Research interests:

1.Alternative test in toxicology

• a)Stem cell toxicology and developmental toxicology

• b)Stem cell-derived organoids and their application in toxicity testing

• c)Predictive toxicology

2.Emerging pollutants and their toxic mechanisms in target organs

• a)Cardiotoxicity

• b)Hepatotoxicity

• c)Osteotoxicity

Educational background

• 2014.09-2017.06

   Shanghai Jiao Tong University, PhD in Public health and predictive medicine

Professional Experience:

• 2020.07-present

   Assistant researcher, Shanghai Jiao Tong University, School of medicine

• 2017.10-2020.06

   Postdoctoral fellow, Shanghai Jiao Tong University, School of medicine

Research projects

• 2022-2025    Foundation of Shanghai Science and Technology Committee (Specific Program for animal welfare and alternative testing), PI

• 2020-2023   University Startup Fund, PI

• 2018-2020   China postdoctoral science foundation, PI

• 2019-2021   Foundation of Shanghai Science and Technology Committee (Specific Program for animal welfare and alternative testing), participating

• 2016-2019   National Natural Science Foundation of China, participating

Other professional activities

• Reviewer for Theranostics, Environment International, Ecotoxicology and Environmental Safety, Toxicology.

Selected Publications

• Xie Y, Li Y, Feng Y, Cheng W*, Wang Y*. Inhalable microplastics prevails in air: exploring the size detection limit. Environ Int, 2022, 162:107151.

• Cheng W*, Li X, Zhou Y, Yu H, Xie Y, Wang H, Li Y, Feng Y, Wang Y*. Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids. Sci Total Environ, 2022, 806 (Pt 1): 150328.

• Cheng W#, Li X#, Yang S, Wang H, Li Y, Feng Y, Wang Y*. Low doses of BPF-induced hypertrophy in cardiomyocytes derived from human embryonic stem cells via disrupting the mitochondrial fission upon the interaction between ERβ and calcineurin A-DRP1 signaling pathway. Cell Biol Toxicol, 2021, doi:10.1007/ s10565-021-09615-y.

• Cheng W, Yang S, Li X, Liang F, Zhou R, Wang H, Feng Y, Wang Y*. Low doses of BPA induced abnormal mitochondrial fission and hypertrophy in human embryonic stem cell-derived cardiomyocytes via the calcineurin-DRP1 signaling pathway: A comparison between XX and XY cardiomyocytes. Toxicol Appl Pharmacol.2020, 388:114850.

• Cheng W, Yang S, Liang F, Zhou R, Li Y, Feng Y, Wang Y*. Low-dose exposure to triclosan disrupted osteogenic differentiation of mouse embryonic stem cells via BMP/ERK/Smad/Runx-2 signalling pathway. Food Chem Toxicol. 2019, 127:1-10.

• Cheng W, Zhou R, Liang F, Wei H, Feng Y, Wang Y*. Application of mouse embryonic stem cell test to detect gender-specific effect of chemicals: a supplementary tool for embryotoxicity prediction. Chem Res Toxicol. 2016,29(9):1519-1533.

• Cheng W, Zhou R, Feng Y*, Wang Y*. Mainstream smoke and sidestream smoke affect the cardiac differentiation of mouse embryonic stem cells discriminately. Toxicology. 2016, 357:1-10.

• Cheng W, Yu Z, Feng L, Wang Y*. Perfluorooctane sulfonate (PFOS) induced embryotoxicity and disruption of cardiogenesis. Toxicol In Vitro. 2013,27(5):1503-1512.

• Li X, Cheng W*, Yang S, Liang F, Wang H, Feng Y, Wang Y*. Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett, 2022, 355:1-18.

• Wang L#, Cheng W#, Zhu J#, Li W*, Li D, Fu Q, Mo X, Yang X, Zhao W, Ren M, Ren J, Zhang K*. Electrospun nanoyarn and exosomes of adipose-derived stem cells for urethral regeneration: evaluations in vitro and in vivo. Colloids Surf B Biointerfaces, 2022, 209: 112218.

• Zhou R, Cheng W, Feng Y, Wang W, Liang F, F Luo, Yang S, Wang Y*. Combined effects of BPA and PFOS on fetal cardiac development: In vitro and in vivo experiments. Environ Toxicol Pharmacol, 2020, 80: 103434.

• Yang S, Cheng W, Li X, Liang F, Zhou R, Wang H, Feng Y, Wang Y*. Use of embryonic stem cell-derived cardiomyocytes to study cardiotoxicity of bisphenol AF via the GPER/CAM/ eNOS pathway.Toxicology, 2020,432:152380.

• Zhou R, Cheng W, Wei H, Liang F, Feng Y, Wang Y*. Interactions between three typical endocrine-disrupting chemicals (EDCs) in binary mixtures exposure on myocardial differentiation of mouse embryonic stem cell. Chemosphere. 2017, 178: 378-383.