School of Public Health

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WANG Xianli

Associate Professor

Department of Food Safety and Toxicology

Address: Room 709, Teaching and Research Building

E-mail:wangxianli@shsmu.edu.cn

Bio

  • WANG Xianli graduated from Ocean University of China in 2009 and majored in cell Biology.  For many years, she has been engaged in the regulation of genomic stability of adult neural stem cells on aging and the regulation of neural diversity by the genomic stability of neural stem cells during neural development.  She has presided over 9 projects including the National Natural Science Foundation of China youth Project, published more than 20 SCI indexed articels, participated in the compilation of one thesis, and authorized 2 invention patents.

Professional Experience

  • Dingka Song; Junchen Meng; Jie Cheng; Zheng Fan; Pengyu Chen; Hefei Ruan; Zhongyuan Tu; Ning Kang; Nan Li; Ying Xu; Xiaobo Wang; Fei Shu; Libing Mu; Tengfei Li; Wenran Ren; Xin Lin; Jun Zhu; Xiaohong Fang; Matthias W. Amrein; Weihui Wu; Li-Tang Yan; Junhong Lü; Tie Xia; Yan Shi ; Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution, NATURE MICROBIOLOGY, 2019, 4(1): 97-111

  • GUO DongXing; SHI XuanLing; SONG DingKa; ZHANG LinQi ; Persistence of VRC01-resistant HIV-1 during antiretroviral therapy, SCIENCE CHINA-LIFE SCIENCES, 2014, 57(1): 88-96

  • Dongxing Guo; Xuanling Shi; Kelly C. Arledge; Dingka Song; Liwei Jiang; Lili Fu; Xinqi Gong; Senyan Zhang; Xinquan Wang; Linqi Zhang ; A Single Residue within the V5 Region of HIV-1 Envelope Facilitates Viral Escape from the Broadly Neutralizing Monoclonal Antibody VRC01, JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287(51): 43170-43179

Research Interests

  • Role of Stem cells Response to Obesity in Regulating Chronic Diseases

  • Stem Cell Responses to DNA Damage during Aging

  • Role of Stem Cells in Tumorigenesis and Development

Research Projects

  • National Natural Science Foundation of China (2016.01-2018.12)

  • The 51st China Postdoctoral Science Foundation (2012.06-2013.09)

  • Postdoctoral Research Funding Program of Shanghai (2012.09-2013.09)

  • Excellent Young Talents Training Program of Shanghai Health System (2014.01-2016.12)

  • Excellent Talent Training Program of Tongji University (2011.12-2013.09)

  • Postdoctoral Innovation Project of Shandong Province, The first prize (2011.03-2013.03)

  • Scientific Research Award Fund for Outstanding Young and Middle-aged Scientists of Shandong Province (2011.02-2013.12)

  • The 48th China Postdoctoral Science Foundation (2010.03-2011.08)

Publications

  • J Ren #, XL Wang #, CM Dong #, GM Wang #, WJ Zhang, CH Cai, MQ Qian, DJ Yang, B Ling, K Ning, ZY Mao, BH Liu, TH Wang, LL Xiong, WY Wang, AB Liang, ZL Gao, J Xu. Sirt1 protects neural stem cells from DNA double strand breaks and attenuates olfactory memory decline during aging in mice. Stem Cells,2022, https://academic.oup.com/stmcls/advance-article/doi/10.1093/stmcls/sxac008 /6535124.

  • CM Dong #, XL Wang #, GM Wang #, LX Sun #, L Zhu, DJ Yang, S Gao, WJ hang, B Ling, AB Liang, ZL Gao, J Xu. ATM modulates subventricular zone neural stem cell maintenance and senescence through Notch signaling pathway. Stem Cell Res,58 (2022)102618, https://doi.org /10. 1016/j.scr.2021.102618.

  • XL Wang, CX Sun, L Zhu, LX Sun, RJ Ma, ZG Wang, B Lu, X Chen, J Xu. Quantitative proteomic analysis revealed changes in protein synthesis and mitochondrial functions after acute DNA damage in mouse neural stem cells. Neuro Lett, 2017,653: 355-361.

  • XL Wang, CM Dong, lX sun, L Zhu, CX Sun, RJ Ma, k Ning, JF Zhang, B Lu, J Xu. Quantitative proteomic analysis of age-related subventricular zone proteins associated with neurodegenerative disease. Sci Rep,2016,6,37443;doi:10.1038/ srep37443.

