Shanghai Key Laboratory of Orthopaedic Implants is affiliated to the Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine. Founded by Prof. Ke-rong Dai in 1986, the lab initially focused on biomechanical researches. In 2003, the lab was renamed as bone and joint research center of Shanghai Second Medical University. In 2008, the lab was enlisted in Shanghai key laboratory construction plan. With the rapid development during the past decades, the lab has gradually become an influential orthopedic research center and R&D center. Headed by Academician Ke-rong Dai, Prof. Ting-ting Tang and Prof. Jie Zhao, the lab owns an academic research team comprised of orthopedic surgeons, researchers, engineers and technicians, featuring its cross-disciplinary research in medicine and engineering. At present, the lab has formed the organizational structure of “one body & two wings”. The main “body” of the lab, located in Pudong Scientific and Education Park of Shanghai Ninth People’s Hospital, focuses on biomechanics, biomaterials, regenerative medicine, degenerative diseases and bone tumors. One “wing” is the Engineering Research Center of Digital Medicine and Clinical Translation, Ministry of Education, which mainly carries out researches on implant-related key problems, digital medicine and serves as the pre-production and industrial base of orthopedic implants. The other “wing” is the Medical 3D Printing Innovation Research Center, which mainly focuses on personalized 3D printed products and clinical translation.The lab has active collaborations with first-class research institutes and scientists home and abroad. Established collaborating centers include the Sino-French Research Laboratory of Biomaterials and Cell Therapy, the Collaborating Orthopedic Translating Research Center with ICMRS (International Chinese Musculoskeletal Research Society, ICMRS). In addition, the lab is responsible for editing Journal of Medical Biomechanics and Journal of Orthopeadic Translation.