Zeng J, Chen W, Foo SS, Lee SA, Ge J, Wang S, Goldman SA, Zlokovic BV, Zhao Z*, and Jung JU*. (2016) Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy. Cell Stem Cell. 19(6): 663-671.




  • Shanghai Jiao Tong University School of Medicine: “Basic Disease 1”.


  • Shanghai Jiao Tong University School of Medicine: “Advanced Immunology and Technology”.


  • Shanghai Jiao Tong University School of Medicine: “Introduction of Research”.



  • 2016-2019     Changrun Guo, Ph.D. (Jilin University)

  • 2017-2019     Xin Wang, Ph.D. (Nanjing Agricultural University)

  • 2020-2022     Jingjiao Li, Ph.D. (Shanghai Jiao Tong University)

  • 2021-present   Shupeng Dong, Ph.D. (Shanghai Jiao Tong University)


  • 2016-2021     Shupeng Dong, Ph.D.

  • 2017-2021     Xing Yang, Ph.D.

  • 2018-present   Yafei Qu, Ph.D. candidate

  • 2019-present   Weili Wang, Ph.D. candidate

  • 2020-present   Jingfan Zhou, Ph.D. candidate

  • 2020-present   Biyao Chen, Ph.D. candidate

  • 2020-present   Peixian Dong, Master candidate

  • 2021-present   Xiaoqian Wang, Ph.D. candidate

  • 2021-present   Qingyu Guo, Ph.D. candidate

  • 2021-present   Xue Xu, Master candidate