The Shanghai Key Laboratory of Diabetes Mellitus is set in the Shanghai Jiao Tong University Affiliated Sixth People's Hospital, which is one of the earliest laboratories focusing on basic and clinical researches on diabetes in China. It is the birthplace of research on molecular etiology of diabetes in China, with most and abundant research achievements of diabetes nationwide. The area of the laboratory currently reaches 8000m2.Under the leadership of Prof. Kunsan Xiang and Prof. Weiping Jia, renowned diabetologists and academicians of the Chinese Academy of Engineering in China, the key laboratory has made a series of achievements in terms of the researches on etiology, pathogenesis, diagnosis, treatment and prevention of diabetes, obesity and metabolic syndrome, which has reached the advanced level internationally and the leading level nationwide.Academic talents receive the awards of the Outstanding Youth of the National Foundation of China, the Young Scholars of the Yangtze River, the Leading Talents of Shanghai, the Outstanding Academic Leaders of Shanghai, the Pujiang Talent Program, the Rising Star Program, the “Sailing Program” of Young Science and Technology Talents, the Shanghai Chenguang Scholars Program, etc. In total, there are 18 doctoral supervisors.The laboratory is positioned as an applied basic research laboratory, with focus on population research, including epidemiology, pathogenesis, and clinical translational researches of diabetes among Chinese. Its goal is to develop an international-level scientific and translational research base. It has a great impact on epidemiology, genetics and pathogenesis study, development of the new technologies of diagnosis and treatment, translational medicine, and artificial intelligence use in the research area of diabetes. Relevant research results have been published in the journals of BMJ, Cell, Cell Metabolism, Nature biotechnology, Nature communication, Science translational medicine, Lancet Diabetes Endocrinology, Diabetes, etc. There are more than 1,000 papers published in international journals and 36 awards based on the achievements from this laboratory, including 5 national science and technology progress awards and 5 provincial or ministry-level science and technology progress awards. Lead the development of six national guidelines related to diabetes prevention and treatment, and participate in the development of two international guidelines.