Research Field: Bacterial infections and host innate immunity
Yue Xu, Ph.D., has been a principal investigator in the Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine since 2021. She graduated from the College of Biology, China Agricultural University in 2012 with a B.S. degree. After receiving her Ph.D. degree from the National Institute of Biological Science, Beijing (NIBS) in 2019, she continued her research on pathogen infection and xenophagy at NIBS as a postdoctoral scientist. Dr. Xu's research group mainly focuses on pathogenic bacterial infections and host innate immune defense mechanisms. Representative works were published in Cell, Nature Structural & Molecular Biology, Autophagy, mBio, etc. Dr. Xu has been selected for the China Association for Science and Technology's Young Talent Support Project, been elected as the Shanghai Youth Science and Technology Rising Star, and been honored with the WuXi AppTec Life Chemistry Research Scholar Award.
Liu, Y., Zeng, H., Hou, Y., Li, Z., Li, L., Song, X., Ding, J., Shao, F., Xu, Y. (2022). Calmodulin Binding Activates Chromobacterium CopC Effector to ADP-Riboxanate Host Apoptotic Caspases. mBio, e00690-22
Xu, Y., Ding, J. (2022). Endomembrane damage sensing by V-ATPase recruits ATG16L1 for LC3 lipidation in situ. Autophagy, 1-3
Xu, Y., Cheng, S., Zeng, H., Zhou, P., Ma, Y., Li, L., Liu, X., Shao, F., Ding, J. (2022). ARF GTPases activate Salmonella effector SopF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy. Nature Structural & Molecular Biology 29 (1), 67-77
Li, Z., Liu, W., Fu, J., Cheng, S., Xu Y., Wang, Z., Liu, X., Shi, X., Liu, Y., Qi X., Liu, X., Ding, J., Shao, F. (2021) Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11. Nature 599 (7884), 290-295
Schubert, K.A., Xu, Y., Shao, F., and Auerbuch, V. (2020). The Yersinia type III secretion system as a tool for studying cytosolic innate immune surveillance. Annual review of microbiology 74:221-245
Xu, Y., Zhou, P., Cheng, S., Lu, Q., Nowak, K., Hopp, A.K., Li, L., Shi, X., Zhou, Z., Gao, W., Li, D., He, H., Liu, X., Ding, J., Hottiger, M. O., Shao, F. (2019). A bacterial effector reveals the V-ATPase-ATG16L1 axis that initiates xenophagy. Cell 178, 552-566 e520.
Zhou, P., She, Y., Dong, N., Li, P., He, H., Borio, A., Wu, Q., Lu, S., Ding, X., Cao, Y., Xu, Y., Gao, W., Dong, M., Ding, J., Wang, D. C., Zamyatina, A., Shao, F. (2018). Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose. Nature 561, 122-126.
Liu, W.*, Zhou, Y.*, Peng, T.*, Zhou, P., Ding, X., Li, Z., Zhong, H., Xu, Y., Chen, S., Hang, H.C., Shao, F. (2018). Nε-fatty acylation of multiple membrane-associated proteins by Shigella IcsB effector to modulate host function. Nature microbiology 3, 996-1009.
Lu, Q., Xu, Y., Yao, Q., Niu, M., and Shao, F. (2015). A polar-localized iron-binding protein determines the polar targeting of Burkholderia BimA autotransporter and actin tail formation. Cellular microbiology 17, 408-424.
Lu, Q.*, Yao, Q.*, Xu, Y.*, Li, L., Li, S., Liu, Y., Gao, W., Niu, M., Sharon, M., Ben-Nissan, G., Zamyatina, A., Liu, X., Chen, S., Shao, F. (2014). An iron-containing dodecameric heptosyltransferase family modifies bacterial autotransporters in pathogenesis. Cell host & microbe 16, 351-363. (* co-first author)
Yao, Q. *, Lu, Q. *, Wan, X., Song, F., Xu, Y., Hu, M., Zamyatina, A., Liu, X., Huang, N., Zhu, P., Shao, F. (2014). A structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family. eLife 3.