  • CM Dong #, XL Wang #, GM Wang, WJ Zhang, L Zhu, S Gao, DJ Yang, Y Qin, QJ Liang, YL Chen, HT Deng, K Ning, AB Liang, ZL Gao, J Xu. A stress induced cellular aging model with postnatal neural stem cells. Cell Death Dis,2014 Mar 13;5:e1116. doi: 10.1038/cddis.2014.82.

  • DJ Yang #, XL Wang #, A Ismail, CJ Ashman, CF Valori, GM Wang, SE Gao, A Higginbottom, PG Ince, M Azzouz, J Xu, PJ Shaw, K Ning. PTEN regulates AMPA receptor-mediated cell viability in iPS-derived motor neurons. Cell Death Dis,2014 Feb 27;5:e1096. doi:10.1038/cddis.2014.55.

  • N Wang #, XL Wang #, CG Yang, XJ Zhao, YX Zhang, TZ Wang, SL Chen. Molecular cloning and multifunctional characterization of GRIM-19 homologue from turbot. Dev Comp Immunol,2014,43(1):96-105.

  • CG Yang #, XL Wang #, J Tian, W Liu, F Wu, M Jiang, H Wen. Evaluation of reference genes for quantitative real-time RT-PCR analysis of gene expression in Nile tilapia. Gene,2013,527:183-192.

  • N Wang #, XL Wang #, CG Yang, SL Chen. Molecular cloning, subcelluar location and expression profile of signal transducer and activator of transcription 2 (STAT2) from turbot. Fish Shellfish Immun,2013,35:1200-1208.

  • XL Wang, YX Zhang, CG Yang, SL Chen. Cloning, characterization and expression analysis of Y-Box family members YB-1 in turbot. Fish Shellfish Immun,2012, 33(5): 1215-1221.

  • B Zhang #, XL Wang #, SL Chen. Establishment and characterization of a testicula r cell line from half smooth tongue sole. Int J Bio Sci,2011,7(4):452-459.

  • XL Wang, N Wang, ZX Sha, SL Chen. Establishment, characterization of a new cell line from heart of half smooth tongue sole. Fish Physiol Biochem,2010,36: 1181- 1189.

  • N Wang #, XL Wang #, ZX Sha, YS Tian, SL Chen. Development and characterization of a new marine fish cell line from turbot. Fish Physiol Biochem, 2010,36(4):1227-1234.

  • XL Wang, N Wang, ZX Sha, SL Chen. Establishment, characterization, and virus susceptibility of a new marine cell line from spotted halibut. J Ocean U China, 2010,9(2): 162-168.

  • ZX Sha #, GC Ren #, XL Wang #, N Wang, SL Chen. Development and characterization of a cell line from the embryos of half smooth tongue sole. Acta Oceanol Sin,2010,29(2):81-87.

  • SE Gao, P Zhao, C Lin, YX Sun, YL Wang, ZC Zhou, DJ Yang, XL Wang, HZ Xu, F Zhou, LM Cao, W Zhou, K Ning, X Chen, J Xu. Differentiation of human adipose-derived stem cells into neuron-like cells which are compatible with photocurable three- dimensional scaffolds. Tissue Eng:Part A,2014,DOI: 10.1089/ten.tea.2012.0773.

  • YP Jin, JY Wang, HC Li, SE Gao, RF Shi, DJ Yang, XL Wang, L Zhu, XJ Wang, CW Chen, K Ning, QC Fu, J Xu, ZL Gao. Extracellular vesicles secreted by human adipose -derived stem cells hASCs improve survival rate of rats with acute liver failure by releasing lncRNA H19. EBioMedicine,2018,34:231-242.

  • CG Yang, XL Wang, L Wang, B Zhang, SL Chen. A new Akirin1 gene in turbot: molecular cloning, characterization and expression analysis in response to bacterial and viral immunological challenge. Fish Shellfish Immun,2011,30: 1031-1041.

  • CG Yang, SS Liu, Bing Sun, XL Wang, N Wang, SL Chen. Iron-metabolic function and potential antibacterial role of Hepcidin and its correlated genes (Ferroportin 1 and Transferrin Receptor) in turbot. Fish Shellfish Immun,2013,34:744-755.

  • N Wang, CG Yang, ZZ Sun, XL Wang, SL Chen. Signal transducer and activator of transcription 3 (STAT3) homologue in turbot: molecular characterization and expression analysis. Fish Shellfish Immun,2011,30(1):255-262.