Research Field: Structural mechanisms of cardiovascular diseases and cancer immunotherapy
Dr.Zhou obtained his Ph D degrees from Nanjing University in 1997, and then worked in the Department of Hematology of Cambridge University till 2012. He became BHF lecturer in 2006 and led a research group independently. He joined Shanghai Jiao tong University School of medicine as a professor of structural biology in 2012. His research has been focused on the structural mechanisms of many proteins associated with cardiovascular diseases and cancer immunotherapy through biochemical techniques and biophysical methods such as X-ray crystallography and Cryo-Electron microscopy. Over the years, his group has illustrated how protein conformational changes are associated with the onset of various diseases and provided new insights for further clinical treatment. The research group has published more than 40 research papers including Nature (2010,2019), Blood (2009,2012,2022), Science Advance (2020) etc.
*Zeng J, Shu Z, Liang Q, Zhang J, Wu W, *Wang X, *Zhou A. Structural basis of von Willebrand factor multimerization and tubular storage. Blood. 2022 Jun 2;139(22):3314-3324.
Shu Z, *Zeng J, Xia L, *Cai H, *Zhou A. Structural mechanism of VWF D'D3 dimer formation. Cell Discov. 2022 Feb15;8(1):14. doi:10.1038/s41421-022-00378-2.
Gao H, Cai H, Liu J, Wang X, Zheng P, Devenport M, Xu T, *Dou F, *Liu Y, *Zhou A. Structure of CTLA-4 complexed with a pH-sensitive cancer immunotherapeutic antibody. Cell Discov. 2020 Nov 3;6(1):79.
Zhang S，Heyes DJ，Feng L, Sun W, Johannissen LO, Liu H, Levy CW, Li X, Yang J, Yu X, Lin M, Hardman SJO, Hoeven R, Sakuma M, Hay S, Leys D, Rao Z, *Zhou A, *Cheng Q and *Scrutton NS. Structural basis for light-driven enzyme catalysis in chlorophyll biosynthesis. Nature, 2019 574, 722–725.
Zhang F, Wei H, Wang X, Bai Y, Wang P, Wu J, Jiang X, Wang Y, Cai H, *Xu T, *Zhou A. Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade. Cell Discov. 2017 Oct 6;8(52):90215-90224
Huang X, Yan Y, Tu Y, Gatti J, Broze GJ Jr, *Zhou A., *Olson ST. Structural basis for catalytic activation of protein Z-dependent protease inhibitor (ZPI) by protein Z. Blood. 2012 Aug 23;120(8):1726-33.
*Zhou A. *Carrell R.W; Murphy M.P. Wei Z; Yan Y; Stanley P. L D; Stein P.E; Broughton P.F; Read R J. A redox switch in angiotensinogen modulates angiotensin release. Nature 2010; 468(7320):108-11.
Wei Z, Yan Y, Carrell RW, *Zhou A. Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X. Blood. 2009 Oct 22; 114(17): 3662-7.
*Zhou A, Wei Z, Read RJ, *Carrell RW. Structural mechanism for the carriage and release of thyroxine in the blood. Proc Natl Acad Sci U S A. 2006, 103(36):13321-6.
Mushunje A, Evans G, Brennan SO, Carrell RW, *Zhou A. Latent antithrombin and its detection, formation and turnover in the circulation. J. Thromb. Haemost. 2004 Dec; 2(12): 2170-