College of Basic Medical Sciences

16F75

WANG Xu

Email: xu.wang@shsmu.edu.cn

Tel: 021-63846590-776417

Research Field: Ultrasensitive detection of biomarkers

Personal Introduction

Work Experience

  • 2021/06-present, Professor, Department of Pathology, Shanghai Jiao Tong University School of Medicine

  • 2017/07-2021/05, Research Fellow, Brigham and Women’s Hospital at Harvard Medical School, and Wyss Institute at Harvard University, United States

  • 2016/06-2017/06, Postdoc, Analytical Chemistry, Tufts University, United States

Education Background

  • 2012/10-2016/03, Ph.D. Analytical Chemistry, Technical University of Munich, Germany

  • 2009/09-2012/07, M. Eng., Chemical Engineering and Technology, Dalian University of Technology

  • 2005/09-2009/07, B. Eng., Chemical Engineering and Technology, Dalian University of Technology

Scientific Research Projects

The Wang Lab works on the development of ultrasensitive methods for the detection of proteins, enzymes, nucleic acids and small molecules based on single-molecule technology. The established methods are used for the diagnosis of many diseases including cancers, infectious diseases, and neurodegenerative diseases.

Publications

  • Xu Wang, Alana F. Ogata and David R. Walt. Ultrasensitive Detection of Enzymatic Activity Using Single Molecule Arrays. J. Am. Chem. Soc. 2020, 142, 15098–15106.

  • Xu Wang and David R. Walt. Simultaneous Detection of Small Molecules, Proteins and microRNAs Using Single Molecule Arrays. Chem. Sci. 2020, 11, 7896-7903.

  • Xu Wang, Limor Cohen, Jun Wang and David R. Walt. Competitive Immunoassays for the Detection of Small Molecules Using Single Molecule Arrays. J. Am. Chem. Soc. 2018, 140, 18132-18139.

  • Xu Wang, Feng Li and Yirong Guo. Recent Trends in Nanomaterial-Based Biosensors for Point-of-Care Testing. Front. Chem. 2020, DOI: 10.3389/fchem.2020.586702.

  • Xu Wang, Reinhard Niessner, Dianping Tang and Dietmar Knopp*. Nanoparticle-Based Immunosensors and Immunoassays for Aflatoxins. Analytica Chimica Acta, 2016, 912, 10-23.

  • Xu Wang, Fengling Song,* and Xiaojun Peng. A Versatile Fluorescent Probe for Imaging Viscosity and Hypochlorite in Living Cells. Dyes and Pigments, 2016, 125, 89-94.

  • Xu Wang, Jutta Pauli, Reinhard Niessner, Ute Resch-Genger and Dietmar Knopp*. Gold Nanoparticle-Catalyzed Uranine Reduction for Signal Amplification in Fluorescent Assays for Melamine and Aflatoxin B1. Analyst, 2015, 140, 7305-7312.

  • Xu Wang, Reinhard Niessner and Dietmar Knopp*. Controlled Growth of Immunogold for Amplified Optical Detection of Aflatoxin B1. Analyst, 2015, 140, 1453-1458.

  • Xu Wang, Reinhard Niessner and Dietmar Knopp*. Magnetic Bead-Based Colorimetric Immunoassay for Aflatoxin B1 Using Gold Nanoparticles. Sensors, 2014, 14, 21535-21548.

Patent

  • Methods of Detecting and Measuring Enzymatic Activity. Patent # PCT 63/062,030.

  • Methods and Compositions for Detection and Quantification of Small Molecules and Other Analytes. Patent # WO2020036906.