College of Basic Medical Sciences

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SHEN Shaoming

Email: smshen@shsmu.edu.cn

Tel: 63846590

Research Field: Aberrant Protein Modification and Processing in Cancer

Personal Introduction

Education:

  • 09/2006-07/2011, Ph.D., Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences, Shanghai, China

  • 10/2002-07/2006, B.S., College of Life Sciences, Zhejiang University, Hangzhou, China

Position:

  • 07/2011-, Faculty, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Publications

  • He P#, Zhang C#, Ji Y#, Ge MK, Yu Y, Zhang N, Yang S, Yu JX, Shen SM*, Chen GQ*. Epithelial cells-enriched lncRNA SNHG8 regulates chromatin condensation by binding to Histone H1s. Cell Death Differ. 2022 Feb 9.

  • He P#, Zhang C, Chen GQ, Shen SM*. Loss of lncRNA SNHG8 promotes epithelial-mesenchymal transition by destabilizing CDH1 mRNA. Sci China Life Sci. 2021 Nov;64(11):1858-1867.

  • Ge MK#, Zhang N#, Xia L#, Zhang C, Dong SS, Li ZM, Ji Y, Zheng MH, Sun J, Chen GQ*, Shen SM*. FBXO22 degrades nuclear PTEN to promote tumorigenesis. Nat Commun. 2020 Apr;11:1720

  • Shen SM#*, Zhang C#, Ge MK#, Dong SS#, Xia L, He P, Zhang N, Ji Y, Yang S, Yu Y, Zheng JK, Yu JX, Xia Q, Chen GQ*. PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation. Nat Cell Biol. 2019 Nov;21(11):1436-1448

  • Shen SM#*, Ji Y#, Zhang C, Dong SS, Yang S, Xiong Z, Ge MK, Yu Y, Xia L, Guo M, Cheng JK, Liu JL, Yu JX, Chen GQ*. Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role. Nat Commun. 2018 Jun 19;9(1):2392

  • Xiong Z#, Guo M#, Yu Y, Zhang FF, Ge MK, Chen GQ*, Shen SM*. Downregulation of AIF by HIF-1 contributes to hypoxia-induced epithelial-mesenchymal transition of colon cancer. Carcinogenesis. 2016 Nov 1;37(11):1079-1088

  • Shen SM#, Guo M#, Xiong Z, Yu Y, Zhao XY, Zhang FF, Chen GQ*. AIF inhibits tumor metastasis by protecting PTEN from oxidation. EMBO Rep. 2015 Nov;16(11):1563-80