College of Basic Medical Sciences




Tel: 63846590-776986

Personal Introduction

  • Dr. Ju Huang received her B.S. degree from Fudan University, School of Medicine in 2006 and her Ph.D. degree from Institute of Neuroscience, Chinese Academy of Sciences in 2011. From 2011 to 2016, she got her postdoc training at Harvard Medical School and then Washington University in St. Louis in the USA. In 2016, Dr. Huang joined Shanghai Jiao Tong University, School of Medicine as the principal investigator and the head of the Laboratory of Innate Behavior and Emotion Regulation.

Research Interest

  • Our lab has long been committed to the research of neural-circuit-level and molecular-level mechanisms of innate behavior and emotion regulation, with a series of research achievements in the functional roles of disease-related proteins, epigenetic regulation, and neural circuitry in feeding regulation, thermoregulation, and repetitive behaviors. Our current research work focus on the relationship between innate behaviors and emotion regulation, especially the mechanism mediating the impact of repetitive behaviors on post-stress anxiety-regulation, and the intervention of repetitive behaviors that are associated with neuropsychiatric disorders. We aim to provide a new perspective and insight for our understanding of the neurobiological mechanisms in innate behavior and emotion regulation.

Scientific Research Projects

  • The program supported by the Ministry of Science and Technology of the People's Republic of China (2021ZD0202800/01).

  • The programs supported by the Natural Science Foundation of China (32070957 and 81771215).

  • The program supported by the Science and Technology Commission of Shanghai Municipality (18JC1420302).

  • The program for Professor of Special Appointment (Eastern Scholar for J.H.) at Shanghai Institutions for Higher Learning (1710000221).

  • The Shanghai Pujiang Program (17PJ1405300).


  • Di Chen; Yi-Yu Sun; Lai-Yang Zhou; Shuo Yang; Fei-Yang Hong; Xian-Dong Liu; Zhao-Liang Sun; Ju Huang*; Dong-Fu Feng*. Maf1 regulates axonal regeneration of retinal ganglion cells after injury. Experimental Neurology, 2022, 348: 113948

  • Shuo Yang; Yu Lin Tan; Xiaohua Wu; Jingjie Wang; Jingjing Sun; Anqi Liu; Linhua Gan; Bo Shen; Xiaocui Zhang; Yu Fu; Ju Huang*. An mPOA-ARC AgRP pathway modulates cold-evoked eating behavior. Cell Reports, 2021, 36(6): 109502

  • Yuntao Lu; Bing Liu; Junjie Ma; Shuo Yang; Ju Huang*. Disruption of Circadian transcriptome in lung by acute sleep deprivation. Frontiers in Genetics, 2021, 12: 664334

  • Linhua Gan; Jingjing Sun; Shuo Yang; Xiaocui Zhang; Wu Chen; Yiyu Sun; Xiaohua Wu; Cheng Cheng; Jing Yuan; Anan Li; Mark A. Corbett; Mathew P. Dixon; Tim Thomas; Anne K. Voss; Jozef Ge´cz; Guang-Zhong Wang; Azad Bonni; Qian Li; Ju Huang*. Chromatin-binding protein PHF6 regulates activity-dependent transcriptional networks to promote hunger response. Cell Reports, 2020, 30: 3717-3728

  • Sarah Xinwei Luo#; Ju Huang#; Qin Li#; Hasan Mohammad; Chun-Yao Lee; Kumar Krishna; Alison Maun-Yeng Kok; Yu Lin Tan; Joy Yi Lim; Hongyu Li; Ling Yun Yeow; Jingjing Sun; Miao He; Joanes Grandjean; Sreedharan Sajikumar; Weiping Han; Yu Fu*. Regulation of feeding by somatostatin neurons in the tuberal nucleus. Science, 2018, 361: 76-81

  • Pamela Valnegri; Ju Huang; Tomoko Yamada; Yue Yang; Luis A. Mejia; Ha Y. Cho; Anna Oldenborg; Azad Bonni. RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain. Nature Communications, 2017, 8: 1271

  • Ju Huang and Azad Bonni. A decade of the anaphase-promoting complex in the Nervous System. Genes & Development, 2016, 30(6): 622-638

  • Ju Huang; Yoshiho Ikeuchi; Marcos Malumbres; Azad Bonni; A Cdh1-APC/FMRP ubiquitin signaling link drives mGluR-dependent synaptic plasticity in the mammalian brain. Neuron, 2015, 68(3):726-739

  • Chi Zhang; Luis A. Mejia; Ju Huang; Pamela Valnegri; Eric J. Bennett; Julius Anckar; Arezu Jahani-Asl; Gilbert Gallardo; Yoshiho Ikeuchi; Tomoko Yamada; Michael Rudnicki; J. Wade Harper; Azad Bonni. The X-linked mental retardation protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain. Neuron, 2013, 78(6): 986-993

  • Tomoko Yamada; Yue Yang; Ju Huang; Giovanni Coppola; Daniel H Geschwind; Azad Bonni. Sumoylated MEF2A coordinately eliminates orphan presynaptic sites and promotes maturation of presynaptic boutons. Journal of Neuroscience, 2013, 33(11): 4726-4740

  • Ju Huang; Wei Zhang; Wenhui Qiao; Aiqun Hu; Zuoren Wang. Functional Connectivity and Selective Odor Responses of Excitatory Local Interneurons in Drosophila Antennal Lobe. Neuron, 2010,67: 1021-1033